s40813-025-00420-1

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© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y / 4 . 0 / . The Creative Commons Public Domain Dedication waiver ( h t t p : / / c r e a t i v e c o m m o n s . o r g / p u b l i c d o m a i n / z e r o / 1 . 0 / ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Kschonek et al. Porcine Health Management (2025) 11:13 https://doi.org/10.1186/s40813-025-00420-1 Porcine Health Management *Correspondence: Julia Kschonek julia.dorothee.kschonek@tiho-hannover.de 1 Institute for Biometry, Epidemiology and Information Processing (IBEI), University of Veterinary Medicine, Foundation, Bünteweg 2, 30559 Hannover, Germany 2 Field Station for Epidemiology, University of Veterinary Medicine, Foundation, Büscheler Str. 9, 49456 Hannover, Bakum, Germany 3 Institute for Animal Hygiene, Animal Welfare and Farm Animal Behavior, University of Veterinary Medicine, Foundation, Bischofsholer

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, Bakum, Germany 3 Institute for Animal Hygiene, Animal Welfare and Farm Animal Behavior, University of Veterinary Medicine, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany 4 Clinic for Horses, University of Veterinary Medicine, Foundation, Bünteweg 9, 30559 Hannover, Germany 5 Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University Leipzig, An Den Tierkliniken 39, 04103 Leipzig, Germany 6 Clinic for Small Animals, University of Veterinary Medicine, Foundation, Bünteweg 2, 30559 Hannover, Germany 7 Clinic for Swine and Small Ruminants, Forensic Medicine and Ambulatory Service, University of Veterinary Medicine, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany Abstract Background Pain in pigs needs to be managed and treated to the bene t of individual pigs. It is imperative for veterinarians and farmers to assure that pigs do not su er from unnecessary pain that can be relieved. This review focusses on pain related to spontaneously occurring diseases and injuries since this topic is often neglected. The aim is to identify ways to accelerate knowledge and evidence in this area to prevent painful conditions in pigs in the future. Methods A scoping review was conducted with results from a search of the electronic databases VetSearch and CABI Rxiv. The ndings of selected publications are narratively synthesized and reported orienting on the PRISMA ScR guideline. Results The results emphasize that pigs experience pain due to spontaneously occurring diseases and injuries, but systematic knowledge about this topic is scarce. More research is especially needed for rare diseases (such as UTIs). Moreover, research conducted about the topic pain in pigs should involve standardized protocols to document, analyse and

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rare diseases (such as UTIs). Moreover, research conducted about the topic pain in pigs should involve standardized protocols to document, analyse and share results on pain detection beyond a projects timeframe. The ndings of this review suggest that such a protocol would comprise validated pain identi cation measures over time and in relation to administered pain treatment. Conclusion The results of this study invite veterinary practitioners to reconsider in each pig patient whether pain and related indicators are present, how to handle the situation and document the process to ensure the welfare of individual compromised pigs. Keywords Pigs, Pain, Assessment, Spontaneously occurring diseases and injuries Part II: understanding pain in pigs—pain assessment in pigs with spontaneously occurring diseases or injuries Julia Kschonek 1* , Kathrin Deters 2 , Moana Miller 3 , Jennifer Reinmold 2 , Lara Twele 4 , Ilka Emmerich 5 , Sabine Kästner 6 , Nicole Kemper 3 , Lothar Kreienbrock 1 , Isabel Hennig-Pauka 2 , Michael Wendt 7 and Elisabeth grosse Beilage 2

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Page 2 of 17 Introduction Pain in pigs can be induced by spontaneously occurring diseases and injuries as well as by damaging manage - ment procedures. In the literature, the focus to elaborate on signs of pain, pain mechanisms and therapy of pigs is often put on the latter topic and neglects common dis - eases such as pain due to gastric ulcer, claw avulsion or respiratory disorders. Irrespective of the reason for pain sensitation in pigs, pain-related conditions need to be carefully examined and treated by veterinarians and farmers. For this means, thorough knowledge is needed to examine, assess and therapize related conditions prop - erly. In a previous article, - part I - understanding pain in pigs [ 1 ], a narrative synthesis of common and latest pub - lished literature was generated for gathering basic knowl - edge in this respect. e former manuscript also provides an overview of dosages and administration of analgesic agents. is subsequent article - part II - focusses more specifically on pain induced by spontaneously occurring diseases and injuries. is scoping review summarizes how pain in specific diseases is addressed in theory and in veterinary practice. Not anticipating the discussion of results, it will be shown that even for common diseases like lameness in pigs, descriptions of the assessment and alleviation of pain are often indirect or vague. Hence, this review will help readers to learn about the current state of pain relief approaches and findings, and thus what is needed to accelerate evidence about pain in spontane - ously occurring diseases and injuries in the future. Method e review was conducted in accordance with the PRISMA-ScR guideline [ 2 ] which is dedicated to organize the report of scoping reviews. In contrast to systematic reviews

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cted in accordance with the PRISMA-ScR guideline [ 2 ] which is dedicated to organize the report of scoping reviews. In contrast to systematic reviews that answer one particular question with the help of specific results and evidence, a scoping review aims to answer generic questions and to provide an initial and structured overview of findings in the field [ 2 , 3 ]. e research question to be answered in this study is: what is known about the identification and evaluation of pain in pigs with spontaneously occurring diseases or inju - ries? For this review, pain is defined as [a]n unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tis - sue damage [ ] ([ 4 ], Text Box 2). Depending on its neu - roanatomical origin, pain can result from the activation of nociceptors (nociceptive pain), which are among the cardinal symptoms of inflammation (inflammatory pain), lesions of neural tissue (neuropathic pain) and combina - tions of these conditions [ 1 ]. Following this definition, a review protocol was predefined and discussed by the author group (experts in porcine health management, pain, anaesthesia, pharmacology and research method - ology in veterinary medicine). e discussion concerned the quality and comprehensibility of the eligibility crite - ria for the selected papers, the search mode, the database and the review documentation. For the search of latest publications, the databases VetSearch and CABI search Rxiv were used to identify papers matching the terms for animals (pigs), the focus of this article (pain) and terms for specific diseases or inju - ries ( topics ). Many terms were defined, and specifications were established during the search. To enable readers to follow the

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cific diseases or inju - ries ( topics ). Many terms were defined, and specifications were established during the search. To enable readers to follow the process for each topic of the manuscript, the metrics used herein are outlined in the supplementary material (Additional file S1 ). Papers were included if accessible and peer reviewed or books (chapters) published between 2015 and end of March 2023 besides standard literature on pig diseases and work found through snowballing technique. Included languages are English and German. Concerning the topic, papers are included if they elaborate on the search terms in more than one sentence (buzz-words), i.e. contribute to the topic with descriptive or detailed insight. Pain induced by spontaneously occurring diseases or injuries in pigs Locomotor diseases Locomotor diseases include a wide range of infectious, non-infectious or degenerative diseases and injuries, including purulent or non-purulent arthritis, osteoar - thritis, osteochondrosis, fractures, tenosynovitis, con - tusions, muscle tearing, dewclaw injuries or fractures, and coronary band and other foot lesions [ 5 , 6 ]. Abnor - malities in the locomotor system often lead to lameness, which manifests as reduced weight bearing on at least one leg, an inability to stand up in the hindquarters (hind leg weakness) or sitting or lying posture. Lame animals exhibit an abnormal gait, characterised by asymmetrical weight distribution, steep walking, increased stride fre - quency, shortened stride lengths and/or an arching of the spine. Some animals also exhibit rapid changes between loading and unloading of a limb (tapping) [ 7 , 8 ]. Lameness in pigs often manifests as changes in behav - iour. Lame pigs reduce their activity and exploratory behaviour and reduce their

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ng) [ 7 , 8 ]. Lameness in pigs often manifests as changes in behav - iour. Lame pigs reduce their activity and exploratory behaviour and reduce their interactions with pen mates. It has also been observed that lame sows lie down on walls more often than their non-lame counterparts [ 9 11 ]. Sows with artificially induced arthritis showed lon - ger periods of lying down and shorter periods of standing up [ 11 15 ]. Overgrowth of claws in sows leads to shorter stance phases and feed intake times [ 16 ]. Due to lameness and associated pain, behaviour changes; affected pigs eat and drink less or not at all, as their condition does not allow them to compete with non-lame pigs for feed and water [ 27 ]. Lame sows consume significantly less water than healthy sows [ 17 ]. is increases the risk of lame animals not being able to fulfil their needs sufficiently

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Page 3 of 17 and suffer from hunger and thirst [ 10 , 18 ]. erefore, lame sows should be housed in hospital pens where they can recover and not have to compete with healthy sows for water and feed. A feed reward study revealed that moderately to severely lame sows received fewer rewards than mildly lame and non-lame sows [ 18 ]. Lameness and associated expenses have a signifi - cant economic impact. Lame animals require additional labour, from identification to treatment, which implies higher veterinary costs. Lameness in sows can also have a negative impact on reproductive performance [ 12 , 19 ]. On average, sows that leave the herd due to lameness are younger than those that are removed for other rea - sons [ 20 ]. Lame sows are less efficient at breeding and are more likely to be culled due to lameness [ 10 , 21 ]. Muscu - loskeletal problems are a leading cause of culling in pig herds [ 22 , 23 ]. Lameness serves as a key indicator for animal welfare assessment in pig farming [ 24 ]. Lameness is usually easy to recognize and is a clear sign of pain [ 12 , 24 , 25 ]. e observed behavioural changes in movement disorders are most likely caused by limited mobility, pain or dis - comfort and sickness behaviour [ 10 ]. Lameness is rated as extremely painful by farmers and veterinarians, espe - cially when there is minimal weight bearing [ 26 ]. In the same survey, farmers stated that recognizing pain in pigs was difficult and that they were unsure how to address it. However, the assessment of pain is often subjective and, therefore, difficult to quantify [ 10 ]. Lameness can cause both pain and stress. Stress is associated with changes in the immune system and increases the susceptibility of animals to other diseases. If lameness persists, additional diseases can

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ociated with changes in the immune system and increases the susceptibility of animals to other diseases. If lameness persists, additional diseases can develop and affect animal health beyond lameness [ 10 ]. In fattening pigs, fractures, osteochondro - sis dissecans and infectious arthritis are considered par - ticularly painful [ 23 ]. In addition to the visual observation of animals, tech - nology such as pressure mats, force plates, motion cap - ture systems and accelerometers can be used to record animal movement and limb loading [ 14 , 15 , 27 ]. e evaluation of these electronic systems enables the iden - tification of lameness [ 6 ]. Using an accelerometer, previ - ous studies showed that lame sows take more steps per minute than healthy animals [ 14 ]. Measurements with a force plate showed that lame sows have a lower contra - lateral hind leg load. Pressure mat analyses showed that lame animals have an asymmetrical gait, probably due to the relief of the affected limb to reduce pain [ 11 , 28 ]. One advantage of electronic detection systems is their objec - tivity. Visual observations are subjective and have high variability in reproducibility depending on the training and experience of the observer. However, visual obser - vations are inexpensive and easy to integrate into daily work routines [ 29 ]. Foot and joint problems were cited by farmers as the most common reason for administering NSAIDs [ 30 ]. In countries where opioid analgesics are licenced, buprenor - phine can be used to reduce gait asymmetry, while the NSAID meloxicam can be used to reduce stride fre - quency, thus leading to better symmetry of hind leg movement in pigs with spontaneously occurring lame - ness [ 6 , 11 , 14 ]. In non-infectious locomotor disorders in fattening pigs, gilts

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of hind leg movement in pigs with spontaneously occurring lame - ness [ 6 , 11 , 14 ]. In non-infectious locomotor disorders in fattening pigs, gilts and sows, an improved lameness score was observed 24 h after treatment with meloxi - cam during gait and at rest [ 31 ]. After inducing lame - ness, meloxicam and flunixin led to improved leg loading and movement in sows [ 32 ]. Moreover, the severity of lameness decreased, but one week after the induction of lameness, it had disappeared [ 33 , 34 ]. Sows affected by spontaneously occurring lameness and treated with meloxicam had longer standing times after feeding than those in the control group [ 14 ]. Pain therapies are reported to normalize the behaviour of lame sows [ 25 ]. A survey revealed that, if lame pigs were treated, Metacam was usually selected as the medication, but only a quar - ter of the farmers initiated treatment [ 26 ]. Meloxicam was named the most popular painkiller according to this survey. Skin ulcers and decubitus symptoms Ulcer refers to an external skin trauma that mainly develops from top to bottom and may even affect under - lying bones [ 35 38 ]. In pigs, ulcers result from lying for a longer time in an unchanged posture, which compresses blood vessels supplying the skin and results in insufficient blood circulation, cell death, and necrosis [ 39 41 ]. is kind of ulcer is classified as a pressure ulcer or decubitus and mainly develops in areas of the body, where bones are hardly padded by muscles or subcutaneous fat and thus are compressed by a hard floor. In general, ulcer - ative skin lesions can develop in many regions, such as the limbs, tail, flank, udder, legs or ears [ 38 , 42 , 43 ]. Most attention, however, is directed to shoulder ulcers located above the tuber

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, such as the limbs, tail, flank, udder, legs or ears [ 38 , 42 , 43 ]. Most attention, however, is directed to shoulder ulcers located above the tuber spinae scapulae , often initiated by longer lying during farrowing [ 35 , 44 , 45 ]. Irrespective of the location, most of the papers selected for this review did not focus on pain due to (shoulder) ulcers (for an example, see [ 35 ]). Topics address develop - ing improved clinical detection scores [ 35 , 46 ], increasing knowledge about behavioural responses and risk fac - tors [ 44 , 47 ], or assessing prevention [ 44 ] and treatment options [ 48 , 49 ]. Moreover, a review of epidemiologic and forensic aspects [ 38 ] and knowledge about causes, pre - vention and treatment have been generated [ 39 ]. In view of these findings, it may not be surprising that a clear definition of pain and related processes [to be expected or assessed] is often missing. It can be inferred from previous studies that tissue damage and inflammatory

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Page 4 of 17 processes typical of ulcers are related to acute pain [ 35 , 38 , 50 , 51 ]. In this respect, one previous paper elabo - rated on acute phase proteins [haptoglobin and albumin, among others], which appear to develop in correspon - dence with bilateral shoulder ulcers [ 48 ]. On the other hand, chronic pain may occur given that neuromas can develop over time [ 35 , 51 ]. Moreover, many papers argue that ulcers are painful for pigs because they are analogous to decubitus in humans, which can also be highly painful [ 35 , 45 , 48 , 52 , 53 ]. To assess the effect of (shoulder) ulcers on pigs, observ - ers generated scores for lesions and/or for behavioural aspects. e scoring system used in these papers is not standardized but follows a similar pattern (for an over - view see [ 35 ]). According to the tissue involved, for example, lesions with a score of 1 affect only the epider - mis, while lesions with a score of 2 also affect the dermis. Lesions with a score of 3 affect all skin layers, including the subcutaneous tissue, and lesions with a score of 4 affect the entire skin and the underlying bone [ 35 , 40 ]. Pain is likely to occur even with superficial layers, so findings such as size, scab, and wall alterations should be staged with regard to a histopathological score to avoid underestimation of clinical signs [ 35 , 40 ]. Further clinical signs address the adaptation of behav - iour [ 54 ]. Results indicate that even sows with moderately sized shoulder ulcers [3 cm in diameter] exhibit changes in behaviour, such as reduced lying time, increased fre - quency of postural changes, increased standing and reduced nursing frequency [ 54 ]. is behaviour appears to be both a response to pain and a way to protect against an exacerbation of the lesion [

