aluminium chlorohydrate

…Topical Anaesthetic Formulation The TA contained two local anaesthetics, lignocaine hydrochloride (100.0 g/L) and bupivacaine hydrochloride (5.0 g/L), aluminium chlorohydrate (100.0 g/L) and cetrimide (5.0…

…This multipurpose formulation contained lignocaine and bupivacaine for local anaesthesia, cetrimide for Materials and methods antisepsis, and aluminium chlorohydrate for astringency of the Animals and housing wound. These ingredients were carried in…

or animals in Study 1. Group Animals (n) Treatment Dose level Dosing Regime 2 mL sterile saline applied on Days 0, 1 and 2 1 8 Placebo - (2 mL per day total) 2 mL Tri-Solfen® applied daily on Days 0, 1 and 2 2 8 Tri-Solfen® 1× (2 mL per day total) 2 mL Tri-Solfen® applied three times at 1 h intervals on Days 0, 1 and 2 3 8 Tri-Solfen® 3× (6 mL per day total) 2 mL Tri-Solfen® applied five times at 1 h intervals on Days 0, 1 and 2 4 8 Tri-Solfen® 5× (10 mL per day total) 2.2.1. Animal Observations Including Wound Assessment Study animals were observed for the first 30 min following each treatment and thence hourly (±15 min) for a minimum of 6 h following the final treatment of each group on each day (0, 1 and 2). Twice daily observations, undertaken by a blinded veterinarian during the morning, continued prior to euthanasia on days 3 or 4. Observations included: general behaviour and demeanour, evaluation of any appetite change, ambulation, faecal consistency and colour, skin condition, ocular and nasal discharge, and any neurologic or cardiorespiratory signs that may be indicative of an adverse drug reaction. Bodyweights of animals were measured at day −4, and prior to euthanasia. Daily feed and water intake were also assessed on an individual animal basis once daily. During each veterinary examination, disbudding wounds were examined for the pres- ence of oedema, erythema, discharge, alopecia and flaking of skin on the area surrounding the cauterised wound. In addition, all application sites were photographed on the day of necropsy. 2.2.2. Blood Sampling and Analysis Blood specimens were collected from the jugular vein of carefully restrained calves at the following time points: day −4, day 0, and prior to euthanasia. Blood samples were collected by

e to statistical analysis (n = 9). limb treated with LBAC and three wounds were in comparable stages of healing (Table 2). Overall, all wounds in both treatment groups exhibited heal- Mechanical threshold testing ing progression that was appropriate for the study duration and wound type. The complete histopatho- Two to three replicate MT measurements were suf- logical grade for each wound is available in the ficient to generate reproducible readings (<2 N) for supporting information. all animals. The average mechanical force required to No exuberant granulation tissue (EGT) formed elicit a behavioural response prior to wounding was within any wound treated with LBAC or saline similar between the LBAC (4.2 ± 0.6 N) and saline (4.2 (Table 3). All wounds exhibited granulation tissue ± 0.5 N) groups. The average MT measured at baseline below the skin edges on day 4. On days 11, 18 and 25, and following treatment reapplication on days 1, 2 and six LBAC-treated and six saline-treated wounds were 3 is illustrated in Figure 5. scored as grade III (Figure 4) and 16 LBAC-treated and The linear predictive model for the MT data is 14 saline-treated wounds were scored as grade II. shown in Table 1. Overall, treatment with LBAC increased the average MT required to generate a behavioural response when compared with saline (p DISCUSSION < 0.001). The most significant treatment effect was seen on day 1 (p = 0.003). On day 1, the aver- This study used MT testing to investigate the antinoci- age increase in MT following treatment with LBAC ceptive properties of a commercial formulation of was 3.0 N (minimum 1.0 N and maximum 5.0 N). LBAC applied topically to surgically created full- This effect was not influenced by time (time point thickness wounds on the distal thoracic limbs of p =

ricidal activity on dental alginates. Materials. 2015;8 For personal use only. (4):1966–1975. doi:10.3390/ma8041966. Veterinary Medicine: Research and Reports Dovepress Publish your work in this journal Veterinary Medicine: Research and Reports is an international, peer- and includes a very quick and fair peer-review system. Visit reviewed, open access journal publishing original research, case http://www.dovepress.com/testimonials.php to read real quotes from reports, editorials, reviews and commentaries on all areas of veterinary published authors. medicine. The manuscript management system is completely online Submit your manuscript here: http://www.dovepress.com/veterinary-medicine-research-and-reports-journal 158 DovePress Veterinary Medicine: Research and Reports 2021:12 Powered by TCPDF (www.tcpdf.org)

