Ausvet Pty Ltd.

m (Goods and Services Tax) Act 1999 and related legislation passed by the Federal Government; "Indication" means a specific animal welfare use-case or application of the Product for which an assessment is to be performed under Schedule 2; "Insolvency Administration" means any form of external administration of the property of any person whether under the provisions of the Corporations Law, the Bankruptcy Act 1966 or any other similar legislation or otherwise including bankruptcy, winding up, liquidation, voluntary administration and the appointment of a receiver or a receiver and manager; "Intellectual Property" means all forms of intellectual property rights throughout the world including copyright, registered patent, design, trademark and confidential information including know-how and trade secrets; "Manager" means the person described in Item 5 of Schedule 1; "Moral Rights" has the meaning given to it in the Copyright Amendment (Moral Rights) Act 2000 (Cth); "Product" means Tri-Solfen, a topical anaesthetic and antiseptic wound management product manufactured by the Client; "related company" has the meaning given to a related body corporate under the Corporations Act; "rights and claims" includes all rights, entitlements, claims, debts, actions, demands, suits, proceedings, liabilities, losses, sums of money, damages, expenses and costs; "Services" includes the services described in Schedule 2 and any additional or ancillary services agreed between the Company and the Client in writing from time to time; "Term" means the period from the Commencement Date until the Termination Date unless this Deed is extended by mutual agreement by the parties in writing or this Deed is otherwise terminated; and "Termination Date" means the date set out in Item 4 of Schedule 1. 1.2

…Sound files were analysed off-line by a point tip fitted (Prodigy Instruments Pty Ltd, Mount Kuring-Gai, sound consultant who was blinded to piglet treatment. For analysis, NSW, Aust), which was…

…Ward 2 1 Ausvet Pty Ltd., Bruce, ACT, Australia, 2 Faculty of Science, Sydney School of Veterinary Science, University of Sydney, Camden, NSW, Australia, 3 South East Local Land Services, Goulburn, NSW…

…Safety, Toxicology and Wound Healing Meredith Sheil 1, * , Michael Chambers 2 , Adam Polkinghorne 3,4 and Brendan Sharpe 2 1 Animal Ethics Pty. Ltd., Yarra Glen 3775, Australia 2 Invetus Pty. Ltd…

PRODUCTION ANIMALS The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing DR PAULL, C LEE, IG COLDITZ, S$] ATKINSON and AD FISHER CSIRO Livestock Industries, FD McMaster Laboratory, Armidale NSW 2350 Andrew. Fisher@csiro,au } { ulesing is a surgical procedure in which two strips of Objective To determine the pain responses of lambs to mules- skin are cut from the hindquarters of Merino lambs in ing, and the effectiveness of potential analgesic treatments. order to remove wool-bearing wrinkled skin, increase Procedures Merino lambs (n = 64) were allocated at 5 weeks the perineal bare area and reduce the risk of breech strike of age to eight treatment groups: 1) sham mules; 2) conventional throughout life thereafter. The operation is usually performed mules; 3) topical anaesthetic, incorporating lignocaine, bupi- in conjunction with tail docking during the first 12 weeks after vicaine, adrenaline and cetrimide, applied immediately after mulesing; 4) flunixin + topical anaesthetic, with flunixin admini- birth, and is described in the relevant Australian Model Code stered 2.5 mg/kg s.c. 90 min before mulesing; 5) carprofen of Practice for che Welfare of Animals.’ Although, in the years + topical anaesthetic, with carprofen administered 4 mg/kg after its widespread adoption, mulesing was highlighted for its s.c. 90 min before mulesing; 6) carprofen, administered as animal welfare benefits in reducing flystrike,” the practice has above; 7) flunixin, administered as above; and 8) carprofen more recently been the focus of criticism by animal welfare and + flunixin, administered as above. Plasma cortisol was measured animal rights interest groups, at 0, 0.5,

751-0813.2010.00551.x © 2010 The Authors 74 Australian Veterinary Journal Volume 88, No 3, March 2010 Journal compilation © 2010 Australian Veterinary Association

ensitivity of the Tri-Solfen® formulation with no active anaesthetic or testing, before being returned to their dams and turned out to vasoconstrictor ingredients. The three spray-on gels were pasture. The remaining 239 lambs were weighed, and then each provided from the manufacturer in identical 1 L containers alternate lamb was treated with Tri-Solfen®. Mulesing wounds marked only as A, B or C. After mulesing and wound photography, were photographed prior to application of Tri-Solfen in the first lambs remained in the mulesing cradle for 3 min after which 100 of these lambs. All lambs were treated with Dicyclanil then skin and wound sensitivity scoring was performed. Lambs returned to dams on pasture. Lambs and ewes were re-yarded were then moved in their treatment groups to one of four and drafted 14 and 28 days later. Wounds initially photographed © 2008 The Authors Australian Veterinary Journal Volume 86, No 5, May 2008 161 Journal compilation © 2008 Australian Veterinary Association avj_285.fm Page 162 Thursday, April 17, 2008 5:08 PM PRODUCTION ANIMALS were re-photographed and lambs were weighed then returned to pasture. PRODUCTION ANIMALS Statistical analysis Data were analysed using SPSS version 14.0® (SPSS Inc. Chicago, Illinois). Boxplots were examined and one-way analysis of variance was used to measure the short term effects of treatment groups for which there was a reasonable amount of variation. Repeated measures analysis of variance was used to examine within-subject changes over time. Breech skin sensitivity scores before mulesing were adjusted to account for the lower number of testing sites (5) when used for comparison with post mulesing scores from the direct wound assessment sites (9). The average score per site was calculated prior to

Analgesia for Surgical Husbandry Procedures in Sheep and Other Livestock Dr Meredith L Sheil, Animal Ethics Pty Ltd, Associate Sydney University Faculty of Veterinary Science SUMMARY Surgical husbandry procedures in livestock are invariably associated with pain and stress, yet are traditionally performed without analgesia. Concern for the welfare of animals undergoing these procedures is contributing to major conflicts between farmers and animal advocacy organisations with important negative trade implications. Whilst the ultimate long term solution is to breed animals that do not require these procedures, or to find painless alternative practices, this will take time and a significant research effort in most cases. In the meantime, there is an urgent need to find a more immediate way to alleviate welfare concerns. This can be achieved by developing effective low-cost analgesia for on-farm use, to allow surgical procedures in livestock to be performed as humanely as surgical procedures in domestic animals and humans, while long term solutions are pursued and implemented. The first step in reaching this goal was realised with the development and commercialisation of Tri-Solfen® (Bayer Animal Health, Gordon NSW). Tri-Solfen® is a low-cost, farmer-applied topical anaesthetic, haemostatic and antiseptic wound care product that significantly alleviates pain associated with mulesing. Subsequent research identified that pre-operative administration of Carprofen enhanced the analgesic effects. Used together these agents eliminate pain-related behaviour for 24 hours post mulesing and abolish the cortisol response, thus providing highly effective analgesia that equates to (if not surpasses) that which is achieved for routine surgical procedures in veterinary clinics, such as

…Research was sponsored by Animal Ethics Pty Ltd., and carried out by inde- pendent veterinary research company Triveritas Pty Ltd., to GCP and VICH standards, to address national and international veterinary medicines…

…Research was sponsored by Animal Ethics Pty Ltd., and carried out by inde- pendent veterinary research company Triveritas Pty Ltd., to GCP and VICH standards, to address national and international veterinary medicines…