…eBook Collection (EBSCOhost), can be complicated by difficulties associated with iden- ERIC, E-Journals, OpenDissertations, MEDLINE, and tifying pain. The identification and grading of pain needs Global Health. Thus, studies from key…
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…eBook Collection (EBSCOhost), can be complicated by difficulties associated with iden- ERIC, E-Journals, OpenDissertations, MEDLINE, and tifying pain. The identification and grading of pain needs Global Health. Thus, studies from key…
Foundational studies in niche fields may have low citations but be the only quantitative source for a specific parameter. - Unexpected or inconvenient results. Findings that contradict your priors should increase scrutiny, not trigger automatic exclusion. - Methodological weakness on one parameter. A paper that is weak on pain duration may still provide the best available data on cortisol response. Record what the paper **can** contribute. - Manufacturer sponsorship alone. These papers are capped at Evidence Class 3, not excluded. Tag INCLUDE with a note in the NOTES column. ## Output format For each paper, produce one row of a Markdown table with these columns: - **PAPER_ID** — leave blank, researcher assigns P-001, P-002, etc. - **TITLE** — full paper title - **FIRST_AUTHOR_YEAR** — e.g. "Ranheim 2005" - **JOURNAL** — journal name - **DOI** — if available in the abstract metadata - **AI_SCREEN** — INCLUDE / EXCLUDE / UNCERTAIN - **EXCLUSION_REASON** — if EXCLUDE, one of: wrong_species / no_quant_data / conf_abstract / not_peer_reviewed / retracted / out_of_scope. If UNCERTAIN, write the specific ambiguity. If INCLUDE, leave blank. - **EVIDENCE_TYPE** — RCT / observational / review / expert — your best guess from the abstract - **PARAMETER_TYPE** — duration / intensity / prevalence / efficacy (multiple allowed) - **SPECIES_AGE_GROUP** — e.g. "neonatal piglets", "dairy calves 4–6 weeks" - **NOTES** — cross-use flags, e.g. "Also contains tail docking data — cross-tag for future SHE_TDOCK module" ## After the screening table Produce a short summary: - **Total screened:** X - **INCLUDE:** Y - **EXCLUDE:** Z (broken down by exclusion reason) - **UNCERTAIN:** W ## Verification reminder End every output with this exact line: > ⚠ AI abstract
A, Fahey T. Predicting acute finisher pigs. Livest Sci. 2018;212:45–51. 0.1016/j.livsci.2018.03.013. uncomplicated urinary tract infection in women: a systematic review of the 153. Holinger M, Früh B, Stoll P, Kreuzer M, Hilmman E, editors. Fattening pigs dis- diagnostic accuracy of symptoms and signs. BMC Fam Pract. 2010;11:78. http play weak behavioural changes due to gastric ulcerations. Book of Abstracts s://doi.org/10.1186/1471-2296-11-78. of the 71st Annual Meeting of the European Federation of Animal Science, 176. Mehta P, Leslie SW, Reddivari AKR. Dysuria. StatPearls. Treasure Island (FL): 1st-4th December, 2020, Virtuel Meeting; 2020. StatPearls Publishing Copyright © 2023. StatPearls Publishing LLC.; 2023. 154. Zalecki M. The influence of antral ulcers on intramural gastric nerve projec- 177. Farmer C, Maes D, Peltoniemi O. Mammary system. In: Zimmermann JJ, tions supplying the pyloric sphincter in the pig (Sus scrofa domestica)—neu- Karriker, LA, Ramirez, A., Schwartz, K.J., Stevenson, GW, Zhang, J, editors. In: ronal tracing studies. PLoS ONE. 2015;10(5):e0126958. https://doi.org/10.1371 Diseases of Swine, ed.11th, pp. 313–338. https://doi.org/10.1002/9781119350 /journal.pone.0126958. 927.ch18 155. Zalecki M, Juranek J, Pidsudko Z, Mogielnicka-Brzozowska M, Kaleczyc J, 178. Chou JY, Marchant JN,
A, Fahey T. Predicting acute finisher pigs. Livest Sci. 2018;212:45–51. 0.1016/j.livsci.2018.03.013. uncomplicated urinary tract infection in women: a systematic review of the 153. Holinger M, Früh B, Stoll P, Kreuzer M, Hilmman E, editors. Fattening pigs dis- diagnostic accuracy of symptoms and signs. BMC Fam Pract. 2010;11:78. http play weak behavioural changes due to gastric ulcerations. Book of Abstracts s://doi.org/10.1186/1471-2296-11-78. of the 71st Annual Meeting of the European Federation of Animal Science, 176. Mehta P, Leslie SW, Reddivari AKR. Dysuria. StatPearls. Treasure Island (FL): 1st-4th December, 2020, Virtuel Meeting; 2020. StatPearls Publishing Copyright © 2023. StatPearls Publishing LLC.; 2023. 154. Zalecki M. The influence of antral ulcers on intramural gastric nerve projec- 177. Farmer C, Maes D, Peltoniemi O. Mammary system. In: Zimmermann JJ, tions supplying the pyloric sphincter in the pig (Sus scrofa domestica)—neu- Karriker, LA, Ramirez, A., Schwartz, K.J., Stevenson, GW, Zhang, J, editors. In: ronal tracing studies. PLoS ONE. 2015;10(5):e0126958. https://doi.org/10.1371 Diseases of Swine, ed.11th, pp. 313–338. https://doi.org/10.1002/9781119350 /journal.pone.0126958. 927.ch18 155. Zalecki M, Juranek J, Pidsudko Z, Mogielnicka-Brzozowska M, Kaleczyc J, 178. Chou JY, Marchant JN,
