Human Wound Care

…The positive outcomes of this approach provide insights and highlight potential benefits that may be accrued from its use in human wound care, providing rapid-onset wound analgesia and/or anaesthetising wounds…

Topical Wound-care Products and Their Effects on Healing, Inflammatory Biomarkers, and Growth in Piglets Undergoing Castration Laya Kannan Silva Alves Universidade de São Paulo Monique Danielle Pairis-Garcia North Carolina State…

Topical Wound-care Products and Their Effects on Healing, Inflammatory Biomarkers, and Growth in Piglets Undergoing Castration Laya Kannan Silva Alves Universidade de São Paulo Monique Danielle Pairis-Garcia North Carolina State…

…animal wound healing in lambs undergoing mulesing. advocacy organisations. Increasingly, the infliction of pain is Design Three separate trials, placebo controlled and/or considered to breech acceptable standards of humane animal randomised…

…revolution’, with increased traction in other jurisdictions leading to studies for use in managing wounds in humans [26]. The current study involved assessment of pain-related behaviour by a numerical rating scale…

e to statistical analysis (n = 9). limb treated with LBAC and three wounds were in comparable stages of healing (Table 2). Overall, all wounds in both treatment groups exhibited heal- Mechanical threshold testing ing progression that was appropriate for the study duration and wound type. The complete histopatho- Two to three replicate MT measurements were suf- logical grade for each wound is available in the ficient to generate reproducible readings (<2 N) for supporting information. all animals. The average mechanical force required to No exuberant granulation tissue (EGT) formed elicit a behavioural response prior to wounding was within any wound treated with LBAC or saline similar between the LBAC (4.2 ± 0.6 N) and saline (4.2 (Table 3). All wounds exhibited granulation tissue ± 0.5 N) groups. The average MT measured at baseline below the skin edges on day 4. On days 11, 18 and 25, and following treatment reapplication on days 1, 2 and six LBAC-treated and six saline-treated wounds were 3 is illustrated in Figure 5. scored as grade III (Figure 4) and 16 LBAC-treated and The linear predictive model for the MT data is 14 saline-treated wounds were scored as grade II. shown in Table 1. Overall, treatment with LBAC increased the average MT required to generate a behavioural response when compared with saline (p DISCUSSION < 0.001). The most significant treatment effect was seen on day 1 (p = 0.003). On day 1, the aver- This study used MT testing to investigate the antinoci- age increase in MT following treatment with LBAC ceptive properties of a commercial formulation of was 3.0 N (minimum 1.0 N and maximum 5.0 N). LBAC applied topically to surgically created full- This effect was not influenced by time (time point thickness wounds on the distal thoracic limbs of p =

…animal experiences from a wound site in the absence of a stimulus (e.g., while lying quietly or sleeping). Kawamata et al. [71], for example, subjected human volunteers to a small incision…

…Facial expressions of emotional chronic wounds: biology, causes, and approaches to care. Adv Skin Wound Care. (2012) stress in horses. Anim Behav Cogn. (2020) 19:345231. doi: 10.1101/2020.10.19…