…The topical application of Tri-Solfen (lido- 3 Bioproperties, Glenorie, New South Wales, caine hydrochloride, bupivacaine hydrochloride, adrenaline acid tartrate and Australia cetrimide [LBAC]) produces effective postsurgical cutaneous analgesia in 4 Vetoquinol…
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…agents and adrenaline tartrate (24.8 mg/L) as a vasoconstrictor. The 3. Simpson I. Management procedures for prevention and control of flystrike. In: half-life for lidocaine in humans is reported…
change in mean arterial blood pressure (MAP) and Heart Rate (HR). Twenty minutes prior to castration, a 0.5-ml i.t. injection and a 0.5-ml subscrotal injection were administered in each testis. The six bars illustrate the maximum percent change from baseline within 1 minute after injection (A, D), skin incision (B, E) and cutting of the spermatic cord (C, F) in the different experimental groups. Handling = no injection and no castration, only simulation of the procedures; NaCl = injection of sodium chloride (NaCl) and castration; Procaine = injection of PLOS ONE | https://doi.org/10.1371/journal.pone.0236742 July 30, 2020 8 / 17 PLOS ONE Analgesic effects of local anesthesia in piglets undergoing castration procaine 4% and castration; Lidocaine = injection of lidocaine 2% and castration; Bupivacaine = injection of bupivacaine 0.5% and castration; Mepivacaine = injection of mepivacaine 2% and castration. Values shown are means ± SEMs. Statistical significance is indicated by p 0.05, p < 0.01, p < 0.001; n.s. = no significance among groups. https://doi.org/10.1371/journal.pone.0236742.g002 Catecholamines. Epinephrine and norepinephrine concentrations in piglets measured before castration as well as one minute after injection and castration are shown in Table 3. No significant differences were found among the groups at any time point. Baseline measure- ments for both epinephrine and norepinephrine greatly differed among the experimental groups. A significant increase in epinephrine from baseline to castration (H: p < 0.001, NaCl: p < 0.001, P: p < 0.001, L: p < 0.001, B: p < 0.001, M: p < 0.001) and injection to castration (H: p < 0.001, NaCl: p < 0.001, P: p < 0.001, L: p < 0.001, B: p < 0.001, M: p < 0.001) was measured within all groups. No significant differences
…Adrenalin and nor-adrenalin, produced by the adrenal medulla, positively feedback to the pituitary and increase the breakdown of proopiomelanocortins into ACTH and β-endorphins. Exogenously administered adrenalin may thus clearly impact…
…Adrenalin and nor-adrenalin, produced by the adrenal medulla, positively feedback to the pituitary and increase the breakdown of proopiomelanocortins into ACTH and β-endorphins. Exogenously administered adrenalin may thus clearly impact…
…technique 1 adrenaline Germany Mepidor® 20 mg/mL injection Mepi solution for horses; Mepivacaine 0.5 mL i.t. Two-step Two-Step Part Wirtschaftsgenossenschaft 12 hydrochloride 0.5 mL s.c…
…technique 1 adrenaline Germany Mepidor® 20 mg/mL injection Mepi solution for horses; Mepivacaine 0.5 mL i.t. Two-step Two-Step Part Wirtschaftsgenossenschaft 12 hydrochloride 0.5 mL s.c…
perimental and injection groups. groups. in the experimental Bar diagrams Bar diagrams of (A) of (A) mean mean difference difference in respiratory in respiratory rate minute rate [breaths [breaths −1minute ] between baselinebaseline −1] between and and maximum maximum respiratory respiratory rate duringrate injection, during injection, (B) mean (B)difference mean difference in meaninarterial mean blood arterialpressure blood pressure (MAP) [mmHg] (MAP) [mmHg] betweenbetween baseline baseline and maximumand maximum MAP during MAPinjection, during injection, (C) mean(C) mean difference difference in heart in heart rate [beats− minute 1 −1] between baseline and during injection, (D) mean difference in RR-Interval [ms] rate [beats minute ] between baseline and during injection, (D) mean difference in RR-Interval [ms] between baseline and during injection with the mean at the top of the bar and the whiskers as between baseline and during injection with the mean at the top of the bar and the whiskers as standard standard deviation. Boxplots of (E) difference in standard deviation of heart rate (SDHR) [beats deviation. Boxplots of (E) difference in standard deviation of heart rate (SDHR) [beats minute−1 ] minute−1] between baseline and during injection, (F) difference in standard deviation of RR-Interval between(SDRR) baseline[ms] and between during injection, baseline(F) difference and in standard during injection anddeviation of RR-Interval (G) difference in low (SDRR) frequency/high [ms] between baseline frequency andratio (LF/HF) during injection between and (G) baseline anddifference in low The during injection. frequency/high frequency boxes representing the first and (LF/HF)third ratioquartile betweenand baseline and during the whiskers injection. ranging
perimental and injection groups. groups. in the experimental Bar diagrams Bar diagrams of (A) of (A) mean mean difference difference in respiratory in respiratory rate minute rate [breaths [breaths −1minute ] between baselinebaseline −1] between and and maximum maximum respiratory respiratory rate duringrate injection, during injection, (B) mean (B)difference mean difference in meaninarterial mean blood arterialpressure blood pressure (MAP) [mmHg] (MAP) [mmHg] betweenbetween baseline baseline and maximumand maximum MAP during MAPinjection, during injection, (C) mean(C) mean difference difference in heart in heart rate [beats− minute 1 −1] between baseline and during injection, (D) mean difference in RR-Interval [ms] rate [beats minute ] between baseline and during injection, (D) mean difference in RR-Interval [ms] between baseline and during injection with the mean at the top of the bar and the whiskers as between baseline and during injection with the mean at the top of the bar and the whiskers as standard standard deviation. Boxplots of (E) difference in standard deviation of heart rate (SDHR) [beats deviation. Boxplots of (E) difference in standard deviation of heart rate (SDHR) [beats minute−1 ] minute−1] between baseline and during injection, (F) difference in standard deviation of RR-Interval between(SDRR) baseline[ms] and between during injection, baseline(F) difference and in standard during injection anddeviation of RR-Interval (G) difference in low (SDRR) frequency/high [ms] between baseline frequency andratio (LF/HF) during injection between and (G) baseline anddifference in low The during injection. frequency/high frequency boxes representing the first and (LF/HF)third ratioquartile betweenand baseline and during the whiskers injection. ranging
…g/L lignocaine hydrochloride, 4.2 g/L bupivacaine hydrochloride, 24.8 mg/L adrenaline (as acid tartrate) and 5.0 g/L cetrimide) or 2 mL of a placebo. The placebo…