1. Effect of treatment on total behavioral scores using UPAPS scale in castrated piglets treated with needleless lidocaine and meloxicam intramuscular (LM), needleless lidocaine and saline intramuscular (LS), needleless saline and meloxicam intramus cular (SM), needleless saline and saline intramuscular (SS) or sham castrated females (SH). Treatment p < .0001, timepoint p < .0001, treatment x timepoint p = <.0001. Pairwise comparisons between treatments with p ≤0.05 at 15 min: LM vs. LS, LM vs. SH, LS vs. SH, SM vs. SH, SS vs. SH. Discussion There continues to be a need to find both practical and effective ways of mitigating pain at the time of castration, as it is known to be a painful procedure with welfare implications for piglets (Wagner et al., 2020). The objective of this study was to determine the effect of a multimodal pain control protocol including meloxicam administered intramuscularly and lidocaine administered intrader mally on mitigating pain behaviors associated with castration. In the present study, piglets that underwent castration displayed greater total pain scores over time compared to sham castrated piglets. These results agree with decades of research that show that castration is painful (Lou et al., 2022; Schmid & Steinhoff-Wagner, 2022; M. A. Sutherland, 2015) and including a male (Garcia et al., 2023; Lopez-Soriano et al., 2022, 2023) or female (Robles et al., 2023) sham treatment group in castration studies help establish an objective baseline model for comparison. The Unesp-Botucatu Pig Composite Acute Pain Scale (UPAPS) continues to be a robust tool for pain assessment that demonstrates good intra- and inter-observer agreement, excellent predictive capabilities and responsiveness in painful and pain-free states (Robles et al., 2023).
tor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
tor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
Application of a topical anesthetic reduces pain- associated parameters during spermatic cord transection in piglet castration using a minimal anesthesia model Pauline Deffner, PhD1*; Steffanie Senf, PhD1; Anna Saller, PhD2; Julia Werner, PhD2; Judith Reiser, PhD2; Nora Abendschön, PhD1; Yury Zablotski, PhD1; Christine Baumgartner, PhD2; Mathias Ritzmann, PhD, DECPHM1; Susanne Zöls, PhD1 1Clinic for Swine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Oberschleissheim, Bavaria, Germany 2Center of Preclinical Research, Technical University of Munich, Munich, Bavaria, Germany *Corresponding author: Dr. Deffner (pauline.deffner@lmu.de) Received March 29, 2023 Accepted June 26, 2023 doi.org/10.2460/ajvr.23.03.0060 OBJECTIVE This study assessed the use of a topical anesthetic as a feasible approach to reduce pain during piglet castration using a minimal anesthesia protocol. ANIMALS 18 male piglets, aged 3–6 days, were included in this study. METHODS A minimal anesthetic state was induced with isoflurane administered by facemask, with anesthetic depth individu- ally adjusted based on responses to interdigital pinch. To desensitize the scrotal skin, a vapocoolant was applied 3 times. Scrotal incisions were made subsequently and Tri-Solfen (TS) or Placebo (P) was administered in both incisional gaps. After 30 seconds, the spermatic cords were severed followed by a further application of TS/P to both incision edges. Nociception-related variables, such as mean arterial blood pressure (MAP), heart rate (HR), and nocifensive movements, were assessed. RESULTS Significant differences in MAP changes were assessed between the TS (14 ± 4 mmHg) and the P group (36 ± 8 mmHg) for cutting the spermatic cords. Furthermore, significantly fewer
Application of a topical anesthetic reduces pain- associated parameters during spermatic cord transection in piglet castration using a minimal anesthesia model Pauline Deffner, PhD1*; Steffanie Senf, PhD1; Anna Saller, PhD2; Julia Werner, PhD2; Judith Reiser, PhD2; Nora Abendschön, PhD1; Yury Zablotski, PhD1; Christine Baumgartner, PhD2; Mathias Ritzmann, PhD, DECPHM1; Susanne Zöls, PhD1 1Clinic for Swine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Oberschleissheim, Bavaria, Germany 2Center of Preclinical Research, Technical University of Munich, Munich, Bavaria, Germany *Corresponding author: Dr. Deffner (pauline.deffner@lmu.de) Received March 29, 2023 Accepted June 26, 2023 doi.org/10.2460/ajvr.23.03.0060 OBJECTIVE This study assessed the use of a topical anesthetic as a feasible approach to reduce pain during piglet castration using a minimal anesthesia protocol. ANIMALS 18 male piglets, aged 3–6 days, were included in this study. METHODS A minimal anesthetic state was induced with isoflurane administered by facemask, with anesthetic depth individu- ally adjusted based on responses to interdigital pinch. To desensitize the scrotal skin, a vapocoolant was applied 3 times. Scrotal incisions were made subsequently and Tri-Solfen (TS) or Placebo (P) was administered in both incisional gaps. After 30 seconds, the spermatic cords were severed followed by a further application of TS/P to both incision edges. Nociception-related variables, such as mean arterial blood pressure (MAP), heart rate (HR), and nocifensive movements, were assessed. RESULTS Significant differences in MAP changes were assessed between the TS (14 ± 4 mmHg) and the P group (36 ± 8 mmHg) for cutting the spermatic cords. Furthermore, significantly fewer