…Multi-Centred Field Trial Meredith Sheil 1, * , Giulia Maria De Benedictis 2 , Annalisa Scollo 3 , Suzanne Metcalfe 4 , Giles Innocent 5 , Adam Polkinghorne 6,7 and Flaviana Gottardo 2 1 Animal Ethics…
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…Multi-Centred Field Trial Meredith Sheil 1, * , Giulia Maria De Benedictis 2 , Annalisa Scollo 3 , Suzanne Metcalfe 4 , Giles Innocent 5 , Adam Polkinghorne 6,7 and Flaviana Gottardo 2 1 Animal Ethics…
…Emde, R.N.; Harmon, R.J.; Metcalf, D.; Koenig, K.L.; Wagonfeld, S. Stress and neonatal sleep. Psychosom. Med. 1971, 33, 491–497, doi:10.1097/00006842-197111000-00002. 100. Gunnar, M…
…Sheil M, De Benedictis GM, Scollo A, Metcalfe S, Innocent G, 31. Gozalo-Marcilla M, Luna SP, Crosignani N, Filho JNP, Possebon Polkinghorne A, et al. Efficacy of intra-operative topical wound…
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…Emde, R.N.; Harmon, R.J.; Metcalf, D.; Koenig, K.L.; Wagonfeld, S. Stress and neonatal sleep. Psychosom Med 1971, 33, 491-497, doi:10.1097/00006842-197111000-00002. 78. Gunnar, M…
Animal (2019), 13:11, pp 2586 – 2593 © The Animal Consortium 2019 doi:10.1017/S1751731119000491 animal Behavioural measures reflect pain-mitigating effects of meloxicam in combination with Tri-Solfen® in mulesed Merino lambs L. Inglis, S. Hancock , M. Laurence and A. Thompson† School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia (Received 20 March 2018; Accepted 17 January 2019; First published online 2 April 2019) Flystrike costs the Australian industry $173 to 280 M per annum and 70% to 80% of Merino lambs are currently mulesed to reduce the risk of flystrike. To alleviate welfare concerns there has been widespread adoption of analgesics to mitigate the pain associated with mulesing. The objective of this experiment was to determine the effectiveness of Tri-Solfen® and meloxicam (Metacam® 20) at reducing pain-related behavioural responses to mulesing in Merino lambs. One hundred and forty Merino lambs were allocated to one of seven treatment groups: (1) non-mulesed (Control); (2) mulesed with no pain relief; (3) subcutaneous (s.c.) meloxicam administered 15 min before mulesing; (4) Tri-Solfen® administered at time of mulesing; (5) Tri-Solfen® and saline injection (s.c.) 15 min before mulesing; (6) Tri-Solfen® and meloxicam (s.c.) 15 min before mulesing; and (7) meloxicam (s.c.) at time the of mulesing. Behavioural responses such as standing, walking and lying were measured every 15 min for 6 h on the day of marking and for up to 2 h for 4 days thereafter. Standing (hunched v. normal) and walking (stiff v. normal) behaviours were then categorised into pain- and normal-related behaviours while lying remained in its own category. Mulesed lambs with no pain relief displayed significantly more pain-related behaviours than
Analgesia for Surgical Husbandry Procedures in Sheep and Other Livestock Dr Meredith L Sheil, Animal Ethics Pty Ltd, Associate Sydney University Faculty of Veterinary Science SUMMARY Surgical husbandry procedures in livestock are invariably associated with pain and stress, yet are traditionally performed without analgesia. Concern for the welfare of animals undergoing these procedures is contributing to major conflicts between farmers and animal advocacy organisations with important negative trade implications. Whilst the ultimate long term solution is to breed animals that do not require these procedures, or to find painless alternative practices, this will take time and a significant research effort in most cases. In the meantime, there is an urgent need to find a more immediate way to alleviate welfare concerns. This can be achieved by developing effective low-cost analgesia for on-farm use, to allow surgical procedures in livestock to be performed as humanely as surgical procedures in domestic animals and humans, while long term solutions are pursued and implemented. The first step in reaching this goal was realised with the development and commercialisation of Tri-Solfen® (Bayer Animal Health, Gordon NSW). Tri-Solfen® is a low-cost, farmer-applied topical anaesthetic, haemostatic and antiseptic wound care product that significantly alleviates pain associated with mulesing. Subsequent research identified that pre-operative administration of Carprofen enhanced the analgesic effects. Used together these agents eliminate pain-related behaviour for 24 hours post mulesing and abolish the cortisol response, thus providing highly effective analgesia that equates to (if not surpasses) that which is achieved for routine surgical procedures in veterinary clinics, such as
eting interests The authors declare no competing interests. Additional information Supplementary Information The online version contains supplementary material available at https://doi .org/1 0.10 38/s41598- 025-91551-6. Correspondence and requests for materials should be addressed to P.H.E.T. Reprints and permissions information is available at www.nature.com/reprints. Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:/ /creativec ommo ns.org /licenses/