RESEARCH ARTICLE Effect of Topically Applied Anaesthetic Formulation on the Sensitivity of Scoop Dehorning Wounds in Calves Dominique McCarthy*, Peter Andrew Windsor, Charissa Harris, Sabrina Lomax, Peter John White School of Life and Environmental Sciences, Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia * dominique.mccarthy@sydney.edu.au a11111 Abstract The post-operative effects of three formulations of topical anaesthetic and a cornual nerve block on the sensitivity of scoop dehorning wounds in calves were compared in two trials. In OPEN ACCESS Trial 1, 21 female Holstein dairy calves aged 8 to 24 weeks were randomly allocated to two Citation: McCarthy D, Windsor PA, Harris C, Lomax groups: (1) scoop dehorning with a post-operative application of a novel topical anaesthetic S, White PJ (2016) Effect of Topically Applied powder (DTAP, n = 10); and (2) scoop dehorning with a post-operative application of a Anaesthetic Formulation on the Sensitivity of Scoop novel topical anaesthetic ethanol liquid (DTAE, n = 11). In Trial 2, 18 castrated male and 18 Dehorning Wounds in Calves. PLoS ONE 11(9): female Hereford beef calves aged 16 to 20 weeks were randomly allocated to four groups: e0163181. doi:10.1371/journal.pone.0163181 (1) scoop dehorning with a pre-operative cornual nerve block of lignocaine (DCB, n = 9); (2) Editor: Francesco Staffieri, University of Bari, ITALY scoop dehorning with a post-operative application of the novel topical anaesthetic ethanol Received: June 7, 2016 liquid from Trial 1 (DTAE, n = 9); (3) scoop dehorning with a post-operative application of a Accepted: September 2, 2016 topical anaesthetic gel (DTAG, n = 9); and (4) sham dehorning (CON, n = 9). Sensitivity was Published: September 20, 2016 assessed by scoring the

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Topical Wound-care Products and Their Effects on Healing, Inflammatory Biomarkers, and Growth in Piglets Undergoing Castration Laya Kannan Silva Alves Universidade de São Paulo Monique Danielle Pairis-Garcia North Carolina State University Juliana Bonin Ferreira North Carolina State University Victoria Rocha Merenda North Carolina State University Rubia Mitalli Tomacheski Washington State University Pedro Henrique Esteves Trindade Michigan State University Christopher Siepker Iowa State University Magdiel Lopez-Soriano University of Missouri Research Article Keywords: acute phase proteins, animal welfare, piglet mortality, thermography, weaning, wound healing Posted Date: October 12th, 2025 DOI: https://doi.org/10.21203/rs.3.rs-7722871/v1 License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Additional Declarations: No competing interests reported. Page 1/20 Abstract Surgical castration is a routine management procedure in swine production that raises welfare concerns due to pain, inflammation, and risk of post-procedure complications. Topical products are commonly applied to castration wounds, but their efficacy in promoting healing and reducing inflammation has not been systematically evaluated. This study investigated the efficacy of five commercially available topical protective products on wound healing, inflammatory responses, and growth performance in piglets undergoing surgical castration. One hundred and ninety piglets were assigned to one of six groups: Iodine, Oinkment®, PhytoCare®, Vetericyn®, Zinc Oxide, or intact controls (NoCast). Treatments were applied immediately after castration (D1). Body weights were recorded at baseline (D0) and at weaning. Blood samples were collected on days 0

Topical Wound-care Products and Their Effects on Healing, Inflammatory Biomarkers, and Growth in Piglets Undergoing Castration Laya Kannan Silva Alves Universidade de São Paulo Monique Danielle Pairis-Garcia North Carolina State University Juliana Bonin Ferreira North Carolina State University Victoria Rocha Merenda North Carolina State University Rubia Mitalli Tomacheski Washington State University Pedro Henrique Esteves Trindade Michigan State University Christopher Siepker Iowa State University Magdiel Lopez-Soriano University of Missouri Research Article Keywords: acute phase proteins, animal welfare, piglet mortality, thermography, weaning, wound healing Posted Date: October 12th, 2025 DOI: https://doi.org/10.21203/rs.3.rs-7722871/v1 License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Additional Declarations: No competing interests reported. Page 1/20 Abstract Surgical castration is a routine management procedure in swine production that raises welfare concerns due to pain, inflammation, and risk of post-procedure complications. Topical products are commonly applied to castration wounds, but their efficacy in promoting healing and reducing inflammation has not been systematically evaluated. This study investigated the efficacy of five commercially available topical protective products on wound healing, inflammatory responses, and growth performance in piglets undergoing surgical castration. One hundred and ninety piglets were assigned to one of six groups: Iodine, Oinkment®, PhytoCare®, Vetericyn®, Zinc Oxide, or intact controls (NoCast). Treatments were applied immediately after castration (D1). Body weights were recorded at baseline (D0) and at weaning. Blood samples were collected on days 0