University of Missouri

utónoma de Tabasco, Villahermosa, Martínez-Burnes J, ​Casas-Alvarado A and Mexico, 6 Department of Animal Science, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, Grandin T (2025) Clinical interpretation…

utónoma de Tabasco, Villahermosa, Martínez-Burnes J, ​Casas-Alvarado A and Mexico, 6 Department of Animal Science, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, Grandin T (2025) Clinical interpretation…

l of the product, as per label instructions. (1: immobile; 2: walking with difficulty; 3: walking normally). An ordi- Animals treated with MO received intra-muscular injections of the nal logistic mixed model was fitted to each data set with fixed effects product daily for 3 days, also at doses per label instructions (2-4 mg/kg). for Treatment, Day, Breed and Age (covariate), and a random effect for Clinical response observations were initially conducted and recorded by the individual Animal ID. A Treatment × Day interaction was included veterinary technicians with experience of observing animals with clini- in each of the models, to allow for a different shaped time course for cal FMD and these personnel trained the farmers in how to conduct the each treatment. Note that the fitted model returned a set of model- required observations. All assessors were blind to treatment to avoid based probabilities of obtaining each possible score (1 through 4, or 1 bias. The observations included the recording of any improvements in through 3), for the particular combination of terms in the model. The demeanour and interest and capacity of the animal to walk and eat, plus model was fitted using the clmm function in the ordinal package of R the following semi-quantitative clinical measurements: (Christensen, 2019), and probability estimates obtained using the em- means (Lenth, 2020) and RVAideMemoire (Hervé, 2020) packages in R. • coronary band lesion healing score (LHS) on a scale of 1 to 4 (adapted from Al-Lethie et al., 2018): • coronary band lesion size (cm): healing of coronary band lesions 2.6.2 | Binary data analysis was measured quantitatively in the field using a 30 cm ruler, every 3 days from day zero (D0) through day 15 (D15), with lesions pho- The status of cattle

al University of Life and Environmental Sciences of Ukraine (NULES), Henerala Rodimtseva 19, 03041 Kyiv, Ukraine; getya@ukr.net 8 Department of Animal Science, Faculty of Agriculture (UNIZG), University of Zagreb, Svetosimunska…

al University of Life and Environmental Sciences of Ukraine (NULES), Henerala Rodimtseva 19, 03041 Kyiv, Ukraine; getya@ukr.net 8 Department of Animal Science, Faculty of Agriculture (UNIZG), University of Zagreb, Svetosimunska…

, 45, 405–412. [CrossRef] 44. Coleman, G.; Rea, T.; Hall, M.; Sawyer, A.; Hemsworth, P.H. Multimedia training in the pig industry. Comput. Educ. 2001, 37, 257–271. [CrossRef] © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

, 45, 405–412. [CrossRef] 44. Coleman, G.; Rea, T.; Hall, M.; Sawyer, A.; Hemsworth, P.H. Multimedia training in the pig industry. Comput. Educ. 2001, 37, 257–271. [CrossRef] © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

RESEARCH ARTICLE Effect of Topically Applied Anaesthetic Formulation on the Sensitivity of Scoop Dehorning Wounds in Calves Dominique McCarthy*, Peter Andrew Windsor, Charissa Harris, Sabrina Lomax, Peter John White School of Life and Environmental Sciences, Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia * dominique.mccarthy@sydney.edu.au a11111 Abstract The post-operative effects of three formulations of topical anaesthetic and a cornual nerve block on the sensitivity of scoop dehorning wounds in calves were compared in two trials. In OPEN ACCESS Trial 1, 21 female Holstein dairy calves aged 8 to 24 weeks were randomly allocated to two Citation: McCarthy D, Windsor PA, Harris C, Lomax groups: (1) scoop dehorning with a post-operative application of a novel topical anaesthetic S, White PJ (2016) Effect of Topically Applied powder (DTAP, n = 10); and (2) scoop dehorning with a post-operative application of a Anaesthetic Formulation on the Sensitivity of Scoop novel topical anaesthetic ethanol liquid (DTAE, n = 11). In Trial 2, 18 castrated male and 18 Dehorning Wounds in Calves. PLoS ONE 11(9): female Hereford beef calves aged 16 to 20 weeks were randomly allocated to four groups: e0163181. doi:10.1371/journal.pone.0163181 (1) scoop dehorning with a pre-operative cornual nerve block of lignocaine (DCB, n = 9); (2) Editor: Francesco Staffieri, University of Bari, ITALY scoop dehorning with a post-operative application of the novel topical anaesthetic ethanol Received: June 7, 2016 liquid from Trial 1 (DTAE, n = 9); (3) scoop dehorning with a post-operative application of a Accepted: September 2, 2016 topical anaesthetic gel (DTAG, n = 9); and (4) sham dehorning (CON, n = 9). Sensitivity was Published: September 20, 2016 assessed by scoring the

ndsor, P.A., Earp, F., MacPhillamy, I., Khounsy, S., Young, J., Bush, R.D. (2020). A new topical the- rapy for Foot-and-mouth disease addresses animal welfare and other issues. Veterinary Medicine : Research Reports. in-press Table 1 . Age and breed of cattle recruited into each treatment group. Treatment group Treatment group Treatment group Variable Moore-Oxy® Tri-Solfen® Control Overall Average age (yr) 3.7 4 3.3 3.7 Age range (yr) 2 to 5 2 to 8 2 to 5 2 to 8 Breed count Goudali 9 9 10 28 Holstein 1 1 1 3 White Fulani 1 2 1 4 Red Fulani 1 0 0 1 Total 12 12 12 36 Table 2. Analysis of the number of days that cattle are immobile, number of days walking with difficulty, and number of days walking normally Walking Variable P -value Control MooreOxy® Tri-Solfen® Immobile Treatment 0.002 2.47A ± 1.39 0.05B ± 0.35 0.00B ± 0.30 Age 0.942 Breed 0.590 Sex 0.268 With Treatment 0.009 8.27A ± 4.95 3.49AB ± 2.00 0.70B ± 0.85 Difficulty Age 0.471 Breed 0.875 Sex 0.724 Normal Treatment 0.000 0.60A ± 0.40 2.72B ± 0.78 7.18C ± 1.92 Age 0.221 Breed 0.117 Sex 0.033 A B C , , : Means sharing the same superscript are not significantly different (P > 0.05). Table 3 . Analysis of the number of days that cattle are salivating. 16 Variable P -value Control MooreOxy® TriSolfen® Posted on Authorea 16 Sep 2020 — The copyright holder is the author/funder. All rights reserved. No reuse without permission. — https://doi.org/10.22541/au.160029789.93744641 — This a preprint and has not been peer reviewed. Data may be preliminary. Treatment 0.146 1.59A ± 0.82 0.49A ± 0.39 0.56A ± 0.46 Age 0.171 Breed 0.537 Sex 0.500 A : Means sharing the same superscript are not significantly different (P > 0.05). Table 4 . Analysis of the number of days that cattle are salivating. Variable P

…1Laboratory of Applied Artificial Intelligence in Health, Department of Anesthesiology, Botucatu Medical School, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil. 2Department of Veterinary Surgery and Animal Reproduction, School of Veterinary…