Aftovax®

(Aftovax®) was conducted in 2015 in Ngaoundere, with observations that clinical infection of FMD appeared to have been prevented, although persistent infection occurred. Cattle owners in Cameroon routinely manage the disease using…

Communication The Treatment of Contagious Ecthyma in Lambs with a Local Anaesthetic/Antiseptic Wound Formulation Lowers Serum Amyloid A Responses Aurora Ortín 1,2, * , Sergio Villanueva-Saz 1,2 , Delia Lacasta 1,2 , Peter Andrew Windsor 3 , Antonio Fernández 1 , Pablo Quilez 1,2 , Hector Ruiz 1,2 , Alex Gómez 1,2 , David Guallar 1,2 and Marta Ruiz de Arcaute 1,2 1 Animal Pathology Department, Veterinary Faculty and Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), Miguel Servet 177, 50013 Zaragoza, Spain; svs@unizar.es (S.V.-S.); dlacasta@unizar.es (D.L.); afmedica@unizar.es (A.F.); pquilez@unizar.es (P.Q.); hectorruiz353@gmail.com (H.R.); alex.gomezcalvo@gmail.com (A.G.); davidguallarabellan2002@gmail.com (D.G.); martarda@unizar.es (M.R.d.A.) 2 Ruminant Clinical Service, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain 3 Sydney School of Veterinary Science, The University of Sydney, Camden, NSW 2570, Australia; peter.windsor@sydney.edu.au * Correspondence: aortin@unizar.es; Tel.: +34-605319592 Simple Summary Contagious ecthyma (CE) is a skin disease of small ruminants with significant economic impact and welfare concerns. Vaccination is the main preventive strategy for CE, although in many countries, licenced vaccines are unavailable. Treatment typically involves an- tibiotics to control secondary infections, increasing the risk of antimicrobial resistance. The objective of this study was to evaluate the therapeutic effect of a non-antibiotic topical anaesthetic/antiseptic therapeutic formulation (Tri-Solfen® ; T-S; Medical Ethics, Australia/MultiSolfen® ; M-S; Dechra, UK) on lambs with contagious ecthyma. The con- centration of a marker of systemic inflammation, serum amyloid A (SAA), was measured during

lly sufficient to destroy virus without causing pain to the multiple models, including Herpes Simplex-1 (HSV-1) in animal. It has also been postulated that the concentration dental alginates.16 Whilst the application of acidic solu­ of lidocaine in TS is likely to be directly viricidal against tions to open wounds and ulcers is generally contraindi­ FMD virus, as at concentrations ranging from 0.5 mg/mL cated, as the acidity may exacerbate pain, the relatively (0.05%) to 100 mg/mL (10%) lidocaine blocks high concentration of lidocaine (5%) applied with bupiva­ nociception10 and has been shown to exhibit antiviral caine, adrenaline, and cetrimide in a gel matrix has been activity against the herpes virus in cell-culture and animal- Veterinary Medicine: Research and Reports 2021:12 https://doi.org/10.2147/VMRR.S306355 155 DovePress Powered by TCPDF (www.tcpdf.org) Lacasta et al Dovepress Table 5 Real-Time PCR Cq Values of Each Analysed Lamb in T0, Immediately Before Treatment, and on Days 1 (T1), 3 (T2) and 5 (T3) Post-Treatment Lamb Num. T0 T1 T2 T3 1002 28.4 30.4 33.0 30.8 Veterinary Medicine: Research and Reports downloaded from https://www.dovepress.com/ by 123.255.209.218 on 09-Jun-2021 1003 23.1 24.6 22.6 24.0 1004 29.5 27.6 31.5 32.0 1005 24.5 25.5 25.8 25.1 1007 30.4 25.9 28.4 25.9 1008 30.3 32.1 33.4 31.4 1009 34.9 35.6 Neg. 33.0 1010 31.3 32.1 31.9 31.4 1011 25.0 23.6 27.9 30.4 Figure 2 Orf viral load in T-immortalized goat fibroblasts (TIGEF) incubated with samples from naturally infected lambs obtained from control and treated groups. 1012 35.0 29.2 30.1 26.5 Data shown are the differences in viral load from T0 to T3 in control and treated 1013 29.3 27.4 27.6 33.1 animals (p> 0.05). 1015 27.0 25.7 27.4 22.9 1016 35.9 32.0 35.5 32.3 after incubation with

…A pilot trial using commercial trivalent vaccine This report describes a field trial conducted on extensive cattle (Aftovax®) was conducted in 2015 in Ngaoundere, with observations farms in Cameroon aimed at evaluating…