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and reduced nursing frequency [ 54 ]. is behaviour appears to be both a response to pain and a way to protect against an exacerbation of the lesion [ 48 ]. Another change in behaviour is increased rubbing against fixtures of the farrowing crate [ 54 ], which may even be invoked by pal - pation of the shoulder to discriminate the reactions of affected and non-affected sows [ 51 ]. Moreover, a corre - lation between pain-associated reactions after palpation of shoulder ulcers and the depth of the lesion has been proven [ 55 ]. Although the results speak in favour of pain sensa - tion in pigs due to shoulder ulcers, a study has recently outlined the question of whether (pain in) early stages of shoulder ulcers can be deduced from changes in rou - tine behaviours [ 47 ]. Indeed, behavioural changes corre - sponding to early tissue changes, such as skin reddening, might be subtle. Detection of subtle changes requires a dedicated study design (in terms of time points in rela - tion to farrowing (or previous ulcers), observation time, frequency, sample and effect size apart from a treatment- effect protocol). To the knowledge of the authors, no study elaborating on these points has been published thus far. In this regard, practitioners should carefully evaluate predisposed locations and consider providing pain relief in cases of initial skin changes even if changes in behaviour may be subtle or not obvious during examination. To elaborate on the age or extent of chronic lesions, studies involving histopathological examination of skin ulcers can be considered [ 35 , 38 ]. Concerning neural tissue, traumatic neuromas appear not only in shoulder ulcers affecting deep skin layers but also in ulcers affect - ing only superficial layers [ 35 ]. Moreover, traumatic neu -

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s appear not only in shoulder ulcers affecting deep skin layers but also in ulcers affect - ing only superficial layers [ 35 ]. Moreover, traumatic neu - romas have been found in shoulders with evidence of healed ulcers [ 35 , 51 ]. It is commonly accepted that nerve damage may lead to increased activation of peripheral nociceptors and central neuronal excitability, including peripheral and central sensitization [ 56 ]. Moreover, neu - roma formation is likely to initiate chronic neuropathic pain [ 57 ]. ese changes contribute to post-injury hyper - sensitivity, which is measured as hyperalgesia and allo - dynia [ 51 , 58 ]. Hence, a pig that has ulcers in predisposed locations should be examined more frequently for pain- related behaviour and should be considered a candidate for pain relief treatment even if no (acute) compromised skin is visible. In summary, these findings reject the assumptions that nerves in damaged tissues basically cease [ 59 ] and support that both inflammatory and neuropathic pain can occur due to skin ulcers and cause pain in pigs. To emphasize this point again, painful changes in tissue may occur even before they are clinically visible to the observer, and these changes may persist after clinically visible signs have disappeared [ 35 , 46 , 51 , 60 ]. erefore, pigs should be carefully examined and treated for welfare concerns as early as possible, as outlined below. erapy for shoulder ulcers comprises the local appli - cation of zinc ointment [ 49 ], mãnuka honey, or local sprays [ 46 ] or the protection of the affected skin from soft rubber mats [ 44 , 48 , 49 ]. Pain alleviation via NSAIDs should be considered for shoulder ulcers affecting the dermis and certainly for those affecting deeper skin lay - ers [ 61 ]. However, pain

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n via NSAIDs should be considered for shoulder ulcers affecting the dermis and certainly for those affecting deeper skin lay - ers [ 61 ]. However, pain relief without accompanying treatment [effective decompression, early weaning] may have a contradictory effect [ 48 ]. If no pain alleviation is possible or no healing can be achieved, pigs with deep ulcers may need to be euthanized. Euthanasia should be considered when the underlying bones are affected. To avoid reaching this stage of ulceration and secure timely euthanasia in such cases, future studies should elaborate on the timeline of ulcer stages with regard to the appear - ance of chronic pain on the one hand or valid healing signs on the other hand. Studies on healing published this far have shown that skin lesions are present in the majority of shoulder ulcers in sows for at least 2 to 3 weeks and that superficial healing usually occurs within a few weeks after wean - ing. e prominent type of healing is secondary healing [ 62 ]. However, the chance of developing chronic pain

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Page 5 of 17 initiated by traumatic neuroma [ 51 ] and an enhanced risk of developing a shoulder ulcer [ 45 ] again show that healing is often limited by the disappearance of the vis - ible skin lesion. Information about the healing of ulcers in locations other than the shoulder is not available to the authors. When considering the influence of treatment on the healing of shoulder ulcers, attention needs to be devoted to the fact that ulcers rarely develop alone. In this respect, several studies have addressed risk factors such as lame - ness, a low body condition score or the development of shoulder ulcers during previous farrowing [ 39 , 44 , 63 65 ]. Climate conditions, such as moisture in crates and changes in floor types before farrowing, also appear to play a role [ 46 ]. Hence, when assessing the chance of healing or generating a treatment protocol, these factors need to be considered. If underlying causes are neglected (such as a lameness), secondary ulcers in unexpected regions may develop [such as over the ala of the ilium, the head of the femur, the elbow and various locations of the distal leg; see (Additional file S2 for assessment in stable (right side) and Additional file S3 for secondary ulcers (left side of the same pig)), or ulcers in typical locations may develop (Additional file S4 ). In summary, shoulder ulcers evoke several pain mecha - nisms, and an appropriate treatment protocol is needed that may go beyond the consideration of pain relief or rubber mats alone. For detection, examiners need to assess skin and shoulder ulcers in pigs carefully and look for ulcers in unexpected regions when locomotion is impeded or when the body condition score is low. External hernia Hernias are protrusions of tissues or organs (or both) through body walls

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comotion is impeded or when the body condition score is low. External hernia Hernias are protrusions of tissues or organs (or both) through body walls within [internal hernia] or outside the body or compound (external hernia) [ 66 ]. Multiple her - nia types are defined, and they can appear due to natural openings (defects), trauma or lesions of surrounding tis - sue, such as skin or muscles [ 66 68 ]. Umbilical hernias in pigs, however, have attracted the most attention because they have consequences for transport and slaughter [ 66 ]. Topics about umbilical hernias in reviewed papers address behavioural and pain indicators [ 66 ], genetic fac - tors [ 69 ] and surgical aspects [ 75 , 76 ]. Concerning pain sensation in general, umbilical her - nias with intact skin are not necessarily painful [ 62 ]. ey may cause abdominal pain or discomfort [ 69 ], but smaller umbilical hernias without intestinal incarceration or ulcerative skin lesions are likely not painful for the pig. As an indicator of pain, the results elaborate on reduced lying time [ 70 ] and the willingness of pigs to engage in locomotor and social activities [ 66 ]. e latter study revealed no differences between pigs with and without umbilical hernias. However, skin lesions in pigs with umbilical hernias were not reported, and observations were subject to variability. erefore, findings on the will - ingness to engage in activities as an indicator of pain due to umbilical hernias needs to be interpreted with caution. From the perspective of the authors, a promising behav - ioural indicator for pain measurement in pigs, however, might be the time a pig is lying in sternal recumbency, as this position is associated with maximum pressure on the hernia, particularly in hernias where the intestine cannot

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is lying in sternal recumbency, as this position is associated with maximum pressure on the hernia, particularly in hernias where the intestine cannot be repositioned into the abdomen. Painful alteration of the hernia will likely reduce the duration of lying in ster - nal recumbency, which is usually favoured by pigs. Additionally, pain is very likely to compromise animal welfare when ulcerative skin lesions on the outpouch - ing are present [ 38 ]. Ulcerative skin lesions on hernias frequently start to develop from the ventral aspect and are considered painful [ 38 ]. In fact, they are the most frequent complication that lead to euthanasia of pigs affected by umbilical hernia [ 71 ]. e risk for skin ulcer - ation is positively associated with the size of the hernia and is increased in hernias where the intestine cannot be replaced into the abdomen [ 71 ]. us, assessing hernias and accompanying conditions is important for determin - ing further development (also in [ 66 ]). Another case in which pain is very likely to occur is the type of pathologi - cal condition causing the hernia [ 70 ]. e typical patho - logical conditions of hernias include strangulation of the hernia content with insufficient blood supply, obstruc - tion or incarceration of the intestine and adhesions to the intestine or omentum [ 72 , 73 ]. All these complications are associated with severe pain in humans [ 74 ], and it is reasonable to assume that this also applies to other spe - cies [ 72 ]. Surgical repair is an option for the treatment of umbili - cal hernia [ 75 , 76 ], and related translational studies have been published [ 77 ]. However, as criticized in trans - lational studies, pain relief is often not reported even though pain may be observed (also see [ 76 , 77 ]). Like for ulcers

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as criticized in trans - lational studies, pain relief is often not reported even though pain may be observed (also see [ 76 , 77 ]). Like for ulcers in general, pain alleviation should be considered for hernia lesions affecting the dermis, those exceeding a medium size (e.g., a diameter of 2 cm) and, certainly, for deeper skin layers. When an ulcerative skin lesion on a hernia exceeds medium size or affects the subcutis (Additional file S5 ), healing within an acceptable time is unlikely, particularly when the pig is kept without litter, and euthanasia prevents further pain and suffering. Concerning healing, the general processes of the pathology of hernias have been well researched [ 67 , 68 ], and umbilical hernias tend to maintain their basic con - ditions over time [ 66 ]. For a second aspect, namely, the knowledge about the genesis and healing of invagination and adhesions or incarceration and secondary injuries of (umbilical) hernias, publications are rare. However, whether ulcerative skin lesions on hernias result mainly

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Page 6 of 17 from damaging behaviour or whether the healing of skin lesions is compromised by the pressure applied to pro - truded organs has yet to be studied. In this review, several papers reported on post-surgery care [ 75 , 76 ]. In addi - tion, studies on other external hernias, the reporting of pain and the treatment of hernia-associated skin injuries in pigs are neglected in the literature. Moreover, studies addressing umbilical hernias, such as the transcriptome analysis of Souza et al. [ 69 ], do not discuss implications for pain. e study suggested that gene candidates for umbilical hernias may also indicate expression profiles where chronic pain occurs. However, it remains unclear what conditions the pigs and hernias were in (e.g., inflamed, ulcerated) and whether gene-related inferences about the presence of pain could be drawn. Biting lesions Biting lesions caused by damaging behaviour of other ani - mals in the group occur on the tail, ear, flank and vulva. Since there are various definitions for biting behaviour, ranging from incidental chewing to forceful attacks [ 78 ], biting was defined as any biting behaviour of pigs leading to skin damage for this review. Tail biting Tail biting is a frequently observed abnormal behaviour in domestic pigs and is closely associated with welfare and economic concerns [ 79 82 ]. Lesions can range from minor bite marks to loss of the entire tail [ 83 ]. Tail biting and the resulting lesions are connected to increased pain in pigs [ 81 , 84 ] and are linked to local, secondary and sys - temic infections [ 79 , 83 ]. In this regard, this topic is well researched, especially given the questions associated with damaging management procedures such as tail docking. It has been suggested that tail biting is a

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rched, especially given the questions associated with damaging management procedures such as tail docking. It has been suggested that tail biting is a redirected behaviour with a background in unfulfilled exploratory behaviour [ 85 ]. Nevertheless, tail biting is multifactorial, with several other factors having an impact on develop - ment [ 86 , 87 ]. Despite the high research interest, neither standard terms for the act of biting [such as caudophagy, chewing, fanatic attacks, cannibalism] nor final theories explaining the motivation of pigs to engage in damag - ing behaviour are commonly applied or defined [ 78 80 , 88 90 ]. Tissue damage ranges from superficial bite marks to bleeding or encrusted lesions, necrosis, abscesses or even loss of the tail body; this damage can include a loss of the entire tail as well as injuries to the tail root and the surrounding tissue. Repeated biting results in the coinci - dence of acute and chronic tail lesions, as some pigs are bitten multiple times [ 91 ]. According to the degree of damage, (histo-)pathology reveals invasion of inflamma - tory cells and development of granulation and scar tis - sue among common developmental stages [ 57 , 88 , 92 ]. e histopathology of tissue injured by biting has been described in several studies for pigs with docked and non-docked tails [ 57 , 92 ]. Although undocked pigtails are likely to differ from docked tails in neuroanatomical terms, the latter can also be bitten. When discussing pain in this respect, one should consider the proliferation of neurofilaments, including neuromas, in tail tips as well as (pain/inflam - matory) gene adaptation in dorsal root ganglia [ 92 , 93 ]. While neuromas are not necessarily painful when induced by tail docking [ 92 , 94 ], painful

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tory) gene adaptation in dorsal root ganglia [ 92 , 93 ]. While neuromas are not necessarily painful when induced by tail docking [ 92 , 94 ], painful conditions after amputation are associated with coexistent scar tissues, abscesses, haematomas or osteomyelitis [ 95 ], conditions that are likely to occur in tails with severe biting lesions. Tail biting causes wounding of the tail, as well as amputation of part of, or the entire tail, which surely is painful for pigs [ 89 , p.144]. Pain caused by tail bit - ing thus relates to acute pain, and the stimulus can be repeated when victims are bitten again [ 89 , 91 ]. Inflam - mation and infections are often associated with the over - all condition of pigs with bite injuries [ 79 , 96 ], as are signs of chronic stress [ 89 , p. 155]. e tail posture has been examined for its use as an early predictor of upcoming tail biting [ 97 99 ]. How - ever, recent studies indicate that a hanging or tucked-in tail posture does not indicate early damage [ 86 , 100 ]. A hanging tail posture is indicative of tail wounds but not of minor damage, such as bite marks [ 86 , 100 ]. Inflamed wounds at feeding are significantly associated with hang - ing tails [ 86 ]. Nonetheless, hanging or even tucked tails can be found in pigs with no visible signs of damage [ 97 ] and may also be related to stress [ 86 ]. In general, specific postures in animals often cannot be assessed alone but need to be interpreted in combination with the entire body posture or behavioural examinations [ 86 ]. Other studies have evaluated the feeding behaviour of bitten pigs under pain relief such as ketoprofen [ 101 ]. It was found that before the onset of biting, the feeding frequency was reduced, and pain relief, as provided by the applied concentration,

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n [ 101 ]. It was found that before the onset of biting, the feeding frequency was reduced, and pain relief, as provided by the applied concentration, chosen signalling pathway or standalone treatment, seemed to have little effect on the return of feeding behaviour prior to onset [ 101 ]. More research is needed to clarify whether ketoprofen does not resolve stress or restlessness, a behaviour discussed ear - lier in this article as a sign of discomfort or pain (also see [ 96 ]). Another reason might be that other compromising conditions exist that impact feeding behaviour [ 102 ]. In addition to behavioural indices, biomarkers can be used to assess painful conditions in pigs [ 1 ], and several studies have evaluated this topic with respect to tail bit - ing. In general, studies included in this review revealed that inflammatory marker levels tend to increase in bit - ten pigs [ 96 , 103 ]. However, further research is neces - sary to determine whether higher or more systematic

