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Giles Innocent

10 results · hybrid · 1.202456287s

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Consultancy Deed 3%
file · #67

dential Information is disclosed warrants not to disclose the Confidential Information in accordance with clause 6.1; (b) that party obtains the prior written consent of the party who is the owner of the Confidential Information; (c) that part of the Confidential Information which is to be disclosed is available in the public domain (other than as a result of a breach by the Company of this Deed); or (d) the disclosure is required by law. 6.3 Return of Confidential Information On termination of this Deed, each party must immediately return all Confidential Information which is the property of the other party and which is in the first party's possession or control, to the party who is the owner of the Confidential Information. 6.4 Uncertainty If the Company is uncertain about whether information is Confidential Information, or lawfully within the public domain, the information is taken to be Confidential Information unless the Company is advised by the Client in writing that the information is not Confidential Information. 7 INTELLECTUAL PROPERTY AND MORAL RIGHTS 7.1 Ownership of Intellectual Property The parties acknowledge and agree that the following provisions apply in respect of ownership of Intellectual Property: (a) if the Client makes available or introduces any of the Client's Intellectual Property during the Term, then all rights to that Intellectual Property will remain the sole property of the Client; (b) if the Company makes available or introduces any of the Company's Intellectual Property during the Term, then all rights to that original Intellectual Property will remain the sole property of the Company; and 7.2 Assignment of Intellectual Property (a) The Company presently assign to the Client all existing and future Intellectual Property rights in all

Antinociceptive and wound healing effects of a commercial formulation of lidocaine, bupivacaine, adrenaline and cetrimide applied topically to superficial skin wounds in horses 2%
Shaun Pratt; Albert Sole-Guitart; Karla de Klerk; Elizabeth Evans; Jane Hume; Chiara Palmieri; Joanne Rainger; Wendy Goodwin · file · #60

…Sheil M, De Benedictis GM, Scollo A, Metcalfe S, Innocent G, 31. Gozalo-Marcilla M, Luna SP, Crosignani N, Filho JNP, Possebon Polkinghorne A, et al. Efficacy of intra-operative topical wound…

Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration 1%
Meredith Sheil and Adam Polkinghorne · file · #62

gh degree of variability in the literature of test methods employed and outcomes obtained, there is nevertheless a growing body of evidence to suggest that some piglet responses to pain induced by castration, are more consistently reproduced and specific to the pain experienced during castration than others. In this narrative review, we examine the potential indicators of pain in neonatal piglets undergoing castration to determine the optimal methods currently available to most accurately detect pain and assess pain mitigation. Abstract: Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient, and/or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review to assist in determining the optimal methods currently available to detect piglet pain during castration and methods to mitigate castration-induced pain. In overview, the optimal outcome variables identified are nociceptive motor and vocal response scores during

Optimal methods of documenting analgesic efficacy in neonatal piglets undergoing castration 1%
Meredith Sheil; Adam Polkinghorne · file · #26

he potential of misinterpreting trial outcomes. Although there is a high degree of variability in the literature of test methods employed and outcomes obtained, there is nevertheless a growing body of evidence to suggest that some piglet responses to pain induced by castration, are more consistently reproduced and specific to the pain experienced during castration than others. In this narrative review, we examine the potential indicators of pain in neonatal piglets undergoing castration to determine the optimal methods, currently available to most accurately detect pain, and assess pain mitigation. Abstract: Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient and / or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review, to assist in determining the optimal methods currently available to detect piglet pain during castration and methods to mitigate castration-induced pain. In overview, the optimal outcome

Optimal methods of documenting analgesic efficacy in neonatal piglets undergoing castration 1%
Meredith Sheil; Adam Polkinghorne · file · #93

he potential of misinterpreting trial outcomes. Although there is a high degree of variability in the literature of test methods employed and outcomes obtained, there is nevertheless a growing body of evidence to suggest that some piglet responses to pain induced by castration, are more consistently reproduced and specific to the pain experienced during castration than others. In this narrative review, we examine the potential indicators of pain in neonatal piglets undergoing castration to determine the optimal methods, currently available to most accurately detect pain, and assess pain mitigation. Abstract: Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient and / or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review, to assist in determining the optimal methods currently available to detect piglet pain during castration and methods to mitigate castration-induced pain. In overview, the optimal outcome

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