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New Zealand Veterinary Journal

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Topical wound anaesthesia: efficacy to mitigate piglet castration pain 2%
ML Sheil; M Chambers; B Sharpe · file · #65

…associated with direct veterinary administration. Nonsteroidal anti-inflammatory castration (and other wounds) in lambs and calves in Australia (NSAID) medications (such as meloxicam) provide some analgesia and New Zealand. It is also…

Evaluating the efficacy of a topical anaesthetic formulation and ketoprofen, alone and in combination, on the pain sensitivity of dehorning wounds in Holstein-Friesian calves 2%
Crystal A. Espinoza; Dominique McCarthy; Peter J. White; Peter A. Windsor; Sabrina H. Lomax · file · #39

…New Zealand Veterinary Journal 44, 9–14. doi:10.1080/ anaesthetic formulation for pain management of mulesing in sheep. 00480169.1996.35924 Australian Veterinary Journal 91, 160–167. doi:10.1111/avj…

Effects of a topical anaesthetic formulation and systemic carprofen, given singly or in combination, on the cortisol and behavioural responses of Merino lambs to castration 2%
DR Pauli; C Lee; iG Colditz; AD Fisher · file · #59

PRODUCTION ANIMALS Effects of a topical anaesthetic formulation and systemic carprofen, given singly or in combination, on the cortisol and behavioural responses of Merino lambs to castration DR Pauli, C Lee, iG Colditz? and AD Fisher’* ( vee and tail docking of lambs are standard husbandry Objective To determine the effectiveness of a topical anaes- procedures in many sheep production systems. Castration thetic formulation (Tri-Solfen) with or without the administration permanently prevents the development of behavioural of a non-steroidal anti-inflammatory drug (carprofen) on the pain characteristics of male rams such as aggression towards other rams and distress response associated with ring or surgical castration of and unwanted matings, Tail docking significantly reduces the risk ram lambs, of flystrike.’ Counterbalancing the life-long outcomes of these Procedures Merino ram lambs (n = 78) were allocated to 10 husbandry practices is the associated short-term pain. Considerable treatment groups: 4 groups of knife-castrated lambs and 4 groups research has therefore examined the welfare consequences of vari- of ring-castrated lambs received carprofen (4 mg/kg SC) and ous castration and tail docking methods, and the effectiveness of Tri-Solfen; 2 control groups (sham) received carprofen at 0 or4 mg/kg analgesic strategies,” SC, Measurements included plasma cortisol and haptoglobi n Dinniss et al found that infiltrating local anaesthetic into the scrotal concentrations, haematology, and behaviour, including posture, neck was an effective method of reducing the cortisol response of Results Knife-castrated jambs had higher peak cortisol and lambs to ring castration.’ Similarly, injection of local anaesthetic into integrated cortisol responses for the first 6h

The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing 1%
DR PAULL; C LEE; IG COLDITZ; S ATKINSON; AD FISHER · file · #58

PRODUCTION ANIMALS The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing DR PAULL, C LEE, IG COLDITZ, S$] ATKINSON and AD FISHER CSIRO Livestock Industries, FD McMaster Laboratory, Armidale NSW 2350 Andrew. Fisher@csiro,au } { ulesing is a surgical procedure in which two strips of Objective To determine the pain responses of lambs to mules- skin are cut from the hindquarters of Merino lambs in ing, and the effectiveness of potential analgesic treatments. order to remove wool-bearing wrinkled skin, increase Procedures Merino lambs (n = 64) were allocated at 5 weeks the perineal bare area and reduce the risk of breech strike of age to eight treatment groups: 1) sham mules; 2) conventional throughout life thereafter. The operation is usually performed mules; 3) topical anaesthetic, incorporating lignocaine, bupi- in conjunction with tail docking during the first 12 weeks after vicaine, adrenaline and cetrimide, applied immediately after mulesing; 4) flunixin + topical anaesthetic, with flunixin admini- birth, and is described in the relevant Australian Model Code stered 2.5 mg/kg s.c. 90 min before mulesing; 5) carprofen of Practice for che Welfare of Animals.’ Although, in the years + topical anaesthetic, with carprofen administered 4 mg/kg after its widespread adoption, mulesing was highlighted for its s.c. 90 min before mulesing; 6) carprofen, administered as animal welfare benefits in reducing flystrike,” the practice has above; 7) flunixin, administered as above; and 8) carprofen more recently been the focus of criticism by animal welfare and + flunixin, administered as above. Plasma cortisol was measured animal rights interest groups, at 0, 0.5,

Impact of topical anaesthesia on pain alleviation and wound healing in lambs after mulesing 1%
S LOMAX; M SHEIL; P A WINDSOR · file · #48

en®, such as Professor Jennifer Peat PhD and funds for handling equipment the antiseptic and the gel base may be responsible for this effect, from the McGarvie Smith Institute is gratefully acknowledged. as improved healing was also documented in placebo (gel base with antiseptic) treated lambs in Trial 1. References 1. Fell LR, Shutt DA. Behavioural and hormonal responses to acute surgical The between-trial wound healing results are interesting in that stress in sheep. Appl Anim Behav Sci 1989;22:283–294. they appear to conflict with results from a previous study which 2. Grant C. Behavioural responses of lambs to common painful husbandry reported improved wound healing in younger unweaned lambs procedures. Appl Anim Behav Sci 2004;87:255–273. © 2008 The Authors Australian Veterinary Journal Volume 86, No 5, May 2008 167 Journal compilation © 2008 Australian Veterinary Association avj_285.fm Page 168 Thursday, April 17, 2008 5:08 PM PRODUCTION ANIMALS 3. Lee C, Fisher AD. The Welfare Consequences of Mulesing Sheep. Aust Vet J 24. Duarte A, Pospisilova E, Reilly E, et al. Reduction of postincisional allodynia 2007;85:89–93. by subcutaneous bupivacaine: findings with a new model in the hairy skin of the 4. Bush S. Is cocaine needed in topical anaesthesia? J Emerg Med rat. Anesthesiology 2005;103:113–125. PRODUCTION ANIMALS 2002;19:418–422. 25. Fu KY, Light AR, Maixer W. Relationship between nociceptor activity, 5. Smith GA, Strausbaugh SD, Harbeck-Weber C, et al. Comparison of topical peripheral edema, spinal microglial activation and long-term hyperalgesia anesthetics without cocaine to tetracaine-adrenaline-cocaine and lidocaine infil- induced by formalin. Neuroscience 2000;101:1127–1135. tration during repair of lacerations: bupivacaine-norepinephrine

Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration 1%
Angela Baysinger; Sherrie R. Webb; Jennifer Brown; Johann F. Coetzee; Sara Crawford; Ashley DeDecker; Locke A. Karriker; Monique Pairis-Garcia; Mhairi A. Sutherland; Abbie V. Viscardi · file · #16

…3 December 2021 50011, USA; 8North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA and 9Beef + Lamb New Zealand, 154 Featherston St., Wellington, New…

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