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Page 7 of 17 inflammatory biomarkers are associated with tail bites or severe damage [ 103 , 104 ]. is knowledge is crucial for discussions about healing processes as well as the exacer - bation of diseases. In general, the healing of tail injuries [and pertaining to an outbreak of biting] can be traced macroscopically. In acute wounds, the blood appears fresh and bright red, while in older healing wounds, the blood becomes sticky, dry and dark [ 105 , 106 ]. In the future, progressive dry tis - sue necrosis with eventual partial or total loss of the tail may occur within a few days [ 107 ]. While the initial leak - ing secretions keep the tail constantly moist for healing, they can also attract bacteria and trigger inflammatory processes [ 108 ]. e risk of infection of other organs via the bloodstream, lymphatic system and cerebrospinal fluid is almost always present in tail wounds. In addition to the skin, the tail muscles and tail vertebrae are often affected [ 88 ]. In addition to local infection, systemic spread of bacteria may lead to arthritis or abscess forma - tion in the spine or lung [ 96 , 109 ]. Despite these risks, reliable conclusions about mortality rates in tail-bitten pigs are not easy even though it can be assumed that tail biting leads to significant losses [ 80 , 89 ]. us, tail-bitten pigs need early and thorough examination to determine which therapy and treatment are most appropriate. In cases of tail injuries, local treatment, such as the application of chlortetracycline (CTC) spray [ 110 ] in combination with an analgesic, may be beneficial. Ketoprofen (mind the discussion above) or meloxicam (according to the experience of authors) may be assessed for a fit of treatment in a particular case. If signs of inflammation are present

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or meloxicam (according to the experience of authors) may be assessed for a fit of treatment in a particular case. If signs of inflammation are present (swelling, redness of the tail], additional systemic antibiotic treatment is indicated [ 107 , 112 ] to treat the local infection and prevent secondary infections likely induced by bacteraemia [ 96 , 111 ]. More - over, pigs with severe tail injuries involving partial or total loss of the tail should be moved to a hospital pen, and identified aggressor animals should be removed from the group [ 112 ]. e chances of recovery from tail biting are good if the animals are treated early. In a previous study, a healing rate of 89% was achieved through the provision of additional enrichment materials and removal of the perpetrators [ 112 ]. However, if an infection has occurred, the prognosis for the animal is poor [ 113 ]. Flank biting Flank biting can occur due to damaging behaviour simi - lar to tail and ear biting [ 99 , 114 , 115 ]. e pathology of biting lesions are similar in histopathological terms. Hence, depending on the intensity, depth and involve - ment of bacteria, findings range from superficial epider - mal lesions to deep ulceration [ 116 ]. In general, studies dedicated to flank biting alone are rare [ 99 ]. Following one study in the review, the effects of flank biting on pigs can be described by scoring the lesion (size, freshness, severity) and assessing behavioural indicators. Compared to tail biting, this study found that the tail posture is not a reliable indicator of pain or distress due to flank biting. However, the occurrence of flank injury tended to be associated with the severity and severity of certain tail injuries (p.11). Apart from the reviewed publications, deep lesions and

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injury tended to be associated with the severity and severity of certain tail injuries (p.11). Apart from the reviewed publications, deep lesions and ulcerations of flank lesions should be considered painful, as discussed in the previous chapter. However, findings about pain-specific behavioural indicators for flank bit - ing, treatment or healing processes have yet to be pub - lished and discussed in future studies. Ear lesions Ear biting refers to the oral manipulation of ear tips or bodies and can result from damaging behaviour [ 115 ]. An associated pathology is porcine ear necrosis (PEN), which can result from initial bite lesions, although other aetiologies are discussed [ 117 ]. is chapter subsumes PEN and ear biting as ear lesions , as both entities repre - sent spontaneously occurring injuries, and the terminol - ogy used in related papers is often vague [ 117 ]. Furthermore, the [histo-]pathological characteristics of ear lesions are a well-known problem in pig produc - tion and have long been assessed [ 116 , 118 ]. In addition to developing like other bite lesions [see previous chap - ters], blood vessel occlusion induced by bacterial toxins is considered to be the main cause of epidermal damage and necrosis [ 117 ]. Irrespective of the cause, mild and superficial lesions to severe necrosis and substantial loss of ear bodies may occur. Although tissue damage and necrosis in body parts are likely to be accompanied by pain, none of the papers discusses this subject in particular. Among the papers examining ear biting, however, one study developed an ethogram for biter and bitten pigs and studied behaviours such as pain-related vocalization [ 115 ]. e findings from this study suggest that ear pulling, head shaking and, to a lesser extent, quick

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behaviours such as pain-related vocalization [ 115 ]. e findings from this study suggest that ear pulling, head shaking and, to a lesser extent, quick bites invoke greater pain, as indi - cated by the avoidance behaviour and screaming of the bitten pig [ 115 , p. 34]. Moreover, a study on behavioural and physiological responses to damaging procedures was integrated [ 119 ]. e findings from this study sug - gest that a combination of head shaking, ear scratching, shivering and grunting indicates pain after ear tagging or notching (p.92). Apart from behavioural parameters, studies concern - ing ear lesions often use scoring systems similar to those used for tail lesions. For example, clinical or histological examinations concerning the size, freshness, depth or loss of the ear surface have been performed (for an over - view see [ 117 ]). Interestingly, none of the scores or stages of severe lesions were discussed in relation to pain.

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Page 8 of 17 In comparison to the treatment of such lesions, the healing processes and prognoses depend on the particu - lar lesion state and are rarely discussed. In general, stages ranging from re-epithelization with intermediate clinical signs of crusting and leakage similar to tail bites to a final, total loss of the ear are possible [ 117 , 118 ]. Treatment of ear-bitten pigs depends, of course, on the stage of the lesion. Separating pigs to a hospital pen, providing materials to reduce damaging behaviour and mitigating risk factors are generally advised. Interestingly, providing antibiotics is a discussed strategy due to the assumed involvement of bacteria in the onset or exacer - bation of a lesion [ 117 ]. Although this topic has not been discussed previously, pain relief for pigs with substantial ear lesions should also be considered. However, further research is needed to examine the influence of medica - tions such as NSAIDs on the healing process and welfare of pigs with ear lesions [ 115 , 117 ]. Vulva biting Vulva biting is a behaviour observed in group-housed sows and is often associated with factors such as frustra - tion, competition for food and limited access to resources [ 120 ]. It serves as a commonly used indicator of sow welfare. e swelling of the vulva in late pregnancy increases vulnerability to attacks [ 121 ], leading to enhanced occur - rence during this period [ 122 ]. Once the vulva is bitten, the increasing swelling, discolouration, and potential presence of blood and pus attract further attention, thereby exacerbating pain [ 120 ]. Sows show signs of self- protective behaviour by sitting down in feeding queues, likely to avoid being bitten by the following sow [ 123 ] or by keeping the time to feed at the trough particularly short [

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ng down in feeding queues, likely to avoid being bitten by the following sow [ 123 ] or by keeping the time to feed at the trough particularly short [ 124 ], while bitten sows react very sensitively and try to flee the situation [ 120 ]. Taken together, these find - ings indicate that vulvar bites cause considerable pain to sows. However, in terms of pain alleviation, the signifi - cance of vulva biting lesions has often been disregarded, and it is not unlikely that this is caused by a misunder - standing. An increase in the nociceptive threshold has been shown during late pregnancy and parturition not only in women but also in sows [ 125 ], perhaps as an endogenous defence against the pain of parturition [ 126 ]. is mechanism might facilitate pain alleviation during parturition, but there is no evidence that vulvar lesions induced by biting are generally not painful. e severity of the wounds can vary, ranging from fresh wounds to old scars, and complications such as secondary infections can occur [ 127 ]. Skin-perforating lesions showing signs of inflammation are likely painful for affected sows. In severe cases, vulva biting can result in extensive scarring and disfigurement, possibly caus - ing considerable pain during subsequent farrowing [ 128 ]. Timely identification and removal of affected sows from the group, along with appropriate analgesic treatment, are necessary to minimize pain and further damage [ 122 ]. CNS (meningitis) Meningitis is a common disease in pigs and is considered to cause pain [ 6 ]. Among the reviewed papers, only one addressed pain in CNS-related diseases [ 129 ]. In general, Streptococcus suis is the most important pathogen that generates meningitis worldwide, and S. suis infections affect 5- to 10-week-old pigs in most cases.

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eptococcus suis is the most important pathogen that generates meningitis worldwide, and S. suis infections affect 5- to 10-week-old pigs in most cases. Clinical signs of this infection may include septi - caemia and acute death, meningitis, polyarthritis, poly - serositis, and valvular endocarditis [ 130 , 131 ]. Although most weaned piglets carry S. suis strains, few carry viru - lent strains capable of inducing the disease. In peracute cases, pigs may die without any preceding clinical signs. Otherwise, pigs may exhibit incoordination and adoption of unusual postures in early stages, which soon progress to inability to stand, paddling, opisthotonus, convulsions, and nystagmus. Other clinical signs may also be observed [ 132 ], but early recognition and immediate parenteral treatment with an appropriate antibiotic with or without an anti-inflammatory agent maximizes pig survival [ 133 ]. As S. suis is also well known as a zoonotic agent, assumptions about pain related to its meningitis can be supported by manifestations in humans. Clinically, head - ache, fever, vomiting, nervous disorders, and later hearing loss can be observed most frequently [ 134 ]. According to different systematic reviews, fever, headache and neck stiffness also appear to be the most prominent clinical signs [ 135 , 136 ]. Headache certainly presents a sort of pain, but as shown in a case study of a Persian cat, severe mid-lumbar back pain and extreme reluctance to move were the only abnormalities on physical and neurological examinations [ 137 ]. Hence, pain induced by S. suis infec - tions may be obvious not only in pigs with lameness but also in those with meningitis [ 6 ], as described in human medicine and other species. In pig practice, anti-inflammatory drugs are recom - mended for

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also in those with meningitis [ 6 ], as described in human medicine and other species. In pig practice, anti-inflammatory drugs are recom - mended for the treatment of meningitis because in addition to their anti-inflammatory effects, they can reduce pain and have antipyretic effects [ 138 ]. How - ever, the effects of treatment with analgesics in cases of S. suis infection in pigs have rarely been documented. A study evaluated the effect of buprenorphine treatment in an S. suis infection model in pigs [ 129 ] 1 . e intrave - nous administration of S. suis to 6-week-old piglets led to severe disease in approximately 50% of the animals. Suppurative meningoencephalitis and arthritis as well as fibrino-suppurative endocarditis were the main findings 1 In Germany, the opioid analgesic buprenorphine is not licenced for use in pigs.

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Page 9 of 17 at necropsy. For pain scoring, the following parameters were assessed: feed intake, lameness, movement time, get-and-scare up, pain vocalization, and behaviour (fresh, damped, listlessness, central nervous disorder [tetanic spasm, opisthotonus, convulsion]). Additionally, special signs (kyphosis, tremor) were evaluated. e adminis - tration of 0.05 mg of buprenorphine/kg for 5 days i.m. every 8 h post infection did not prevent high clinical or pain scores in affected animals and did not result in sub - stantially lower mean clinical or pain scores. Hence, the chosen protocol of buprenorphine application does not prevent severe distress or pain in this infection model [ 129 ]. Respiratory tract Infections of the respiratory tract are among the most common health problems in pig husbandry. In addition to the general negative impact on pig health and wel - fare, respiratory tract infections can cause reduced feed intake, decreased daily weight gain and increased mor - tality. Symptoms of respiratory tract infections in pigs include reduced general condition, fever, dyspnoea, pain - ful breathing (sometimes in the dog sitting position), coughing, sneezing, nasal discharge, cyanosis, reduced feed intake [anorexia], reduced daily weight gain, and, in the worst case, death [ 139 ]. Respiratory infections not only impact the lungs but also affect the trachea and nasal cavities. Pneumonia and/ or bronchopneumonia and pleurisy are the main find - ings in this context in the affected pigs at slaughterhouses [ 140 ]. Even though respiratory tract infections are common in pigs worldwide, there is a lack of literature concerning pain caused by respiratory tract infections in pigs at every age. As stated by Pessoa et al., respiratory tract infec - tions are likely to

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concerning pain caused by respiratory tract infections in pigs at every age. As stated by Pessoa et al., respiratory tract infec - tions are likely to have a significant negative impact on pig welfare ([ 140 ], p.1), although such an effect is rarely considered in the literature. Indeed, studies on indicators of actual pain followed by respiratory tract infections and the potential impact on pig welfare are missing. is is all the more surprising because, in a survey by Ison and Rutherford, farmers and veterinarians rated respiratory diseases in pigs as painful and scored the expected pain with 5.1 on an 11-point scale [ 26 ]. e rec - ognition and management of pain was assessed as impor - tant in this study, and many participants in the survey expressed an interest in identifying pain in pigs as well as the treatment options available. However, information on pain in relation to por - cine respiratory diseases is limited to studies on por - cine pleuropneumonia caused by Actinobacillus (A.) pleuropneumonia . For instance, infections induced by A. pleuronpneumoniae , which can cause necrotizing pneumonia, fibrinous pleurisy, pulmonary oedema, and dyspnoea, are associated with severe thoracic pain [ 141 ]. erefore, careful monitoring and early intervention involving euthanasia are recommended to avoid unneces - sary suffering [ 141 ]. Furthermore, Swinkels et al. showed the beneficial effects of Ketoprofen in addition to antibi - otics on recovery rates and feed intake in pigs infected with A. pleuronpneumoniae [ 142 ]. Despite the lack of published data on pain associated with pulmonary diseases in pigs, pain is undoubtedly one of the cardinal symptoms of any inflammatory response and thus also of respiratory tract infections. erefore, it can be assumed that

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s undoubtedly one of the cardinal symptoms of any inflammatory response and thus also of respiratory tract infections. erefore, it can be assumed that pigs experiencing respiratory tract infections suffer pain. In addition, noxious gases released from pig faeces, such as atmospheric ammonia, can irritate even healthy respiratory tracts. Poor air quality increases the risk of respiratory diseases by irritating the epithelium and even causing cilia loss/function [ 143 ]. If given the choice, young pigs would more likely choose to stay in areas con - taining no atmospheric ammonia than in areas with even lower concentrations (10 20 ppm) [ 144 ]. Furthermore, Jones et al. found that pigs left areas where ammonia was present after approximately 35 min [ 144 ]. Because of the lack of immediate aversion, the authors concluded that not the odour of ammonia caused the pigs to leave these areas but rather the discomfort caused by the gas. While a respiratory tract irritated by (high) levels of atmospheric ammonia is by definition not a disease, it should not be underestimated concerning the resulting discomfort and even damage and pain and the potential infections of the respiratory tract that could follow. Gastrointestinal tract Pain resulting from various gastrointestinal diseases in humans is an important research field in which the spe - cies pig is widely used as an animal model. Some infor - mation about pain in gastrointestinal diseases in pigs can therefore be deduced from neuroanatomical and physi - ological findings in these translational studies. e intes - tinal nervous system in humans is mainly autonomic but is in part controlled centrally by extrinsic innervation via three pathways: parasympathetic and sympathetic effer - ent innervation and sympathetic

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ut is in part controlled centrally by extrinsic innervation via three pathways: parasympathetic and sympathetic effer - ent innervation and sympathetic afferent innervation. It is known that pain stimuli from the stomach and intes - tine are conducted by afferent nerves to the brain [ 145 ]. In contrast to studies in humans, pain assessment studies of gastrointestinal disorders in pigs are rare. In most studies, important animal-based indicators, such as behaviour and vocalization, are used to assess dis - tress without differentiating pain as a stressful condition [ 146 ]. In gastrointestinal diseases, behavioural scoring for pain assessment can be considered more meaning - ful than vocalization, which has been used for acute pain

