nociceptive motor response

tilled into the wound and allowed a 30 s wait time, our group recently employed a method in which piglet castration was recorded on videotape, and the nociceptive motor response was graded…

…Reduced nociceptive motor response to the castration procedure (traction on and severing the spermatic cord) was the primary efficacy parameter for pain control dur- ing the procedure in this study. Studies of…

…Reduced nociceptive motor response to the castration procedure (traction on and severing the spermatic cord) was the primary efficacy parameter for pain control dur- ing the procedure in this study. Studies of…

…Reduced nociceptive motor response to the castration procedure (traction on and severing the spermatic cord) was the primary efficacy parameter for pain control dur- ing the procedure in this study. Studies of…

…Nociceptive motor responses during piglet castration 5 6 Piglet castration without anaesthesia induces protracted violent struggling and escape 7 behaviour in piglets during the procedure[26]. This piglet motor response is usually…

…Nociceptive motor responses during piglet castration 5 6 Piglet castration without anaesthesia induces protracted violent struggling and escape 7 behaviour in piglets during the procedure[26]. This piglet motor response is usually…

ed rank test was performed for each pixel by assessing the power of the respective frequency at the observed time versus the power of the frequency at baseline. Pixels that either had a p < 0.05 (pooled response to the interdigital pinch) or p < 0.1 (single experimental group, all other stimuli) are shown. Hence, only significant changes that occurred in clusters are discussed. The cluster approach was used because of the low probability of the concentration of spurious false positives in a cluster. Therefore, the strategy was used to define a cluster size [33], i.e., either a 4 s × 2 Hz cluster for the pooled reaction to the interdigital pinch stimulus or a 4 s × 4 Hz cluster for the reaction to other stimuli. The area under the receiver operating curve (AUC) was calculated with 10k-fold bootstrapped 95% confidence intervals to track the changes in the EEG band power over time. If the 95% confidence intervals did not cross the 0.5 line, this result was considered to be significant as long as it was observed in at least at two neighbouring time points. Similar approaches have been used previously [34,35]. MATLAB R2017a (The MathWorks, Inc., Natick, MA, United States) was used for the statistical analysis. For the AUC calculation, additional functions from the measures of the effect size toolbox were used [36]. Different settings were used for the interdigital pinch stimulus and the other noxious stimuli, as a much larger number of samples was available for the interdigital pinch by pooling data from all animals, independent of the treatment groups. Beeswarm plots were generated with the MATLAB plotSpread function. 2.3.2. FOS Protein Four tissue sections per animal were included in the analysis: one section each from spinal cord segments L1, L2, L3 and S1-3. The

…The nociceptive motor response was graded as: Statistical methods 0 = no motor response, 1 = mild motor response, such as a short- Raw data were entered into Microsoft EXCEL 2016 using double-entry…

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