…a1111111111 * p.white@sydney.edu.au a1111111111 a1111111111 a1111111111 a1111111111 Abstract The aim of this study was to do determine the efficacy of the topical anaesthetic Tri-Solfen® in the amelioration of…
P. J. White
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…a1111111111 * p.white@sydney.edu.au a1111111111 a1111111111 a1111111111 a1111111111 Abstract The aim of this study was to do determine the efficacy of the topical anaesthetic Tri-Solfen® in the amelioration of…
…a1111111111 * p.white@sydney.edu.au a1111111111 a1111111111 a1111111111 a1111111111 Abstract The aim of this study was to do determine the efficacy of the topical anaesthetic Tri-Solfen® in the amelioration of…
nts were applied immediately after castration (D1). Body weights were recorded at baseline (D0) and at weaning. Blood samples were collected on days 0 (baseline), 7, and 14 for analysis of prostaglandin E₂ (PGE₂) and haptoglobin. Infrared thermography (IRT) was used to assess scrotal surface temperature. Histological evaluation of wound healing was performed on subsets of piglets on days 7 and 14. No treatment effects were observed on body weight or pre-weaning survival; castrated piglets grew similarly to intact controls. Concentrations of PGE₂ declined over time (P < 0.001) but did not differ between treatments, suggesting it may have limited utility as an inflammatory biomarker in neonatal pigs. Haptoglobin concentrations increased across all groups by days 7 and 14, including intact controls, indicating limited specificity for castration-related inflammation. In contrast, IRT consistently distinguished castrated from intact piglets, supporting its potential as a non-invasive indicator of inflammatory responses. Histological evaluations showed expected time-dependent healing progression, with epidermal thickness correlating with wound severity, but no treatment effects were found. None of the tested topical products improved wound healing or reduced systemic inflammation under a single-application protocol. While safe and without adverse effects on growth, their benefits appear limited under the study conditions. Future research should explore repeated applications, microbial wound presence, and behavioral indicators to better evaluate post-castration wound-care strategies. INTRODUCTION Castration is a common procedure performed on swine farms in the United States to prevent unwanted breeding, reduce aggression and improve meat quality (Weiler et al., 2021;
…Luna, S.P.L.; de Araujo, A.L.; da Nobrega Neto, P.I.; Brondani, J.T.; de Oliveira, F.A.; Azeredo, L.; Telles, F.G.; Trindade, P.H.E. Validation of the…
…Luna, S.P.L.; de Araujo, A.L.; da Nobrega Neto, P.I.; Brondani, J.T.; de Oliveira, F.A.; Azeredo, L.; Telles, F.G.; Trindade, P.H.E. Validation of the…
nts were applied immediately after castration (D1). Body weights were recorded at baseline (D0) and at weaning. Blood samples were collected on days 0 (baseline), 7, and 14 for analysis of prostaglandin E₂ (PGE₂) and haptoglobin. Infrared thermography (IRT) was used to assess scrotal surface temperature. Histological evaluation of wound healing was performed on subsets of piglets on days 7 and 14. No treatment effects were observed on body weight or pre-weaning survival; castrated piglets grew similarly to intact controls. Concentrations of PGE₂ declined over time (P < 0.001) but did not differ between treatments, suggesting it may have limited utility as an inflammatory biomarker in neonatal pigs. Haptoglobin concentrations increased across all groups by days 7 and 14, including intact controls, indicating limited specificity for castration-related inflammation. In contrast, IRT consistently distinguished castrated from intact piglets, supporting its potential as a non-invasive indicator of inflammatory responses. Histological evaluations showed expected time-dependent healing progression, with epidermal thickness correlating with wound severity, but no treatment effects were found. None of the tested topical products improved wound healing or reduced systemic inflammation under a single-application protocol. While safe and without adverse effects on growth, their benefits appear limited under the study conditions. Future research should explore repeated applications, microbial wound presence, and behavioral indicators to better evaluate post-castration wound-care strategies. INTRODUCTION Castration is a common procedure performed on swine farms in the United States to prevent unwanted breeding, reduce aggression and improve meat quality (Weiler et al., 2021;
Animal, page 1 of 7 © The Animal Consortium 2015 doi:10.1017/S1751731115001421 animal Effect of a topical anaesthetic formulation on the cortisol response to surgical castration of unweaned beef calves D. McCarthy†, S. Lomax, P. A. Windsor and P. J. White Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia (Received 21 October 2014; Accepted 1 July 2015) Impracticality and cost of existing pain management strategies during surgical castration of beef cattle have limited their widespread implementation on-farm. A farmer-applied topical anaesthetic formulation, originally developed and used commercially to mitigate the pain of mulesing in lambs, was investigated for its potential use for managing pain in surgically castrated calves. This formulation contained lidocaine, bupivacaine, adrenalin and cetrimide. In this study, 24 Angus bull calves were randomly allocated to (1) surgical castration (C, n = 8), (2) surgical castration with the post-operative application of topical anaesthetic (CTA, n = 8) and (3) sham castration/control (CON, n = 8). The experiment was conducted over 2 days, with treatment groups evenly represented across each day. Calves were habituated to handling before the experiment and blood samples were collected for plasma cortisol measurement at defined time periods before, at and post treatment, (at −0.5, 0 h, then +0.5, 1, 1.5, 2, 4 and 6 h). There was a significant effect of time on cortisol concentrations across all treatment groups ( P < 0.01), with lowest concentrations at −0.5 and 6 h and peak concentration at 0.5 h being significantly higher than the cortisol response at 0 h. The effect of treatment was not significant ( P = 0.077), however, there was a trend for CON calves to display lower cortisol
…Luna, S.P.L.; de Araujo, A.L.; da Nobrega Neto, P.I.; Brondani, J.T.; de Oliveira, F.A.; Azeredo, L.; Telles, F.G.; Trindade, P.H.E. Validation of the…
eting interests The authors declare no competing interests. Additional information Supplementary Information The online version contains supplementary material available at https://doi .org/1 0.10 38/s41598- 025-91551-6. Correspondence and requests for materials should be addressed to P.H.E.T. Reprints and permissions information is available at www.nature.com/reprints. Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:/ /creativec ommo ns.org /licenses/