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Page 10 of 17 combined with extreme stress, e.g., during surgical cas - tration [ 147 , 148 ]. Rectal prolapse is a specific disorder of the gastro - intestinal tract that can be differentiated by its length and obvious injury to the mucosa. Due to acute painful events, when the non-physiologically exposed mucosa is injured or destroyed, pain assessment might be easier than in other gastrointestinal diseases. Several stress bio - markers, including cortisol and salivary alpha-amylase, have been used to assess pain during rectal prolapse to validate a modified pain perception protocol published by Morton and Griffith [ 6 , 147 ]. A score from 0 to 20 was based on the patient s appearance and body condition score, clinical signs and behaviour without any stimu - lus and response to external stimuli [ 149 ]. A combined score equal to or greater than 5 indicated not only pain but also distress and discomfort. Pain, distress and dis - comfort were recorded for pigs with a prolapse length of 6+-2.5 cm but not for pigs with smaller prolapses (3.0+- 4.3 cm). e scoring outcome was related to several bio - markers [ 147 ]. In other gastrointestinal diseases, pain assessment can be biased by inappetence and other disease-related behaviours [ 6 ]. Gastrointestinal diseases were scored as moderate by veterinarians and farmers, ranging from 4.5 to 5.6 on a 10-point pain scale based on their experience [ 26 ]. Assessment of pain relies mainly on behavioural characteristics [ 150 ]. Behavioural indices for the assess - ment of acute pain have been described for piglets after intra-abdominal injection, which can cause abdominal pain. Typical pain-related behaviours such as rubbing the abdomen against the floor and huddling (i.e., tuck - ing three or more legs under the body) have

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n. Typical pain-related behaviours such as rubbing the abdomen against the floor and huddling (i.e., tuck - ing three or more legs under the body) have also been observed [ 119 , p.89]. In addition, control pigs and treated pigs differed with respect to being awake without mov - ing, as abdominal pain seems to be quite subtle, awake inactive behaviour , (119, p. 91). According to the experi - ence of the author team, metamizol may be assessed in a given case given its spasmolytic characteristics [ 198 , 199 ]. Gastric ulcers in sows and in finisher pigs are impor - tant welfare issues in swine production and occur at varying rates among countries and studies [ 151 ]. In fin - isher pigs with gastric ulcers, behavioural changes were observed and interpreted as pain-related behaviour. Pigs with gastric ulcers spend significantly more time walk - ing and standing than their pen mates and tend to rest less and avoid lying on the left side of the body [ 152 ]. In contrast, behavioural observation of fattening pigs two days before slaughter and inspection of gastric lesions in the respective pigs resulted in more lying in contact with other pigs, more manipulation of pen mates and longer eating times in affected pigs [ 153 ]. In translational medi - cine, the acetic acid ulcer model is well established for studying interventions for gastric ulcers in swine [ 154 ]. e results obtained in this model revealed the impact of antral ulcerations on the intramural nerves responsi - ble for the function of the pyloric sphincter. In humans, this painful disease is characterized by a malfunction of gastric emptying [ 154 ]. In this experimental pig model for gastric ulcers, neuronal responses were studied. e expression of the neuropeptide galanin, which is widely

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154 ]. In this experimental pig model for gastric ulcers, neuronal responses were studied. e expression of the neuropeptide galanin, which is widely distributed in the gastrointestinal tract and modulates the enteric nerve response, among other biological func - tions, was also examined in inferior vagal neurons in pigs [ 155 ]. Neuropeptides such as galanin are synthetized by primary afferent neurons and are involved in visceral pain signalling. In swine with experimentally induced gastric ulcers, galanin expression was significantly greater than that in healthy control animals, supporting the assump - tion that gastric ulcers are painful [ 155 158 ]. Abdominal pain is a symptom of various anatomical and functional gut alterations, such as intestinal inflammation, par - tial blockage and gut distension. Pain is considered the most important symptom in 50 70% of patients with inflammatory bowel disease [ 159 ]. It is also known that persistent changes in afferent neurons due to sensitized sensory pathways and despite resolved inflammation can lead to persistent pain [ 159 ]. Enteric inflammation in swine due to various pathogens can lead to pathomor - phological inflammatory and functional changes similar to those in humans; thus, the occurrence of abdominal pain can be hypothesized, at least in severe cases [ 160 ]. e ileocecal valve is innervated by dorsal root ganglia neurons, and specific bacterial lipopolysaccharides can influence the neurochemical reactivity to neuropeptides at this location [ 161 ]. It can therefore be hypothesized that swine infectious enteric diseases impact neurophysi - ological mechanisms and therefore pain signalling. Urinary tract infections Inflammatory processes in the porcine urinary tract of sows are mostly caused by

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cal mechanisms and therefore pain signalling. Urinary tract infections Inflammatory processes in the porcine urinary tract of sows are mostly caused by facultative pathogens such as Escherichia coli , streptococci, staphylococci, Proteus spe - cies, Klebsiella species and Trueperella ( Actinomyces) pyogenes [ 162 , 163 , 196 ]. Lesions due to nonspecific uri - nary tract infections [UTIs] are usually restricted to the urinary bladder and cause only mild clinical signs. Con - tamination and ascent of the urethra by faecal microbiota is possible but more likely in females than in males. e clinical signs in sows with cystitis include urinary changes in most cases. Some pigs urinate in small quanti - ties with straining or be observed in a dog-sitting posi - tion [ 162 , 164 ]. General signs of illness become apparent if cystitis is followed by ascending infection to the kid - neys and the development of pyelonephritis, resulting in uraemia [ 165 167 ].

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Page 11 of 17 e clinical symptoms may depend on the involved pathogen. For example, generalized infection of the uri - nary tract is often caused by Actinobaculum suis , which is carried by boars and can be transmitted to sows dur - ing mating. Clinical signs may develop 2 3 weeks after mating or may be delayed until farrowing. Affected sows or gilts may die suddenly or be found ill, depressed, or thirsty with hunched backs. Haematuria is the main sign of the acute phase, together with frequent and pain - ful voiding and dysuria. Later, the affected animals are uraemic; they pass bloodstained, purulent urine with or without vulval discharge; and they exhibit inappe - tence and weight loss. Typical cases exhibit the following symptoms: hypothermia below 38 °C, a heart rate greater than 120, painful abdomen, polypnea, cyanosis, ataxia, and more rarely generalized tremor. Moreover, clini - cally affected sows frequently die from renal failure [ 165 , 167 169 ]. Regarding behavioural changes, pain due to UTI can be expected, especially if haemorrhagic cystitis and pyelo - nephritis are present. In the review, however, no studies elaborating on pain in relation to UTI in pigs were found. is is astonishing since much about the pathophysiology of the urinary tract, including the neuronal patterns of pigs, is known and appears to perform similarly to what has been done in humans [ 170 , 171 ]. e symptoms of acute cystitis in humans are similar and include dysuria with or without increased frequency, urgency, suprapubic pain, cloudy urine, or haematuria [ 172 175 ]. Dysuria is defined as the sensation of pain and/or burning, stinging, or itching of the urethra or urethral meatus associated with urination [ 176 ]. Hence, it must be considered that pigs with

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and/or burning, stinging, or itching of the urethra or urethral meatus associated with urination [ 176 ]. Hence, it must be considered that pigs with bacterial cystitis can also experience some pain at least when urinating. In addition to the lack of studies about pain indicators related to UTIs, very little is known about pain treatment for cystitis in sows. In addition to antibiotic treatment, Stirnimann et al. recommended the administration of a spasmolyticum/analgeticum [Metamizole], as the results obtained for acute UTIs in sows were better than those obtained with antibiotic treatment alone [ 165 , 166 ]. Mastitis and teat lesions Mastitis is an inflammatory process of the mammary gland and is caused by bacterial infections and/or trau - matic teat lesions. Acute mastitis affects sows mainly within 3 days after farrowing and is accompanied by sys - temic signs (fever, reduced feed intake) and local signs of inflammation (oedema, skin congestion) [ 177 ]. Risk factors for the occurrence of teat injuries include the presence or absence of tooth resection in piglets, differ - ent methods of tooth resection, housing systems (espe - cially flooring), litter size, piglet-related management strategies, milk supply and barren environments [ 178 ]. Interestingly, posterior mammary complex pairs are often affected, potentially due to sows injuring them - selves with hind claws [ 179 181 ] or likely to have lower milk production in the caudal glands [ 182 ]. Piglets work - ing harder at the rear udder due to lower milk supply might lead to more accidental biting. Additionally, the distinct nervous supply of pair number 7 could decrease their sensitivity to pain, resulting in slower pain reactions to injury [ 179 ]. e pathogen involved in mastitis may influence

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number 7 could decrease their sensitivity to pain, resulting in slower pain reactions to injury [ 179 ]. e pathogen involved in mastitis may influence the set of clinical signs in a sow. In general, however, masti - tis is considered to be a postparturient disorder complex, such as postpartum dysgalactia syndrome (PPDS) (for - merly referred to as mastitis-metritis-agalactiae (MMA)), rather than a distinct disease entity (cf. [ 183 ]). is approach makes it difficult to define pain-specific behav - iour, although mastitis in sows is generally considered painful by veterinarians and farmers [ 6 , 26 ], similar to what is the case for cows [ 184 , 185 ]. Regarding mammary skin lesions, histological findings and bacterial identifica - tion revealed dermal and subcutaneous pyogranuloma - tous lesions due to infection with Staphylococcus aureus and dermal abscesses associated with Trueperella pyo - genes . e glandular tissue of the mammary was unaf - fected, which ruled out mastitis [ 179 ]. Another study found an association between mammary lesions and Pseudomonas spp. , primarily affecting the dermis with potential gland involvement. Inflammation is driven by lymphocytes via the IL-1β/IL-6 pathway, partly involving T cells [ 186 ]. Recent evidence also links IL-1β to inflam - mation and pain [ 187 ]. Sows in pain may exhibit various avoidance behaviours, including attempting to move away from piglets, rest - lessness, and alterations in posture, such as dog sitting or increased ventral lying patterns [ 188 191 , 197 ]. ey may also modify their maternal behaviours, potentially reducing nursing frequency and increasing aggression towards piglets [ 192 , 193 ]. e prevalence of teat lesions may range from 3.3 to 19% and may not be detected by inspection alone

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creasing aggression towards piglets [ 192 , 193 ]. e prevalence of teat lesions may range from 3.3 to 19% and may not be detected by inspection alone [ 186 ]. Summarizing, it is striking that pain due to mastitis and teat lesions in sows are (still) only marginally discussed in the reviewed literature [ 183 , 186 ]. For pain mitigation in mastitis, treatment with an NSAID (flunixin, meloxicam) combined with antibiot - ics and oxytocin is suggested to be effective at improving clinical conditions [ 194 ]. Although farmers may tend to treat severely diseased pigs [ 26 ], another study found that farmers rated mastitis to be the second most frequent reason for the administration of NSAIDs [ 30 ]. NSAIDs are rather effective at mitigating inflamma - tion than pain; however, the authors generally indicate an overall improvement in the recovery of the animals dur - ing treatment [ 26 , 183 ]. However, no further knowledge

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Page 12 of 17 about the healing processes of mastitis and udder pathol - ogies is available, although further study is needed to avoid related pain (cf. [ 186 ). Discussion and conclusion e results of the review emphasize that pigs experi - ence pain due to spontaneously occurring diseases and injuries, but systematic knowledge about this topic is scarce. On the one hand, there is a lack of publica - tions about certain topics, such as flank biting. On the other hand, certain publications elaborate on topics that involve pain indicators, but discussions neglect the implications of results for pain identification, measure - ment and treatment. e last point is true for research in veterinary as well as human medicine generated for translational interest. Hence, one core implication of the review is that more systematic research on pain in pigs is needed for rare diseases (such as UTIs) and topics that were excluded in our reviews such farrowing in sows (focus on reproduction management). Another implica - tion is that conducted research should involve standard - ized protocols to document, analyse and share results on pain detection beyond the project timeframe. Creating a standardized protocol is indeed another core implication of this review. e findings of this review suggest that a standardized protocol would comprise the observation of validated pain identification measures of different kinds (behavioural, biomarkers) over time and in relation to administered pain treatment. Based on a set of compa - rable studies, it will be possible to validate these assump - tions and enhance the evidence about pain in pigs in the future. With regard to evidence, it must be considered that the findings in this article originate from a scoping review without addressing the

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in the future. With regard to evidence, it must be considered that the findings in this article originate from a scoping review without addressing the evidence level or risk of bias [ 3 , 195 ]. Furthermore, the search strings contained exclu - sion criteria (such as the term NOT ) which may have excluded relevant results. In the future, systematic reviews weighting results based on evidence and quality of the sample size and statistics are needed once enough papers are available. Irrespective of statistical significance, the review and synthesis of publications show that pain in pigs due to spontaneously occurring diseases and injuries is often perceived, measured and treated to the benefit of indi - vidual pigs. It is imperative for veterinarians and farmers to assure that pigs do not suffer from unnecessary pain that can be relieved. e results of this study invite read - ers to reconsider in each patient whether pain and related indicators are present and how to resolve the condition to ensure the welfare of individual pigs. Supplementary Information The online version contains supplementary material available at h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 4 0 8 1 3 - 0 2 5 - 0 0 4 2 0 - 1 . Supplementary Material 1 Supplementary Material 2 Acknowledgements not applicable. Author contributions JK designed, drafted, analysed, interpreted and revised, KD analysed, interpreted and revised, MM analysed, interpreted and revised, JR analysed, interpreted and revised, LT analysed and revised; IE analysed and revised, NK analysed and revised, LK revised, IHP analysed and revised, MW analysed and revised, SK revised, EGB designed, drafted, analysed, interpreted and revised. Funding Open Access funding enabled and organized by Projekt DEAL. This work is

