Bayer New Zealand Ltd

…an inter- The authors would like to thank Bayer New Zealand Ltd for specific study. Journal of Veterinary Pharmacology and funding the study, the farm animal owners, managers and Therapeutics 4, 87…

m (Goods and Services Tax) Act 1999 and related legislation passed by the Federal Government; "Indication" means a specific animal welfare use-case or application of the Product for which an assessment is to be performed under Schedule 2; "Insolvency Administration" means any form of external administration of the property of any person whether under the provisions of the Corporations Law, the Bankruptcy Act 1966 or any other similar legislation or otherwise including bankruptcy, winding up, liquidation, voluntary administration and the appointment of a receiver or a receiver and manager; "Intellectual Property" means all forms of intellectual property rights throughout the world including copyright, registered patent, design, trademark and confidential information including know-how and trade secrets; "Manager" means the person described in Item 5 of Schedule 1; "Moral Rights" has the meaning given to it in the Copyright Amendment (Moral Rights) Act 2000 (Cth); "Product" means Tri-Solfen, a topical anaesthetic and antiseptic wound management product manufactured by the Client; "related company" has the meaning given to a related body corporate under the Corporations Act; "rights and claims" includes all rights, entitlements, claims, debts, actions, demands, suits, proceedings, liabilities, losses, sums of money, damages, expenses and costs; "Services" includes the services described in Schedule 2 and any additional or ancillary services agreed between the Company and the Client in writing from time to time; "Term" means the period from the Commencement Date until the Termination Date unless this Deed is extended by mutual agreement by the parties in writing or this Deed is otherwise terminated; and "Termination Date" means the date set out in Item 4 of Schedule 1. 1.2

alia and New Zealand, with a demonstrated ability to reduce post-operative hyperalgesic responses and pain-related behaviour in calves post-disbudding [7,8] and castration [9]. It contains local anaesthetics (50…

and 28 They were then housed in a mixed treatment group in an indoor days later. Images were identified by lamb tag number and pen and returned to the mulesing cradle at one and 4 h after assessors were blind to treatment protocol at the time of mulesing for repeat skin and wound sensitivity testing, before performing assessments. being returned to their dams and turned out to pasture. The remaining 56 lambs were identified by a coloured number, and Weights used to assess pain-related behaviour. After mulesing lambs were Weights were recorded at time 0, and day 14 and 28 in Trial 3 randomly allocated to receive Tri-Solfen® or remain untreated using digital scales (Rudweigh®) which were calibrated and (28 lambs in each group) and Spinosyn was applied, as above. zeroed prior to each measurement and accurate to 0.1 kg. Lambs were then moved to 3 × 4 m indoor pens for quiet observation and pain-related behaviour scoring. An additional Trial protocols eight lambs served as unmulesed controls. These were placed in the cradle but remained unmulesed and unmarked. Each pen Trial 1 A placebo controlled trial (n = 60) was initiated to thus contained seven lambs, including six mulesed lambs (mixed examine skin and wound sensitivity to LT and P sensation treated and untreated) and one handled but unmulesed control 3 min and 4 h after mulesing in lambs that were undergoing lamb. Behaviour scoring was performed 5 min after return to the mulesing only. Tail docking and castration of wether lambs pen, and at 1 and 4 h. Lambs were then returned to their dams had been previously performed and wounds were fully healed. and turned out to pasture. Pain-related behaviour was measured 1, 2 and 4 hours after mulesing and wound healing was documented as outlined Trial 3 This trial examined

Analgesia for Surgical Husbandry Procedures in Sheep and Other Livestock Dr Meredith L Sheil, Animal Ethics Pty Ltd, Associate Sydney University Faculty of Veterinary Science SUMMARY Surgical husbandry procedures in livestock are…

d Bayer Animal Dehorning of cattle is painful, yet remains a commonly performed procedure in horned Health Australia had no role in study design, data collection and analysis, decision to publish, or breeds [1] as it reduces injuries from social contact, improves safety for stock-persons [2], preparation of the manuscript. Meat and Livestock dehorned cattle require less space during feeding and transport [3] and dehorning reduces Australia approves the publication of this manuscript. bruise trim at slaughter by approximately 50% [4]. As bruising of cattle costs the Australian PLOS ONE | DOI:10.1371/journal.pone.0163181 September 20, 2016 1 / 13 Topical Anaesthetic for Dehorning of Calves Competing Interests: Topical anaesthetic products beef industry approximately $30 million annually [5], retention of horns has major economic were supplied by Bayer Animal Health Australia implications. (https://www.bayer.com.au/en/about/profile-and- The northern beef industry in Australia is very extensive, with average property size organisation/animal-health/). Bayer Animal Health Australia is a commercial funder and therefore reported at 23,436 ha for 2014–2015 [6]. The majority of cattle breeds in this region are Bos potentially has competing interests. This does not Indicus or B. indicus crosses and most calves are born with horns. Animal management on alter our adherence to PLOS ONE policies on sharing these properties differs greatly from the smaller southern Australian properties and from that data and materials. of most other beef producing nations in that cattle are handled infrequently during the year. The age at which beef calves are ‘marked’ (that is, animals are mustered and subjected to hus- bandry management procedures including ear tagging, branding, vaccination

…New Zealand has legislated that from October 2019, local anaesthetic must be used prior to disbudding or dehorning cattle [18]. Farmer-applied topical local anaesthesia (TA) may address the cost, time and…

…New Zealand Veterinary Journal 44, 9–14. doi:10.1080/ anaesthetic formulation for pain management of mulesing in sheep. 00480169.1996.35924 Australian Veterinary Journal 91, 160–167. doi:10.1111/avj…

…Nonsteroidal anti-inflammatory castration (and other wounds) in lambs and calves in Australia (NSAID) medications (such as meloxicam) provide some analgesia and New Zealand. It is also reported to be effective to…