Food and Drug Administration

…The US Food and pain resulting from surgical castration. This methodology will Drug Administration (FDA) has oversight of approval and safety use multiple outcome variables to, in summation, demonstrate of all products…

…The US Food and pain resulting from surgical castration. This methodology will Drug Administration (FDA) has oversight of approval and safety use multiple outcome variables to, in summation, demonstrate of all products…

…Centre for Drug Evaluation and Research. Pharmacology/Toxicology Review and Evaluation: S-Caine (Lidocaine and Tetracaine) Cream 7%/7%; Federal Drug Administration: Beltsville, MD, USA; Benguet, Philippines, 2006. 58. Nordqvist, P.; Dhuner…

Posted on Authorea 16 Sep 2020 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.160029789.93744641 — This a preprint and has not been peer reviewed. Data may be preliminary. Efficacy and application of a novel topical anaesthetic wound formulation for treating cattle with Foot-and-Mouth disease: a field trial in Cameroon Sevidzem Lenze1 , Jacques Mavoungou1 , Kong Burinyuy1 , Koumba Armel1 , Simon Dickmu1 , James Young2 , Peter Thomson3 , and Peter Windsor2 1 Affiliation not available 2 University of Sydney 3 School of Life and Environmental Sciences September 16, 2020 Abstract Recently, a wound dressing formulation, (Tri-Solfen®, Medical Ethics Pty Ltd, Australia; TS) registered for use in ruminant husbandry in Australia, was registered for Foot-and-Mouth Disease (FMD) therapy in large ruminants in Laos, following clinical observations of improved welfare and healing following treatment of FMD lesions. In November 2019, an FMD outbreak in Cameroon provided an opportunity for a field trial, comparing clinical responses and recoveries to treatments on a sample of cattle (n = 36) comprising three equal groups of animals (n = 12), comparing responses to three treatments:(i) the application to lesions of TS, (ii) the administration of parenteral oxytetraycline commonly used for FMD in Cameroon; and (iii) an untreated control group (C). Appetite scores, lesion healing scores, and changes in dimensions of lesions, were recorded over a 15-day study period. Cattle treated with TS achieved both superior appetite and lesion healing scores with more rapid reduction in dimensions of lesions than other groups. Farmer observations indicated the TS treatment group had a more rapid return to eating with

tor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

tor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

…In addition, approval from the Food and Drug Administration (FDA) is required in order for producers or caretakers to administer such pain relief drugs without oversight by a veterinarian. Given these challenges…

Received: 15 September 2020 | Revised: 25 October 2020 | Accepted: 9 November 2020 DOI: 10.1111/tbed.13923 ORIGINAL ARTICLE Efficacy and application of a novel topical anaesthetic wound formulation for treating cattle with Foot-and-Mouth disease: A field trial in Cameroon Sevidzem S. Lendzele1,2 | Jacques F. Mavoungou1,3 | Kong A. Burinyuy4 | Koumba A. Armel1 | Simon J. Dickmu5 | James R. Young6 | Peter C. Thomson7 | Peter A. Windsor6 1 Institut de recherche en Ecologie Tropicale (IRET-CENAREST), Libreville, Gabon Abstract 2 Ecole Doctorale des Grandes Ecoles Recently, a wound dressing formulation, (Tri-Solfen®, Medical Ethics Pty Ltd, (EDGE), Libreville, Gabon Australia; TS) registered for use in ruminant husbandry in Australia, was registered 3 Université des Sciences et Techniques (USTM), Franceville, Gabon for Foot-and-Mouth Disease (FMD) therapy in large ruminants in Laos, following 4 School of Veterinary Science and Medicine, clinical observations of improved welfare and healing following treatment of FMD University of Ngaoundéré, Ngaoundéré, lesions. In November 2019, an FMD outbreak in Cameroon provided an opportunity Cameroon 5 for a field trial, comparing clinical responses and recoveries to treatments on a sam- The National Veterinary Laboratory (LANAVET), Garoua North, Cameroon ple of cattle (n = 36) comprising three equal groups of animals (n = 12), comparing 6 Sydney School of Veterinary Sciences, responses to three treatments: (i) the application to lesions of TS, (ii) the administra- The University of Sydney, Camden, NSW, Australia tion of parenteral oxytetraycline commonly used for FMD in Cameroon; and (iii) an 7 School of Life and Environmental Sciences, untreated control group (C). Appetite scores, lesion healing scores, and changes in The

…specific drug (30). training led by a veterinarian, following the guidelines provided The aim of the present study was to compare the effect by the Danish Veterinary and Food Administration [DVFA, of…