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SK revised, EGB designed, drafted, analysed, interpreted and revised. Funding Open Access funding enabled and organized by Projekt DEAL. This work is nancially funded by the German Federal Ministry of Food and Agriculture (BMEL) based on a decision of the Parliament of the Federal Republic of Germany, granted by the Federal O ce for Agriculture and Food (BLE; grant number 28 N-2-008-01 CARE-PIG ). Data availability No datasets were generated or analysed during the current study. Declarations Ethics approval and consent to participate not applicable. Consent for publication not applicable. Competing interests The authors declare no competing interests. Received: 8 February 2024 / Accepted: 17 January 2025 References 1. Kschonek J, Twele L, Deters K, Miller M, Reinmold J, Emmerich I et al. Part I: understanding pain in pigs-basic knowledge about pain assessment, mea - sures and therapy. Porc Health Manag. 2025. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 4 0 8 1 3 - 0 2 5 - 0 0 4 2 1 - 0 . 2. Tricco AC, Lillie E, Zarin W, O Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for scoping reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467 73. h t t p s : / / d o i . o r g / 1 0 . 7 3 2 6 / M 1 8 - 0 8 5 0 . 3. Munn Z, Peters MDJ, Stern C, Tufanaru C, McArthur A, Aromataris E. Sys - tematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018;18(1):143. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 1 2 8 7 4 - 0 1 8 - 0 6 1 1 - x . 4. Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S et al. The revised IASP de nition of pain: Concepts, challenges, and compromises. PMC. 2021; PMC7680716, NIHMSID: NIHMS1596925. 5. Herskin MS, Giminiani

chunk 46 · 184 tokens

al. The revised IASP de nition of pain: Concepts, challenges, and compromises. PMC. 2021; PMC7680716, NIHMSID: NIHMS1596925. 5. Herskin MS, Giminiani PD. Pigs in pain-causes, mechanisms, and possibilities for future development. J Anim Sci. 2017;95(3). 6. Ison SH, Clutton RE, Di Giminiani P, Rutherford KM. A review of Pain Assess - ment in pigs. Front Vet Sci. 2016;3:108. h t t p s : / / d o i . o r g / 1 0 . 3 3 8 9 / f v e t s . 2 0 1 6 . 0 0 1 0 8 . 7. Schrader L, Czycholl I, Krieter J, Leeb C, Zapf R, Ziron M, Tierschutzindika - toren. Leitfaden für die Praxis - Schwein: Vorschläge für die Produktionsrich - tungen Sauen, Saugferkel, Aufzuchtferkel Und Mastschweine. KTBL- Sonderverö entlichung. 12617. Darmstadt: KTBL; 2016.

chunk 47 · 448 tokens

Page 13 of 17 8. Zhang Z, Zhang H, He Y, Liu T. A review in the Automatic detection of pigs Behavior with sensors. J Sens. 2022. h t t p s : / / d o i . o r g / 1 0 . 1 1 5 5 / 2 0 2 2 / 4 5 1 9 5 3 9 . 9. Ala-Kurikka E, Heinonen M, Mustonen K, Peltoniemi O, Raekallio M, Vainio O et al. Behavior changes associated with lameness in sows. 2017:193; 15 20. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 7 . 0 3 . 0 1 7 10. Heinonen M, Peltoniemi O, Valros A. Impact of lameness and claw lesions in sows on welfare, health and production. Livest Sci. 2013;156(1):2 9. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 3 . 0 6 . 0 0 2 . 11. Meijer E, van Nes A, Back W, van der Staay FJ. Clinical e ects of buprenorphine on open eld behaviour and gait symmetry in healthy and lame weaned piglets. Vet J. 2015;206(3):298 303. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 1 5 . 1 0 . 0 1 6 . 12. Pairis-Garcia MD, Johnson AK, Stalder KJ, Abell CA, Karriker LA, Coetzee JF et al. Behavioural evaluation of analgesic e cacy for pain mitigation in lame sows. Anim Welf, 24:193 99. h t t p s : / / d o i . o r g / 1 0 . 7 1 2 0 / 0 9 6 2 7 2 8 6 . 2 4 . 1 . 0 9 3 13. Parsons RL, Millman ST, Coetzee JF, Karriker LA, Mohling CM, Pairis-Garcia MD, et al. Sow behavioral responses to transient, chemically induced synovitis lameness. Acta Agriculturae Scand Sect Anim Sci. 2015;65(2):122 5. h t t p s : / / d o i . o r g / 1 0 . 1 0 8 0 / 0 9 0 6 4 7 0 2 . 2 0 1 5 . 1 1 1 0 6 1 7 . 14. Conte S, Bergeron R, Gonyou H, Brown J, Rioja-Lang FC, Connor ML, et al. Use of an analgesic to identify pain-related indicators of lameness in sows. Livest Sci. 2015;180:203 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i

chunk 48 · 446 tokens

c to identify pain-related indicators of lameness in sows. Livest Sci. 2015;180:203 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 5 . 0 8 . 0 0 9 . 15. Grégoire J, Bergeron R, D Allaire S, Meunier-Salaün MC, Devillers N. Assess - ment of lameness in sows using gait, footprints, postural behaviour and foot lesion analysis. Animal. 2013;7(7):1163 73. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 3 0 0 0 0 9 8 . 16. Fitzgerald RF, Stalder KJ, Karriker LA, Sadler LJ, Hill HT, Kaisand J, et al. The e ect of hoof abnormalities on sow behavior and performance. Livest Sci. 2012;145(1):230 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 2 . 0 2 . 0 0 9 . 17. Madec F, Cariolet R, Dantzer R. Relevance of some behavioural criteria con - cerning the sow (motor activity and water intake) in intensive pig farming and veterinary practice. Ann Rech Vet. 1986;17(2):177 84. h t t p s : / / h a l . s c i e n c e / h a l - 0 0 9 0 1 6 4 6 . 18. Bos EJ, Nalon E, Maes D, Ampe B, Buijs S, van Riet MMJ, et al. E ect of locomo - tion score on sows performances in a feed reward collection test. Animal. 2015;9(10):1698 703. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 5 0 0 1 2 7 5 . 19. Anil SS, Anil L, Deen J. E ect of lameness on sow longevity. Am Vet Med Assoc. 2009;235(6):734 8. h t t p s : / / d o i . o r g / 1 0 . 2 4 6 0 / j a v m a . 2 3 5 . 6 . 7 3 4 . 20. Dijkhuizen AA, Krabbenborg RMM, Huirne RBM. Sow replacement: a compari - son of farmers actual decisions and model recommendations. Livest Prod Sci. 1989;23(1):207 18. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / 0 3 0 1 - 6 2 2 6 ( 8 9 ) 9 0 0 1 5 - 8 . 21. Pluym L, Van Nu el A, Maes D. Treatment and prevention of

chunk 49 · 448 tokens

t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / 0 3 0 1 - 6 2 2 6 ( 8 9 ) 9 0 0 1 5 - 8 . 21. Pluym L, Van Nu el A, Maes D. Treatment and prevention of lameness with special emphasis on claw disorders in group-housed sows. Livest Sci. 2013;156(1):36 43. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 3 . 0 6 . 0 0 8 . 22. Anil SS, Anil L, Deen J. Evaluation of patterns of removal and associations among culling because of lameness and sow productivity traits in swine breeding herds. J Am Vet Med Assoc. 2005;226(6):956 61. h t t p s : / / d o i . o r g / 1 0 . 2 4 6 0 / j a v m a . 2 0 0 5 . 2 2 6 . 9 5 6 . 23. Jensen TB, Bonde MK, Kongsted AG, Toft N, Sørensen JT. The interrelation - ships between clinical signs and their e ect on involuntary culling among pregnant sows in group-housing systems. Animal. 2010;4(11):1922 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 0 0 0 1 1 0 2 . 24. Anil SS, Anil L, Deen J. Challenges of pain assessment in domestic animals. J Am Vet Med Assoc. 2002;220(3):313 9. h t t p s : / / d o i . o r g / 1 0 . 2 4 6 0 / j a v m a . 2 0 0 2 . 2 2 0 . 3 1 3 . 25. Whalin L, Pairis-Garcia M, Proudfoot K, Stalder K, Johnson A. Validating behav - ioral sampling techniques for lame sows administered unixin meglumine and meloxicam. Livest Sci. 2016;191:103 7. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 6 . 0 7 . 0 1 7 . 26. Ison S, Rutherford K. Attitudes of farmers and veterinarians towards pain and the use of pain relief in pigs. Vet J. 2014;202(3):622 7. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 1 4 . 1 0 . 0 0 3 . 27. Meijer E, Oosterlinck M, van Nes A, Back W, van der Staay FJ. Pressure mat analysis of naturally occurring lameness in young pigs

chunk 50 · 448 tokens

. 1 0 . 0 0 3 . 27. Meijer E, Oosterlinck M, van Nes A, Back W, van der Staay FJ. Pressure mat analysis of naturally occurring lameness in young pigs after weaning. BMC Vet Res. 2014;10(1):193. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 1 2 9 1 7 - 0 1 4 - 0 1 9 3 - 8 . 28. Conte S, Bergeron R, Gonyou H, Brown J, Rioja-Lang FC, Connor L, et al. Mea - sure and characterization of lameness in gestating sows using force plate, kinematic, and accelerometer methods. J Anim Sci. 2014;92(12):5693 703. h t t p s : / / d o i . o r g / 1 0 . 2 5 2 7 / j a s . 2 0 1 4 - 7 8 6 5 . 29. Main DC, Clegg J, Spatz A, Green LE. Repeatability of a lameness scoring system for nishing pigs. Vet Rec. 2000;147(20):574 6. h t t p s : / / d o i . o r g / 1 0 . 1 1 3 6 / v r . 1 4 7 . 2 0 . 5 7 4 . 30. Wilson R, Holyoake P, Cronin G, Doyle R. Managing animal wellbeing: a preliminary survey of pig farmers. Aust Vet J. 2014;92(6):206 12. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / a v j . 1 2 1 6 9 . 31. Friton GM, Philipp H, Schneider T, Kleemann R. Investigation on the clinical e cacy and safety of meloxicam (Metacam) in the treatment of non- infectious locomotor disorders in pigs. Berl Munch Tierarztl Wochenschr. 2003;116(9 10):421 6. 32. Pairis-Garcia MD, Johnson AK, Abell CA, Coetzee JF, Karriker LA, Millman ST, et al. Measuring the e cacy of unixin meglumine and meloxicam for lame sows using a GAITFour pressure mat and an embedded microcomputer- based force plate system. J Anim Sci. 2015;93(5):2100 10. h t t p s : / / d o i . o r g / 1 0 . 2 5 2 7 / j a s . 2 0 1 4 - 8 7 9 6 . 33. Mohling CM, Johnson AK, Coetzee JF, Karriker LA, Abell CE, Millman ST, et al. Kinematics as objective tools to evaluate lameness phases in multiparous sows. Livest Sci. 2014;165:120 8. h t t p s

chunk 51 · 448 tokens

LA, Abell CE, Millman ST, et al. Kinematics as objective tools to evaluate lameness phases in multiparous sows. Livest Sci. 2014;165:120 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 4 . 0 4 . 0 3 1 . 34. Karriker LA, Abell CE, Pairis-Garcia MD, Holt WA, Sun G, Coetzee JF, et al. Validation of a lameness model in sows using physiological and mechanical measurements. J Anim Sci. 2013;91(1):130 6. h t t p s : / / d o i . o r g / 1 0 . 2 5 2 7 / j a s . 2 0 1 1 - 4 9 9 4 . 35. Meyer D, Hewicker-Trautwein M, Hartmann M, Kreienbrock L, Grosse Beilage E. Scoring shoulder ulcers in breeding sows - is a distinction between sub - stantial and insubstantial animal welfare-related lesions possible on clinical examination? Porc Health Manag. 2019;5:3. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 4 0 8 1 3 - 0 1 8 - 0 1 0 8 - 3 . 36. Hargis AM, Ginn PE. The integument. In Zachary JF, McGavin MD, editors. athologic Basis of Veterinary Disease. Missouri 2012. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / B 9 7 8 - 0 - 3 2 3 - 3 5 7 7 5 - 3 . 0 0 0 1 7 - 5 37. Jensen HE, Dahl-Pedersen K, Barington K, Kaiser M, Bonde MK, Herskin MS, et al. Grading of shoulder ulcerations in sows by biopsies. J Vet Diagn Invest. 2014;26(2):291 6. h t t p s : / / d o i . o r g / 1 0 . 1 1 7 7 / 1 0 4 0 6 3 8 7 1 3 5 2 0 5 4 0 . 38. Barington K, Dich-Jorgensen K, Jensen HE. A retrospective study of forensic cases of skin ulcerations in Danish pigs from 2000 to 2014. Acta Vet Scand. 2016;58(1):48. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 1 3 0 2 8 - 0 1 6 - 0 2 2 9 - 0 . 39. Rioja-Lang FC, Seddon YM, Brown JA. Shoulder lesions in sows: a review of their causes, prevention, and treatment. J Swine Health Prod. 2018;26(2):101 7. 40. Jensen HE. Investigation

chunk 52 · 447 tokens

JA. Shoulder lesions in sows: a review of their causes, prevention, and treatment. J Swine Health Prod. 2018;26(2):101 7. 40. Jensen HE. Investigation into the pathology of shoulder ulcerations in sows. Vet Rec. 2009;165(6):171 4. 41. Lowthian PT. Trauma and thrombosis in the pathogenesis of pressure ulcers. Clin Dermatol. 2005;23(1):116 23. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . c l i n d e r m a t o l . 2 0 0 4 . 1 0 . 0 0 1 . 42. Schmoll F, Sipos W, Kahlbacher H, Schilcher F, Bagó Z, Bunka S, et al. Clinical and pathological features of the Porcine Ulcerative Dermatitis Syndrome (PUDS). J Vet Med Physiol Pathol Clin Med. 2004;51(1):15 8. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / j . 1 4 3 9 - 0 4 4 2 . 2 0 0 4 . 0 0 5 9 7 . x . 43. Zeeh F, Suter MM, Mueller E, Brünisholz N, Zimmerman W, Ricklin M, et al. Chronological clinical and pathological documentation of porcine ulcerative dermatitis. Veterinary Dermatol. 2016;27(4):315 e78. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / v d e . 1 2 3 2 4 . 44. Meyer D, Vogel C, Kreienbrock L, große Beilage E. How e ective are clinical pre-farrowing risk assessment and the use of soft rubber mats in preventing shoulder ulcers in at-risk sows? Porc Health Manag. 2019;5(1):16. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 4 0 8 1 3 - 0 1 9 - 0 1 2 3 - z . 45. Herskin MS, Bonde MK, Jørgensen E, Jensen KH. Decubital shoulder ulcers in sows: a review of classi cation, pain and welfare consequences. Animal. 2011;5(5):757 66. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 0 0 0 2 0 3 X . 46. Staveley LM, Zemitis JE, Plush KJ, Souza DN. Infrared thermography for early identi cation and treatment of shoulder sores to improve sow and Piglet Welfare. Anim (Basel). 2022;12(22):3136. h

chunk 53 · 285 tokens

DN. Infrared thermography for early identi cation and treatment of shoulder sores to improve sow and Piglet Welfare. Anim (Basel). 2022;12(22):3136. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / a n i 1 2 2 2 3 1 3 6 . 47. Gaab T, Nogay E, Pierdon M. Development and progression of shoulder lesions and their in uence on sow Behavior. Animals. 2022;12(3):224. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / a n i 1 2 0 3 0 2 2 4 . 48. Nystén M, Orro T, Peltoniemi O. Systemic in ammatory response to shoulder ulcers and lack of preventive e ect of postpartum pain medication with ketoprofen in sows. Livest Sci. 2018;214:9 17. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 8 . 0 4 . 0 1 9 . 49. Kaiser M, Kristensen CS, Bækbo P, Alban L. Treatment of shoulder ulcers in sows rubber mats and zinc ointment compared to chlortetracycline spray. Acta Vet Scand. 2013;55(1):12. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 1 7 5 1 - 0 1 4 7 - 5 5 - 1 2 . 50. Carr DB, Goudas LC. Acute pain. Lancet. 1999;353(9169):2051 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / S 0 1 4 0 - 6 7 3 6 ( 9 9 ) 0 3 3 1 3 - 9 .

