Aspen Pharma Trading Ltd

m (Goods and Services Tax) Act 1999 and related legislation passed by the Federal Government; "Indication" means a specific animal welfare use-case or application of the Product for which an assessment is to be performed under Schedule 2; "Insolvency Administration" means any form of external administration of the property of any person whether under the provisions of the Corporations Law, the Bankruptcy Act 1966 or any other similar legislation or otherwise including bankruptcy, winding up, liquidation, voluntary administration and the appointment of a receiver or a receiver and manager; "Intellectual Property" means all forms of intellectual property rights throughout the world including copyright, registered patent, design, trademark and confidential information including know-how and trade secrets; "Manager" means the person described in Item 5 of Schedule 1; "Moral Rights" has the meaning given to it in the Copyright Amendment (Moral Rights) Act 2000 (Cth); "Product" means Tri-Solfen, a topical anaesthetic and antiseptic wound management product manufactured by the Client; "related company" has the meaning given to a related body corporate under the Corporations Act; "rights and claims" includes all rights, entitlements, claims, debts, actions, demands, suits, proceedings, liabilities, losses, sums of money, damages, expenses and costs; "Services" includes the services described in Schedule 2 and any additional or ancillary services agreed between the Company and the Client in writing from time to time; "Term" means the period from the Commencement Date until the Termination Date unless this Deed is extended by mutual agreement by the parties in writing or this Deed is otherwise terminated; and "Termination Date" means the date set out in Item 4 of Schedule 1. 1.2

Analgesia for Surgical Husbandry Procedures in Sheep and Other Livestock Dr Meredith L Sheil, Animal Ethics Pty Ltd, Associate Sydney University Faculty of Veterinary Science SUMMARY Surgical husbandry procedures in livestock are…

…Several topical treatments with ethno-veterinary and recognized veterinary pharma- ceuticals have been examined in FMD endemic settings in Africa (Gakuya et al., 2011; Misk et al., 2015; Fakhrul-Islam et al…

-S; Dechra, UK) on lambs with contagious ecthyma. The con- centration of a marker of systemic inflammation, serum amyloid A (SAA), was measured during the clinical phase of CE in naturally and experimentally infected lambs, in cohorts either treated or not treated with the product. In the experimental infection, the treatment modified the SAA response, peaking earlier and at lower levels than in controls and show- ing significantly lower values at the completion of the experimental period than in controls. In the natural outbreak, SAA levels significantly decreased over time in the treated cohort, whereas in controls, levels remained stable at high values. These results indicate that this topical formulation reduces systemic inflammation in lambs with CE, providing supportive evidence that this is a promising non-antibiotic therapeutic alternative to current practice. Abstract Academic Editor: Clive J. C. Phillips Contagious ecthyma (CE) is a widespread, highly contagious zoonotic skin disease of Received: 10 November 2025 small ruminants caused by the Orf virus (ORFV), leading to substantial economic losses Revised: 4 December 2025 and welfare concerns. There is no specific treatment, with topical antiseptics and oral Accepted: 17 December 2025 or parenteral antibiotics often administered for preventing secondary infections, risking Published: 20 December 2025 antimicrobial resistance. This study assessed the effect of treating CE in lambs with an Copyright: © 2025 by the authors. antibiotic-free topical anaesthetic/antiseptic formulation (Tri-Solfen® ; T-S; Medical Ethics, Licensee MDPI, Basel, Switzerland. Australia/MultiSolfen® ; M-S; Dechra, UK). Serum amyloid A (SAA), a marker of systemic This article is an open access article distributed under the terms and

…eutectic mixture of local anaesthetics debridement, and inappropriate dressing selection can con- [EMLA] cream, Aspen Pharma Trading Ltd) are used, which tribute to wound-related pain.11 can take between 30 minutes…

…overdosed pento- Medical Ethics Pty Ltd) or P (Placebo, Medical Ethics barbital (Euthadorm 500 mg/mL; Injektionslösung, Pty Ltd) containing the same amount of epineph- CP Pharma) for obtaining the spinal cord…

…overdosed pento- Medical Ethics Pty Ltd) or P (Placebo, Medical Ethics barbital (Euthadorm 500 mg/mL; Injektionslösung, Pty Ltd) containing the same amount of epineph- CP Pharma) for obtaining the spinal cord…

group of LBAC on equine wounds were unknown. (α = 0.05 and β = 0.8). This study was designed as a pharmaceutical trial to compare the antinociceptive effects, measured by mechanical threshold (MT) testing, of topically Treatment applied LBAC compared with 0.9% sodium chloride on surgically created distal limb wounds in horses. The LBAC treatment contained 40.6 g/L lidocaine The influence of LBAC treatment on wound healing hydrochloride, 4.2 g/L bupivacaine hydrochloride, was a secondary aim to ensure the absence of adverse 24.8 mg/L adrenaline acid tartrate and 5.0 g/L cetrim- effects. It was hypothesised that LBAC would provide ide in a fixed combination solution that was blue in short-duration antinociception (increased MTs) with- colour. To maintain blinding to the relevant study out adversely affecting wound healing. The results personnel, the saline control solution was similarly of this study provided the evidence that led to the coloured by adding 2.5 mL of blue dye (Queen Blue LBAC formulation, marketed as Tri-Solfen, receiv- Food Colour) containing 1.8% total dyestuff to 250 mL ing registration with the Australian Therapeutic Good of 0.9% sodium chloride (Baxter Healthcare). Identi- Association as a non-prescription veterinary product cal spray bottles were used to apply 1 mL topically for use on post-traumatic equine wounds. (2 × 0.5 mL spray) of each solution directly onto the allocated wound area (1 mL per 20 mm2 ). This was sufficient to cover the entire area with minimal run MATERIALS AND METHODS off. Both solutions were stored in an insulated box in a temperature-controlled room (<25◦ C) when not in Animals use. All procedures were performed with the approval of the University of Queensland’s Production Mechanical threshold testing and Companion

…Published by Informa View supplementary material UK Limited, trading as Taylor & Francis Group Accepted author version posted online: 04 Submit your article to this journal Jul 2019. Published online: 07 Aug 2019…

…AG, Richter Pharma localWels, anesthetic Austria;agent with hydrochloride; epin.: epinephrine. AG, Melsungen, Germany; LA: local anesthetic agent with hydrochloride; epin.: epinephrine. Figure 1. Illustration of the handling chute according to Bilsborrow…