COX-2 specific NSAID

ammatory drugs (NSAIDs), such as funixin and carprofen. Although there 98 Australian Veterinary Journal Volume 85, No 3, March 2007 © 2007 The Authors Journal compilation © 2007 Australian Veterinary Association PRODUCTION ANIMALS Table 1, Experimental treatments used in the study. Group Treatment descriptor Agent(s) administered Mulesing Dose Route Time of administration relative to mulesing 1. Sham mules Normal saline (Baxter, NSW) No imL 8.c3 Oh 2, Conventional mules Normal saline (Baxter, NSW) Yes TmL 8.03 Oh 3. Topical anaesthetic Topical anaesthetic formulation Yes 8 mL/11-15kg topical Oh (Tri-Solfen, Animal Ethics, Vic): 10 mL/16-20kg 40.6 g/L lignocaine hydrochloride 4.5 g/L bupivacaine hydrochioride 24.8 mg/L adrenaline tartrate 5.0 g/L cetrimide 4, Flunixin + topical Fiunixin meglumine (Finadyne, Yes As per individual As per individual As per individual anaesthetic Schering-Plough, NSW) treatments treatments treatmenis Topical anaesthetic formulation 5. Carprofen + topical Carprofen (Rimady! injection, Yes As per individual As per individual As per individual anaesthetic Pfizer, NSW) treatments treatments treatments Topical anaesthetic formulation 6. Carprofen Carprofen Yes 4.0 mg/kg s.c2 -1.5h 7. Flunixin Fiunixin meglumine Yes 2.5 mg/kg 8.02 -1.5h 8. Carprofen + flunixin Carprofen Yes As per individual 8.0.4 -T.5h Flunixin meglumine treatments ? Subcutaneous, is relatively little published data on the use of NSAIDs in sheep, to acclimatise them to the feed rations and to close handling. both flunixin and carprofen are recommended as analgesics for Lambs were quietly handled for a 5-minute period on two sheep that are undergoing experimental surgery.!° Flunixin has occasions during the week before treatment to reduce the level been shown to be effective

…2003, hyperalgesic responses can be most specifically and Sheil et al. 2020; Sutherland et al. 2012, White et al. sensitively identified using quantitative sensory testing 1995) while NSAID treatment has little impact…

…One hundred and forty Merino lambs Non-steroidal anti-inflammatory drugs (NSAIDs) provide were allocated to one of seven treatments (n = 20 lambs per another option for mulesing analgesia. They provide long…

…Meloxicam, a COX-2 specific NSAID, is the most frequently studied NSAID used for castration pain mitigation in piglets (Bates et al., 2014; Baysinger et al., 2021; Bonastre et al., 2016; Burkemper…

…Meloxicam, a COX-2 specific NSAID, is the most frequently studied NSAID used for castration pain mitigation in piglets (Bates et al., 2014; Baysinger et al., 2021; Bonastre et al., 2016; Burkemper…

…Kells NJ, Beausoleil NJ, Chambers JP, Sutherland MA, Morrison RS, John‑ COX-2 inhibitor meloxicam on growing pigs. Veterinary Record. son CB. Electroencephalographic responses of anaesthetized pigs (Sus 2017;181(21):564…

…Kells NJ, Beausoleil NJ, Chambers JP, Sutherland MA, Morrison RS, John‑ COX-2 inhibitor meloxicam on growing pigs. Veterinary Record. son CB. Electroencephalographic responses of anaesthetized pigs (Sus 2017;181(21):564…

…prior to castration resulted in increased “pain-specific” behaviour in the first hours after castration as compared with sham or unhandled controls, or NSAID-treated piglets. This was predominantly due to a…

l Ltd, Hemel Hempstead, UK, 2002. reduction in total pain avoidance behaviours in the first hour, These 14, Ludbrook J. Multiple comparison procedures updated. Clin Exp Pharmacol results suggest that the NSAID had some effect in counterin Physiol 1998;25:1032-1037. g the short-term ischaemic pain induced by ring application. It is 15. Stafford KL, Mellor DJ, Todd SE, Bruce RA, Ward RN. Effects difficult of local to fully explain the marginal increase in abnormal lying postures anaesthesia or local anaesthesia plus a non-steroidal anti-inflamm atory drug on recorded in knife-castrated lambs treated with topical anaesthetic the acute cortisol response of calves to five different methods of castration, Res , Vet Sci 2002;73:61-70, One explanation could be that these animals were comfortable 16. Earley B, Crowe MA. Effects of ketoprofen alone or in combination enough to be more likely to lie down, but that once they did with local so, they anesthesia during the castration of bull calves on plasma cortisol, immuno- were still inclined to lie in a manner that avoided pressure on logical and inflammatory responses. J Anim Sci 2002;80:1044-1052, the scrotal area. 17. Thuer S, Mellema S, Doherr MG, Wechsler B, Nuss K, Steiner A. Effect of local anaesthesia on short- and long-term pain induced by two bloodless castration Where some previous research has concluded that ring castration is methods in calves. Vet/ 2007;173:333-342, more stressful to the animal than other methods, most 18. Paull DR, Lee C, Atkinson SJ, Fisher AD. The effects of meloxicam of those and conclusions were made following behavioural assessmen tolfenamic acid administration on the pain and stress responses of Merino ts with minimal physiological data to support them. Comprehensive lambs to mulesing. Aust

…prior to castration resulted in increased “pain-specific” behaviour in the first hours after castration as compared with sham or unhandled controls, or NSAID-treated piglets. This was predominantly due to a…