chunk 54 · 446 tokens

Page 14 of 17 51. Dahl-Pedersen K, Bonde MK, Herskin MS, Jensen KH, Kaiser M, Jensen HE. Pathogenesis and pathology of shoulder ulcerations in sows with special reference to peripheral nerves and behavioural responses to palpation. Vet J. 2013;198(3):666 71. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 1 3 . 0 9 . 0 5 9 . 52. Günes UY. A descriptive study of pressure ulcer pain. Ostomy Wound Man - age. 2008;54(2):56 61. 53. Spilsbury K, Nelson A, Cullum N, Iglesias C, Nixon J, Mason S. Pressure ulcers and their treatment and e ects on quality of life: hospital inpatient perspec - tives. J Adv Nurs. 2007;57(5):494 504. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / j . 1 3 6 5 - 2 6 4 8 . 2 0 0 6 . 0 4 1 4 0 . x . 54. Larsen T, Kaiser M, Herskin MS. Does the presence of shoulder ulcers a ect the behaviour of sows? Res Vet Sci. 2015;98:19 24. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . r v s c . 2 0 1 4 . 1 1 . 0 0 1 . 55. Jensen HE, Bonde MK, Bådsgaard NP, Dahl-Pedersen K, Andersen PH, Herskin MS, et al. En Enkel Og valideret skala for klinisk vurdering af skuldersår. Dansk Veterinaertidsskrift. 2011;6(9):6 12. 56. Woolf CJ, Chong MS. Preemptive analgesia treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg. 1993;77(2):362 79. h t t p s : / / d o i . o r g / 1 0 . 1 2 1 3 / 0 0 0 0 0 5 3 9 - 1 9 9 3 7 7 0 2 0 - 0 0 0 2 6 . 57. Simonsen HB, Klinken L, Bindseil E. Histopathology of intact and docked pigtails. Br Vet J. 1991;147(5):407 12. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / 0 0 0 7 - 1 9 3 5 ( 9 1 ) 9 0 0 8 2 - X . 58. Vinuela-Fernandez I, Jones E, Welsh EM, Fleetwood-Walker SM. Pain mechanisms and their implication for the management of pain in farm and companion animals.

chunk 55 · 443 tokens

a-Fernandez I, Jones E, Welsh EM, Fleetwood-Walker SM. Pain mechanisms and their implication for the management of pain in farm and companion animals. Vet J. 2007;174(2):227 39. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 0 7 . 0 2 . 0 0 2 . 59. Reese D, Straw BE, Waddell JM. Shoulder ulcers in sows. Neb Swine Rep. 2005:34. 60. Westin R, Rydberg A, editors. Thermal imaging for early detection of shoulder lesion development in sows. International Conference on Agricultural Engineering-AgEng; 2010; 1 8. 61. grosse Beilage E. Schulterulkus Bei Sauen - Ein unterschätztes Tierschutzprob - lem. Praktische Tierarzt. 2015;96:291 8. 62. Herskin MS, Di Giminiani P. 11 - Pain in pigs: Characterisation, mechanisms and indicators. In: pinka M, editor. Advances in Pig Welfare. Woodhead Publishing; 2018. pp. 325 55. 63. Rosendal T, Nielsen JP. Risk factors for the development of decubital ulcers over the scapula in sows. Hamburg, Germany: IPVS; 2004. 64. Bonde M, Rousing T, Badsberg JH, Sørensen JT. Associations between lying-down behaviour problems and body condition, limb disorders and skin lesions of lactating sows housed in farrowing crates in commercial sow herds. Livest Prod Sci. 2004;87(2):179 87. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v p r o d s c i . 2 0 0 3 . 0 8 . 0 0 5 . 65. Davies PR, Morrow WEM, Miller DC, Deen J. Epidemiologic study of decubital ulcers in sows. J Am Vet Med Assoc. 1996;208:1058 62. 66. Atkinson M, Amezcua R, DeLay J, Widowski T, Friendship R. Evaluation of the e ect of umbilical hernias on play behaviors in growing pigs. Can Vet J. 2017;58(10):1065 72. 67. Martín-Alguacil N, Avedillo L. Body wall defects: Gastroschisis and omphalo - coele in pigs (Sus scrofa domesticus). J Comp Pathol.

chunk 56 · 447 tokens

8(10):1065 72. 67. Martín-Alguacil N, Avedillo L. Body wall defects: Gastroschisis and omphalo - coele in pigs (Sus scrofa domesticus). J Comp Pathol. 2020;175:69 74. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . j c p a . 2 0 1 9 . 1 2 . 0 0 3 . thieme. 68. Klop eisch R, Gruber AD. Verdauungsorgane. In: Baumgärtner W, Gruber A, editors. Spezielle Pathologie für die Tiermedizin. 2. Stuttgart: Thieme; 2020. h t t p s : / / d o i . o r g / 1 0 . 1 0 5 5 / b - 0 0 4 0 - 1 7 7 6 0 6 . 69. Souza MR, Ibelli AMG, Savoldi IR, Cantão ME, Peixoto JO, Mores MAZ, et al. Transcriptome analysis identi es genes involved with the development of umbilical hernias in pigs. PLoS ONE. 2020;15(5):e0232542. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 2 3 2 5 4 2 . 70. Schild S-LA, Rousing T, Jensen HE, Barington K, Herskin MS. Do umbilical outpouchings a ect the behaviour or clinical condition of pigs during 6 h housing in a pre-transport pick-up facility? Res Vet Sci. 2015;101:126 31. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . r v s c . 2 0 1 5 . 0 6 . 0 0 5 . 71. Hovmand-Hansen T, Nielsen SS, Jensen TB, Vestergaard K, Nielsen MBF, Jensen HE. Survival of pigs with di erent characteristics of umbilical outpouching in a prospective cohort study of Danish pigs. Prev Vet Med. 2021;191:105343. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . p r e v e t m e d . 2 0 2 1 . 1 0 5 3 4 3 . 72. Hovmand-Hansen T, Jensen TB, Vestergaard K, Nielsen MBF, Leifsson PS, Jensen HE. Early risk factors, development, disappearance and contents of umbilical outpouching in Danish pigs. Livest Sci. 2021;251:104654. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 2 1 . 1 0 4 6 5 4 . 73. Straw B, Bates R, May G. Anatomical abnormalities

chunk 57 · 447 tokens

04654. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 2 1 . 1 0 4 6 5 4 . 73. Straw B, Bates R, May G. Anatomical abnormalities in a group of nishing pigs: prevalence and pig performance. J Swine Health Prod. 2009;17:28 31. 74. Velasco M, Garcia-Ureña MA, Hidalgo M, Vega V, Carnero FJ. Current concepts on adult umbilical hernia. Hernia. 1999;3(4):233 9. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 7 / B F 0 1 1 9 4 4 3 7 . 75. Kumar V, Gangwar AK, Kumar N, Singh H. Use of the bubaline acellular diaphragm matrix for umbilical hernioplasty in pigs. Veterinarski Arhiv. 2015;85(1):49 58. 76. Spadola F, Neve VC, Interlandi CD, Spadaro A, Macrì F, Iannelli NM, et al. Her - nioplasty with peritoneal ap for the Surgical treatment of umbilical hernia in Swine. Anim (Basel). 2022;12(23):3240. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / a n i 1 2 2 3 3 2 4 0 . 77. Vogels RRM, Kaufmann R, van den Hil LCL, van Steensel S, Schreinemacher MHF, Lange JF, et al. Critical overview of all available animal models for abdominal wall hernia research. Hernia. 2017;21(5):667 75. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 7 / s 1 0 0 2 9 - 0 1 7 - 1 6 0 5 - z . 78. Taylor NR, Main DC, Mendl M, Edwards SA. Tail-biting: a new perspective. Vet J. 2010;186(2):137 47. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 0 9 . 0 8 . 0 2 8 . 79. Boyle LA, Edwards SA, Bolhuis JE, Pol F, emrov MZ, Schütze S, et al. The evidence for a Causal Link between Disease and Damaging Behavior in pigs. Front Vet Sci. 2022;8:771682. h t t p s : / / d o i . o r g / 1 0 . 3 3 8 9 / f v e t s . 2 0 2 1 . 7 7 1 6 8 2 . 80. Valros A, Heinonen M. Save the pig tail. Porc Health Manag. 2015;1:2. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 2 0 5 5 - 5 6 6 0 - 1 - 2 .

chunk 58 · 447 tokens

80. Valros A, Heinonen M. Save the pig tail. Porc Health Manag. 2015;1:2. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 2 0 5 5 - 5 6 6 0 - 1 - 2 . 81. Valros A, Lopez-Martinez MJ, Munsterhjelm C, Lopez-Arjona M, Ceron JJ. Novel saliva biomarkers for stress and infection in pigs: changes in oxytocin and procalcitonin in pigs with tail-biting lesions. Res Vet Sci. 2022;153:49 56. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . r v s c . 2 0 2 2 . 1 0 . 0 1 3 . 82. Henry M, Jansen H, Amezcua MDR, O Sullivan TL, Niel L, Shoveller AK, et al. Tail-biting in pigs: a scoping review. Anim (Basel). 2021;11(7). h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / a n i 1 1 0 7 2 0 0 2 . 83. V A. Review: the tale of the Finnish pig tail how to manage non-docked pigs? Animal. 2022;16:100353. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . A n i m a l . 2 0 2 1 . 1 0 0 3 5 3 . 84. Munsterhjelm C, Brunberg E, Heinonen M, Keeling L, Valros A. Stress mea - sures in tail biters and bitten pigs in a matched case-control study. Anim Welf. 2013;22(3):331 8. h t t p s : / / d o i . o r g / 1 0 . 7 1 2 0 / 0 9 6 2 7 2 8 6 . 2 2 . 3 . 3 3 1 . 85. Bolhuis JE, Schouten WGP, Schrama JW, Wiegant VM. Behavioural develop - ment of pigs with di erent coping characteristics in barren and substrate- enriched housing conditions. Appl Anim Behav Sci. 2005;93(3):213 28. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 0 5 . 0 1 . 0 0 6 . 86. Wallgren T, Larsen A, Gunnarsson S. Tail posture as an Indicator of tail biting in Undocked Finishing pigs. Animals. 2019;9(1):18. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / a n i 9 0 1 0 0 1 8 . 87. Madey-Rindermann D. Ohrbeißen Beim Schwein Ursachen, Dynamik Und Lösungsansätze. veterinär Spiegel. 2018;28(02):66 72.

chunk 59 · 446 tokens

0 / a n i 9 0 1 0 0 1 8 . 87. Madey-Rindermann D. Ohrbeißen Beim Schwein Ursachen, Dynamik Und Lösungsansätze. veterinär Spiegel. 2018;28(02):66 72. 88. Schrøder-Petersen D, Simonsen H. Tail biting in pigs. Vet J. 2001;162(3):196 210. h t t p s : / / d o i . o r g / 1 0 . 1 0 5 3 / t v j l . 2 0 0 1 . 0 6 0 5 . 89. Valros A. Chapter 5 - tail biting. In: pinka M, editor. Advances in Pig Welfare. Woodhead Publishing; 2018. pp. 137 66. 90. Bracke MBM, De Lauwere CC, Wind SMM, Zonerland JJ. Attitudes of Dutch Pig farmers towards tail biting and tail docking. J Agric Environ Ethics. 2013;26(4):847 68. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 7 / s 1 0 8 0 6 - 0 1 2 - 9 4 1 0 - 2 . 91. Brunberg E, Wallenbeck A, Keeling LJ. Tail biting in fattening pigs: associations between frequency of tail biting and other abnormal behaviours. Appl Anim Behav Sci. 2011;133(1):18 25. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 1 . 0 4 . 0 1 9 . 92. Sandercock DA, Smith SH, Di Giminiani P, Edwards SA. Histopathological characterization of tail injury and traumatic neuroma development after tail docking in piglets. J Comp Pathol. 2016;155(1):40 9. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . j c p a . 2 0 1 6 . 0 5 . 0 0 3 . 93. Sandercock DA, Barnett MW, Coe JE, Downing AC, Nirmal AJ, Di Giminiani P, et al. Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in tail amputated pigs shows Long-Term e ects on many Pain-Associated genes. Front Vet Sci. 2019;6:314. h t t p s : / / d o i . o r g / 1 0 . 3 3 8 9 / f v e t s . 2 0 1 9 . 0 0 3 1 4 . 94. Sandercock D, Smith S, Di Giminiani P, Edwards S. Corrigendum to Histopath - ological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets

chunk 60 · 252 tokens

iani P, Edwards S. Corrigendum to Histopath - ological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets (J Comp Pathol 155 (1)(2016) 40 49). J Comp Pathol. 2016;155(2 3):276. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . j c p a . 2 0 1 6 . 0 8 . 0 0 2 95. Beggs I. Pictorial review: imaging of peripheral nerve tumours. Clin Radiol. 1997;52(1):8 17. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / s 0 0 0 9 - 9 2 6 0 ( 9 7 ) 8 0 2 9 9 - 1 . 96. Munsterhjelm C, Simola O, Keeling L, Valros A, Heinonen M. Health parameters in tail biters and bitten pigs in a case control study. Animal. 2013;7(5):814 21. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 2 0 0 2 1 9 4 . 97. Lahrmann HP, Hansen CF, D Eath R, Busch ME, Forkman B. Tail posture pre - dicts tail biting outbreaks at pen level in weaner pigs. Appl Anim Behav Sci. 2018;200:29 35. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 7 . 1 2 . 0 0 6 .

chunk 61 · 447 tokens

Page 15 of 17 98. Larsen ML, Andersen HM, Pedersen LJ. Can tail damage outbreaks in the pig be predicted by behavioural change? Vet J. 2016;209:50 6. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 1 5 . 1 2 . 0 0 1 . 99. D Eath RB, Foister S, Jack M, Bowers N, Zhu Q, Barclay D, et al. Changes in tail posture detected by a 3D machine vision system are associated with injury from damaging behaviours and ill health on commercial pig farms. PLoS ONE. 2021;16(10):e0258895. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 2 5 8 8 9 5 . 100. Larsen MLV, Andersen HM-L, Pedersen LJ. Tail posture as a detector of tail damage and an early detector of tail biting in nishing pigs. Appl Anim Behav Sci. 2018;209:30 5. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 8 . 0 8 . 0 1 6 . 101. Viitasaari E, Raekallio M, Valros A, Peltoniemi O, Hänninen L, Heinonen M. The e ect of ketoprofen on feeding behavior of tail-bitten pigs. Porc Health Manag. 2015;1:1 7. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 4 0 8 1 3 - 0 1 5 - 0 0 0 5 - y . 102. Munsterhjelm C, Heinonen M, Valros A. E ects of clinical lameness and tail biting lesions on voluntary feed intake in growing pigs. Livest Sci. 2015;181:210 9. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 5 . 0 9 . 0 0 3 . 103. Heinonen M, Orro T, Kokkonen T, Munsterhjelm C, Peltoniemi O, Valros A. Tail biting induces a strong acute phase response and tail-end in ammation in nishing pigs. Vet J. 2010;184(3):303 7. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 0 9 . 0 2 . 0 2 1 . 104. Carroll GA, Boyle LA, Hanlon A, Palmer MA, Collins L, Gri n K, et al. Identifying physiological measures of lifetime welfare status in

chunk 62 · 447 tokens

. 0 2 1 . 104. Carroll GA, Boyle LA, Hanlon A, Palmer MA, Collins L, Gri n K, et al. Identifying physiological measures of lifetime welfare status in pigs: exploring the useful - ness of haptoglobin, C- reactive protein and hair cortisol sampled at the time of slaughter. Ir Vet J. 2018;71(1):8. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 1 3 6 2 0 - 0 1 8 - 0 1 1 8 - 0 . 105. Keeling LJ, Wallenbeck A, Larsen A, Holmgren N. Scoring tail damage in pigs: an evaluation based on recordings at Swedish slaughterhouses. Acta Vet Scand. 2012;54(1):1 6. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 1 7 5 1 - 0 1 4 7 - 5 4 - 3 2 . 106. Zonderland JJ, Wolthuis-Fillerup M, Van Reenen CG, Bracke MB, Kemp B, Den Hartog LA, et al. Prevention and treatment of tail biting in weaned piglets. Appl Anim Behav Sci. 2008;110(3 4):269 81. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 0 7 . 0 4 . 0 0 5 . 107. Abriel M. Untersuchungen zum Schwanzbeißen in der Ferkelaufzucht. Dis - sertation, Technische Universität München; 2017. h t t p s : / / m e d i a t u m . u b . t u m . d e / ? i d = 1 4 2 9 7 8 5 108. Schrøder-Petersen D, Heiskanen T, Ersbøll A. Tail-in-mouth behaviour in slaughter pigs, in relation to internal factors such as: age, size, gender, and motivational background. Acta Agriculturae Scand Sect A-Animal Sci. 2004;54(3):159 66. h t t p s : / / d o i . o r g / 1 0 . 1 0 8 0 / 0 9 0 6 4 7 0 0 4 1 0 0 0 3 8 3 5 . 109. vom Brocke AL, Karnholz C, Madey-Rindermann D, Gauly M, Leeb C, Winckler C, et al. Tail lesions in fattening pigs: relationships with postmortem meat inspection and in uence of a tail biting management tool. Animal. 2019;13(4):835 44. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 8 0 0 2 0 7 0 . 110.

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of a tail biting management tool. Animal. 2019;13(4):835 44. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 8 0 0 2 0 7 0 . 110. Ursinus WW, Van Reenen CG, Kemp B, Bolhuis JE. Tail biting behaviour and tail damage in pigs and the relationship with general behaviour: Predicting the inevitable? Appl Anim Behav Sci. 2014;156:22 36. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 4 . 0 4 . 0 0 1 . 111. D Eath RB, Jack M, Futro A, Talbot D, Zhu Q, Barclay D, et al. Automatic early warning of tail biting in pigs: 3D cameras can detect lowered tail posture before an outbreak. PLoS ONE. 2018;13(4):e0194524. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 1 9 4 5 2 4 . 112. Lahrmann H, Busch M, D eath R, Forkman B, Hansen C. More tail lesions among undocked than tail docked pigs in a conventional herd. Animal. 2017;11(10):1825 31. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 7 5 1 7 3 1 1 1 7 0 0 0 4 9 0 . 113. große Beilage E, Wendt M. Diagnostik Und Gesundheitsmanagement Im Schweinebestand. Stuttgart: Ulmer; 2013. 114. Bracke M, Ettema K. Pigs su ering from injurious behaviours like ank biting and tail biting are more interested to manipulate a novel rope than uninjured control In EdsBroek, L.W.S. Loijens, M. Woloszynowska-Fraser, and L.P.J.J. Noldus: Proceedings of Measuring Behavior. A.J. Spink, E.L. van den 2014, Wageningen, The Netherlands, August 27 29, 2014. P.280-4. 115. Diana A, Carpentier L, Piette D, Boyle LA, Berckmans D, Norton T. An etho - gram of biter and bitten pigs during an ear biting event: rst step in the development of a Precision Livestock Farming tool. Appl Anim Behav Sci. 2019;215:26 36. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0

chunk 64 · 446 tokens

of a Precision Livestock Farming tool. Appl Anim Behav Sci. 2019;215:26 36. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 9 . 0 3 . 0 1 1 . 116. Mirt D. Lesions of so-called ank biting and necrotic ear syndrome in pigs. Vet Rec. 1999;144(4):92 6. h t t p s : / / d o i . o r g / 1 0 . 1 1 3 6 / v r . 1 4 4 . 4 . 9 2 . 117. Malik M, Chiers K, Boyen F, Croubels S, Maes D. Porcine ear necrosis. Vet J. 2021;271:105655. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . t v j l . 2 0 2 1 . 1 0 5 6 5 5 . 118. Richardson J, Morter R, Rebar A, Olander H. Lesions of porcine necrotic ear syndrome. Vet Pathol. 1984;21(2):152 7. h t t p s : / / d o i . o r g / 1 0 . 1 1 7 7 / 0 3 0 0 9 8 5 8 8 4 0 2 1 0 0 2 0 3 . 119. Leslie E, Hernández-Jover M, Newman R, Holyoake P. Assessment of acute pain experienced by piglets from ear tagging, ear notching and intraperito - neal injectable transponders. Appl Anim Behav Sci. 2010;127(3 4):86 95. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 0 . 0 9 . 0 0 6 . 120. Van Putten G, Van de Burgwal J. Vulva biting in group-housed sows: prelimi - nary report. Appl Anim Behav Sci. 1990;26(1 2):181 6. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / 0 1 6 8 - 1 5 9 1 ( 9 0 ) 9 0 0 9 7 - W . 121. Hodgkiss N, Eddison J, Brooks P, Bugg P. Assessment of the injuries sustained by pregnant sows housed in groups using electronic feeders. Vet Rec. 1998;143(22):604 7. h t t p s : / / d o i . o r g / 1 0 . 1 1 3 6 / v r . 1 4 3 . 2 2 . 6 0 4 . 122. Muirhead MR, Alexander TJ. Managing pig health and the treatment of disease: A reference for the farm: 5 M Enterprises Ltd., PO Box 233.; 1997. 123. Olsson A-C, Andersson M, Botermans J, Rantzer D, Svendsen J. Animal interaction and response to

chunk 65 · 447 tokens

he farm: 5 M Enterprises Ltd., PO Box 233.; 1997. 123. Olsson A-C, Andersson M, Botermans J, Rantzer D, Svendsen J. Animal interaction and response to electronic sow feeding (ESF) in 3 di erent herds and e ects of function settings to increase capacity. Livest Sci. 2011;137(1 3):268 72. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . l i v s c i . 2 0 1 0 . 1 0 . 0 1 4 . 124. Andersen IL, Bøe KE, Kristiansen AL. The in uence of di erent feeding arrangements and food type on competition at feeding in pregnant sows. Appl Anim Behav Sci. 1999;65(2):91 104. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / S 0 1 6 8 - 1 5 9 1 ( 9 9 ) 0 0 0 5 8 - 1 . 125. Jarvis S, McLean KA, Chirnside J, Deans LA, Calvert SK, Molony V, et al. Opioid- mediated changes in nociceptive threshold during pregnancy and parturi - tion in the sow. Pain. 1997;72(1 2):153 9. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / s 0 3 0 4 - 3 9 5 9 ( 9 7 ) 0 0 0 2 7 - 4 . 126. Mainau E, Manteca X. Pain and discomfort caused by parturition in cows and sows. Appl Anim Behav Sci. 2011;135(3):241 51. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 1 1 . 1 0 . 0 2 0 . 127. Bracke M. 9. Vulva biting. In: Velarde A, Geers R, editors. On farm monitoring of Pig Welfare. Netherlands: Wageningen Academic; 2007. pp. 65 9. h t t p s : / / d o i . o r g / 1 0 . 3 9 2 0 / 9 7 8 9 0 8 6 8 6 5 9 1 8 _ 0 1 0 . 128. Brown SA. Vulva biting in sows housed in electronic sow feeders (ESF) and spin fed yards. UK Vet Livest. 2008;13(3):55 8. 129. Liedel C, Mayer L, Einspanier A, Völker I, Ulrich R, Rieckmann K, et al. A new S. suis serotype 3 infection model in pigs: lack of e ect of buprenorphine treat - ment to reduce distress. BMC Vet Res. 2022;18(1):435. h t t p s : / / d o i . o r g / 1 0

chunk 66 · 445 tokens

ection model in pigs: lack of e ect of buprenorphine treat - ment to reduce distress. BMC Vet Res. 2022;18(1):435. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / s 1 2 9 1 7 - 0 2 2 - 0 3 5 3 2 - w . 130. Gottschalk M, Xu J, Calzas C, Segura M. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol. 2010;5(3):371 91. h t t p s : / / d o i . o r g / 1 0 . 2 2 1 7 / f m b . 1 0 . 2 . 131. Gottschalk M, Segura M. Streptococcosis. In: Zimmermann JJ, Karriker, LA, Ramirez, A., Schwartz, K.J., Stevenson, GW, Zhang, J, editors. In: Diseases of Swine, ed.11th, pp. 934 50. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 2 / 9 7 8 1 1 1 9 3 5 0 9 2 7 . c h 6 1 132. Sanford SE, Tilker ME. Streptococcus suis type II-associated diseases in swine: observations of a one-year study. J Am Vet Med Assoc. 1982;181(7):673 6. 133. Amass SF, SanMiguel P, Clark LK. Demonstration of vertical transmission of Streptococcus suis in swine by genomic ngerprinting. J Clin Microbiol. 1997;35(6):1595 6. h t t p s : / / d o i . o r g / 1 0 . 1 1 2 8 / j c m . 3 5 . 6 . 1 5 9 5 - 1 5 9 6 . 1 9 9 7 . 134. Wertheim HF, Nghia HD, Taylor W, Schultsz C. Streptococcus suis: an emerg - ing human pathogen. Clin Infect Dis. 2009;48(5):617 25. h t t p s : / / d o i . o r g / 1 0 . 1 0 8 6 / 5 9 6 7 6 3 . 135. van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D. Strep - tococcus suis Meningitis: a systematic review and Meta-analysis. PLoS Negl Trop Dis. 2015;9(10):e0004191. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p n t d . 0 0 0 4 1 9 1 . 136. Bui HT, Hoang VH, Ngo TV, Bui HV. Etiology and clinical features of bacte - rial meningitis in adults at National Hospital for Tropical Diseases during 2015 2018. Jpn J Infect Dis.

chunk 67 · 334 tokens

HV. Etiology and clinical features of bacte - rial meningitis in adults at National Hospital for Tropical Diseases during 2015 2018. Jpn J Infect Dis. 2023;76(2):101 5. h t t p s : / / d o i . o r g / 1 0 . 7 8 8 3 / y o k e n . J J I D . 2 0 2 1 . 7 8 9 . 137. Ruggeri M, Paitan Y, Chai O, Ruggeri M. Dvm. Streptococcus suis spinal men - ingitis in a cat case report: spinal Meningitis Associated with Streptococcus suis infection in a cat. Isr J Veterinary Med. 2019;74:155 60. 138. Laval A, Tessier P, Descamps D, Dréau D, Fleury R, le Coz P, et al. Use of anti- in ammatory drugs in the pig. Bull Des GTV. 2014;76:69 76. h t t p s : / / d o i . o r g / 1 0 . 5 5 5 5 / 2 0 1 5 3 1 0 9 7 6 6 . 139. Yaeger MJ, Van Alstine WG. Respiratory System. In: Zimmermann JJ, Karriker, LA, Ramirez, A., Schwartz, K.J., Stevenson, GW, Zhang, J, editors. In: Diseases of Swine, ed.11th, pp. 393 407. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 2 / 9 7 8 1 1 1 9 3 5 0 9 2 7 . c h 2 1 140. Pessoa J, Rodrigues da Costa M, García Manzanilla E, Norton T, McAloon C, Boyle L. Managing respiratory disease in nisher pigs: combining quantitative assessments of clinical signs and the prevalence of lung lesions at slaughter. Prev Vet Med. 2021;186:105208. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . p r e v e t m e d . 2 0 2 0 . 1 0 5 2 0 8 .

chunk 68 · 447 tokens

Page 16 of 17 141. Soutter F, Priestnall SL, Catchpole B, Rycroft AN. An experimental dermal Oedema Model for Apx toxins of Actinobacillus pleuropneumoniae. J Comp Pathol. 2022;195:12 8. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . j c p a . 2 0 2 2 . 0 4 . 0 0 4 . 142. Swinkels JM, Pijpers A, Vernooy JCM, Nes Av, Verheijden JHM. E ects of ketoprofen and unixin in pigs experimentally infected with Actinobacillus pleuropneumoniae. J Vet Pharmacol Ther. 1994;17(4):299 303. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / j . 1 3 6 5 - 2 8 8 5 . 1 9 9 4 . t b 0 0 2 4 9 . x . 143. Wang Q, Wang M, Liu C, Huang L, Gao Y, Yu M, et al. Ammonia exposure induced cilia dysfunction of nasal mucosa in the piglets. BioMed Res Int. 2020;1705387. h t t p s : / / d o i . o r g / 1 0 . 1 1 5 5 / 2 0 2 0 / 1 7 0 5 3 8 7 . 144. Jones JB, Burgess LR, Webster AJF, Wathes CM. Behavioural responses of pigs to atmospheric ammonia in a chronic choice test. Anim Sci. 1996;63(3):437 45. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 1 3 5 7 7 2 9 8 0 0 0 1 5 3 3 2 . 145. Rytel L, Calka J. Acetylsalicylic acid-induced changes in the chemical coding of extrinsic sensory neurons supplying the prepyloric area of the porcine stomach. Neurosci Lett. 2016;617:218 24. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . n e u l e t . 2 0 1 6 . 0 2 . 0 2 9 . 146. Guevara RD, Pastor JJ, Manteca X, Tedo G, Llonch P. Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs. PLoS ONE. 2022;17(5):e0266524. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 2 6 6 5 2 4 . 147. Contreras-Aguilar MD, Escribano D, Martínez-Miró S, López-Arjona M, Rubio CP, Martínez-Subiela S, et al. Application of a score for evaluation of

chunk 69 · 445 tokens

147. Contreras-Aguilar MD, Escribano D, Martínez-Miró S, López-Arjona M, Rubio CP, Martínez-Subiela S, et al. Application of a score for evaluation of pain, distress and discomfort in pigs with lameness and prolapses: correlation with saliva biomarkers and severity of the disease. Res Vet Sci. 2019;126:155 63. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . r v s c . 2 0 1 9 . 0 8 . 0 0 4 . 148. Taylor AA, Weary DM. Vocal responses of piglets to castration: identifying procedural sources of pain. Appl Anim Behav Sci. 2000;70(1):17 26. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / s 0 1 6 8 - 1 5 9 1 ( 0 0 ) 0 0 1 4 3 - x . 149. Morton DB, Gri ths P. Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet Rec. 1985;116(16):431 6. h t t p s : / / d o i . o r g / 1 0 . 1 1 3 6 / v r . 1 1 6 . 1 6 . 4 3 1 . 150. Sneddon LU, Elwood RW, Adamo SA, Leach MC. De ning and assessing animal pain. Anim Behav. 2014;97:201 12. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a n b e h a v . 2 0 1 4 . 0 9 . 0 0 7 . 151. Cybulski P, Woźniak A, Urban J, Stadejek T. Gastric lesions in culled sows: an underestimated welfare issue in modern swine production. Agriculture. 2021;11(10):927. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / a g r i c u l t u r e 1 1 1 0 0 9 2 7 . 152. Rutherford KM, Thompson CS, Thomson JR, Lawrence AB, Nielsen EO, Busch ME, et al. A study of associations between gastric ulcers and the behaviour of nisher pigs. Livest Sci. 2018;212:45 51. 0.1016/j.livsci.2018.03.013. 153. Holinger M, Früh B, Stoll P, Kreuzer M, Hilmman E, editors. Fattening pigs dis - play weak behavioural changes due to gastric ulcerations. Book of Abstracts of the 71st Annual Meeting of the European

chunk 70 · 446 tokens

, editors. Fattening pigs dis - play weak behavioural changes due to gastric ulcerations. Book of Abstracts of the 71st Annual Meeting of the European Federation of Animal Science, 1st-4th December, 2020, Virtuel Meeting; 2020. 154. Zalecki M. The in uence of antral ulcers on intramural gastric nerve projec - tions supplying the pyloric sphincter in the pig (Sus scrofa domestica) neu - ronal tracing studies. PLoS ONE. 2015;10(5):e0126958. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 1 2 6 9 5 8 . 155. Zalecki M, Juranek J, Pidsudko Z, Mogielnicka-Brzozowska M, Kaleczyc J, Franke-Radowiecka A. Inferior vagal ganglion galaninergic response to gastric ulcers. PLoS ONE. 2020;15(11):e0242746. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 2 4 2 7 4 6 . 156. Pasciak AS, Nodit L, Bourgeois AC, Paxton BE, Coan PN, Clark CT, et al. How sensitive is the upper gastrointestinal tract to 90Y radioemboliza - tion? A histologic and dosimetric analysis in a porcine model. J Nucl Med. 2016;57(12):1957 63. h t t p s : / / d o i . o r g / 1 0 . 2 9 6 7 / j n u m e d . 1 1 6 . 1 7 6 7 6 8 . 157. Ghandour B, Bhullar FA, Szvarca D, Bejjani M, Brenner T, McKee K, et al. E ective, safe and e cient porcine model of Forrest ib bleeding gastric and colonic ulcers. Indian J Gastroenterol. 2023;42(1):118 27. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 7 / s 1 2 6 6 4 - 0 2 2 - 0 1 2 9 9 - 4 . 158. Li M, Jin H, Shi C, Lyu B, Ying X, Shi Y. A novel self-assembled gel for gastric endoscopic submucosal dissection-induced ulcer: a preclinical study in a porcine model. Front Pharmacol. 2021;12:700387. h t t p s : / / d o i . o r g / 1 0 . 3 3 8 9 / f p h a r . 2 0 2 1 . 7 0 0 3 8 7 . 159. Bielefeldt K, Davis B, Binion DG. Pain and

chunk 71 · 445 tokens

l. 2021;12:700387. h t t p s : / / d o i . o r g / 1 0 . 3 3 8 9 / f p h a r . 2 0 2 1 . 7 0 0 3 8 7 . 159. Bielefeldt K, Davis B, Binion DG. Pain and in ammatory bowel disease. In amm Bowel Dis. 2009;15(5):778 88. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 2 / i b d . 2 0 8 4 8 . 160. Wang H, Felt SA, Guracar I, Taviani V, Zhou J, Sigrist RMS, et al. Anatomical Road Mapping using CT and MR Enterography for Ultrasound Molecular Imaging of small bowel in ammation in Swine. Eur Radiol. 2018;28:2068 76. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 7 / s 0 0 3 3 0 - 0 1 7 - 5 1 4 8 - 6 . 161. Mikołajczyk A, Kozłowska A, Gonkowski S. Distribution and neurochemistry of the Porcine Ileocaecal Valve projecting sensory neurons in the dorsal Root Ganglia and the in uence of Lipopolysaccharide from di erent serotypes of Salmonella spp. on the Chemical Coding of DRG Neurons in the cell cultures. Int J Mol Sci. 2018;19(9):2551. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / i j m s 1 9 0 9 2 5 5 1 . 162. Liebhold M, Wendt M, Kaup FJ, Drommer W. Clinical, and light and electron microscopical ndings in sows with cystitis. Vet Rec. 1995;137(6):141 4. h t t p s : / / d o i . o r g / 1 0 . 1 1 3 6 / v r . 1 3 7 . 6 . 1 4 1 . 163. Berner H. Untersuchungen zum Vorkommen Von Harnwegsinfektionen Beim Schwein. I. Harnwegsinfektionen Bei Muttersauen in Ferkelerzeugerb - etrieben. Tieraerztl Umsch. 1981;36:162 71. 164. Becker W, Kurtz R, von Mickwitz G. Chronische Harnwegsinfektionen Beim Schwein, diagnose und Therapie (III). Prakt Tierarzt. 1988;69:41 5. 165. Stirnimann J. Akute Harnwegsentzündung Bei Der Muttersau. Schweiz Arch Tierheilkd. 1984:597 605. 166. Stirnimann J, Tschudi PR. Beurteilung Der Nierenfunktion Bei Muttersauen mit akuter Harnwegsentzündung. Schweiz Arch

chunk 72 · 446 tokens

ch Tierheilkd. 1984:597 605. 166. Stirnimann J, Tschudi PR. Beurteilung Der Nierenfunktion Bei Muttersauen mit akuter Harnwegsentzündung. Schweiz Arch Tierheilkd. 1985;127:575 82. 167. Wendt M, Liebhold M, Kaup F, Amtsberg G, Bollwahn W. Corynebacterium suis infection in swine. 1. Clinical diagnosis with special consideration of urine studies and cystoscopy. Tierarztl Prax. 1990;18(4):353 7. 168. Carr J. Cystitis and pyelonephritis in the sow. Pig Vet J. 1991;27:122 41. 169. Wendt M, Sobestiansky J. Untersuchungen Zur Therapie Von Harnwegsinfek - tionen Bei Sauen. Dtsch Tierarztl Wochenschr. 1995;102:21 7. 170. Osther PJ, Pedersen KV, Lildal SK, Pless MS, Andreassen KH, Osther SS, et al. Pathophysiological aspects of ureterorenoscopic management of upper urinary tract calculi. Curr Opin Urol. 2016;26(1):63 9. 171. Janikiewicz P, Wasilewska B, Mazur U, Franke-Radowiecka A, Majewski M, Bossowska A. The in uence of an adrenergic antagonist guanethidine (GUA) on the distribution pattern and chemical coding of dorsal Root Ganglia (DRG) neurons supplying the porcine urinary bladder. Int J Mol Sci. 2021;22(24):13399. h t t p s : / / d o i . o r g / 1 0 . 3 3 9 0 / i j m s 2 2 2 4 1 3 3 9 9 . 172. Lala V, Leslie SW, Minter DA. Acute Cystitis. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2023. StatPearls Publishing LLC.; 2023. 173. Geerlings SE. Clinical presentations and epidemiology of urinary tract infec - tions. Microbiol Spectr. 2016;4(5). h t t p s : / / d o i . o r g / 1 0 . 1 1 2 8 / m i c r o b i o l s p e c . U T I - 0 0 0 2 - 2 0 1 2 . 174. Wagenlehner FM, Hoyme U, Kaase M, Fünfstück R, Naber KG, Schmie - mann G. Uncomplicated urinary tract infections. Dtsch Arztebl Int. 2011;108(24):415 23. 175. Giesen LG, Cousins G, Dimitrov BD,

chunk 73 · 447 tokens

R, Naber KG, Schmie - mann G. Uncomplicated urinary tract infections. Dtsch Arztebl Int. 2011;108(24):415 23. 175. Giesen LG, Cousins G, Dimitrov BD, van de Laar FA, Fahey T. Predicting acute uncomplicated urinary tract infection in women: a systematic review of the diagnostic accuracy of symptoms and signs. BMC Fam Pract. 2010;11:78. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 1 4 7 1 - 2 2 9 6 - 1 1 - 7 8 . 176. Mehta P, Leslie SW, Reddivari AKR. Dysuria. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2023. StatPearls Publishing LLC.; 2023. 177. Farmer C, Maes D, Peltoniemi O. Mammary system. In: Zimmermann JJ, Karriker, LA, Ramirez, A., Schwartz, K.J., Stevenson, GW, Zhang, J, editors. In: Diseases of Swine, ed.11th, pp. 313 338. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 2 / 9 7 8 1 1 1 9 3 5 0 9 2 7 . c h 1 8 178. Chou JY, Marchant JN, Nalon E, Huynh TTT, van de Weerd HA, Boyle LA, Ison SH. Investigating risk factors behind piglet facial and sow teat lesions through a literature review and a survey on teeth reduction. Front Vet Sci. 2022;9:909401. h t t p s : / / d o i . o r g / 1 0 . 3 3 8 9 / f v e t s . 2 0 2 2 . 9 0 9 4 0 1 . 179. Christensen R, Aalbaek B, Jensen H. Pathology of udder lesions in sows. J vet Med A Physiol Pathol. Clin Med A. 2007;54(9):491 3. h t t p s : / / d o i . o r g / 1 0 . 1 1 1 1 / j . 1 4 3 9 - 0 4 4 2 . 2 0 0 7 . 0 0 9 5 2 . x . 180. Gallois M, Le Cozler Y, Prunier A. In uence of tooth resection in piglets on welfare and performance. Prev Vet Med. 2005;69(1 2):13 23. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . p r e v e t m e d . 2 0 0 4 . 1 2 . 0 0 8 . 181. Verhovsek D, Troxler J, Baumgartner J. Peripartal behaviour and teat lesions of sows in farrowing crates and in a loose-housing system.

chunk 74 · 228 tokens

. 0 0 8 . 181. Verhovsek D, Troxler J, Baumgartner J. Peripartal behaviour and teat lesions of sows in farrowing crates and in a loose-housing system. Anim Welf. 2007;16(2):273 6. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 7 / S 0 9 6 2 7 2 8 6 0 0 0 3 1 5 0 X . 182. Kim SW, Weaver AC, Shen YB, Zhao Y. Improving e ciency of sow productiv - ity: nutrition and health. J Anim Sci Biotech. 2013;4:1 8. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 2 0 4 9 - 1 8 9 1 - 4 - 2 6 . 183. Gerjets I, Kemper N. Coliform mastitis in sows: a review. J Swine Health Prod. 2009;17(2):97 105. 184. de Boyer des Roches A, Faure M, Lussert A, Herry V, Rainard P, Durand D, et al. Behavioral and patho-physiological response as possible signs of pain in dairy cows during Escherichia coli mastitis: a pilot study. J Dairy Sci. 2017;100(10):8385 97. h t t p s : / / d o i . o r g / 1 0 . 3 1 6 8 / j d s . 2 0 1 7 - 1 2 7 9 6 .

chunk 75 · 447 tokens

Page 17 of 17 185. Leslie KE, Petersson-Wolfe CS. Assessment and Management of Pain in dairy cows with clinical Mastitis. Vet Clin North Am Food Anim Pract. 2012;28(2):289 305. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . c v f a . 2 0 1 2 . 0 4 . 0 0 2 . 186. Ju J-H, Shin J-I, Lim H-Y, Kim H-W, Seung B-J, Cho S-H, et al. Classi cation, bacteriological ndings, and analysis of sex hormone receptors and cytokine expression in mammary lesions of abattoir sows. J Vet Sci. 2019;20(2):e11. h t t p s : / / d o i . o r g / 1 0 . 4 1 4 2 / j v s . 2 0 1 9 . 2 0 . e 1 1 . 187. Ren K, Torres R. Role of interleukin-1β during pain and in ammation. Brain Res Rev. 2009;60(1):57 64. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . b r a i n r e s r e v . 2 0 0 8 . 1 2 . 0 2 0 . 188. Boyle L, Leonard F, Lynch P, Brophy P. E ect of gestation housing on behaviour and skin lesions of sows in farrowing crates. Appl Anim Behav Sci. 2002;76(2):119 34. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / S 0 1 6 8 - 1 5 9 1 ( 0 1 ) 0 0 2 1 1 - 8 . 189. Valros AE, Rundgren M, pinka M, Saloniemi H, Rydhmer L, Algers B. Nursing behaviour of sows during 5 weeks lactation and e ects on piglet growth. Appl Anim Behav Sci. 2002;76(2):93 104. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / S 0 1 6 8 - 1 5 9 1 ( 0 2 ) 0 0 0 0 6 - 0 . 190. Lewis E, Boyle L, Brophy P, O doherty J, Lynch P. The e ect of two piglet teeth resection procedures on the welfare of sows in farrowing crates. Part 2. Appl Anim Behav Sci. 2005;90(3 4):251 64. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 0 4 . 0 8 . 0 0 7 . 191. Lewis E, Boyle L, O Doherty J, Lynch P, Brophy P. The e ect of providing shredded paper or ropes to piglets in farrowing crates on their behaviour and health and

chunk 76 · 444 tokens

yle L, O Doherty J, Lynch P, Brophy P. The e ect of providing shredded paper or ropes to piglets in farrowing crates on their behaviour and health and the behaviour and health of their dams. Appl Anim Behav Sci. 2006;96(1 2):1 17. h t t p s : / / d o i . o r g / 1 0 . 1 0 1 6 / j . a p p l a n i m . 2 0 0 5 . 0 4 . 0 1 5 . 192. Kirkden R, Broom D, Andersen I. Invited review: piglet mortality: manage - ment solutions. J Anim Sci. 2013;91(7):3361 89. h t t p s : / / d o i . o r g / 1 0 . 2 5 2 7 / j a s . 2 0 1 2 - 5 6 3 7 . 193. Edwards S, Baxter E. Piglet mortality: causes and prevention. The gestating and lactating sow. Wageningen Academic; 2015. pp. 649 53. 194. Hirsch AC, Philipp H, Kleemann R. Investigation on the e cacy of meloxicam in sows with mastitis metritis agalactia syndrome. J Vet Pharmacol Ther. 2003;26(5):355 60. h t t p s : / / d o i . o r g / 1 0 . 1 0 4 6 / j . 1 3 6 5 - 2 8 8 5 . 2 0 0 3 . 0 0 5 2 4 . x . 195. Hooijmans CR, Rovers MM, de Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):43. h t t p s : / / d o i . o r g / 1 0 . 1 1 8 6 / 1 4 7 1 - 2 2 8 8 - 1 4 - 4 3 . 196. Grahofer A, Björkman S, Peltoniemi O. Diagnosis of endometritis and cystitis in sows: use of biomarkers. J Anim Sci. 2020;98(1):107 16. h t t p s : / / d o i . o r g / 1 0 . 1 0 9 3 / j a s / s k a a 1 4 4 . 197. Björkman S, Kau old J, Kaiser M. Reproductive health of the sow during puerperium. Mol Reprod Dev. 2023;90:561 79. h t t p s : / / d o i . o r g / 1 0 . 1 0 0 2 / m r d . 2 3 6 4 2 . 198. Löscher W, Richter A, Potschka H. Pharmakotherapie bei Haus- und Nutztie - ren. IN: Löscher W, Ungemach F, Kroker R. (9th Edt.). Stuttgart: Enke; 2014. 199. Jasiecka A, Maslanka T,

chunk 77 · 93 tokens

H. Pharmakotherapie bei Haus- und Nutztie - ren. IN: Löscher W, Ungemach F, Kroker R. (9th Edt.). Stuttgart: Enke; 2014. 199. Jasiecka A, Maslanka T, Jaroszewski JJ. Pharmacological characteristics of metamizole. Pol J Vet Sci. 2014;17(1). Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional a liations.